| Phosphorothioate cap analogs stabilize mRNA and increase translational efficiency in mammalian cells E Grudzien-Nogalska, J Jemielity, J Kowalska, E Darzynkiewicz, ... Rna 13 (10), 1745-1755, 2007 | 185 | 2007 |
| Phosphorothioate cap analogs increase stability and translational efficiency of RNA vaccines in immature dendritic cells and induce superior immune responses in vivo AN Kuhn, M Diken, S Kreiter, A Selmi, J Kowalska, J Jemielity, ... Gene therapy 17 (8), 961-971, 2010 | 155 | 2010 |
| Synthesis and characterization of mRNA cap analogs containing phosphorothioate substitutions that bind tightly to eIF4E and are resistant to the decapping pyrophosphatase DcpS J Kowalska, M Lewdorowicz, J Zuberek, E Grudzien-Nogalska, ... Rna 14 (6), 1119-1131, 2008 | 93 | 2008 |
| Drosophila miR2 primarily targets the m7GpppN cap structure for translational repression A Zdanowicz, R Thermann, J Kowalska, J Jemielity, K Duncan, T Preiss, ... Molecular cell 35 (6), 881-888, 2009 | 90 | 2009 |
| Vaccine composition comprising 5′-cap modified RNA U Sahin, A Kuhn, E Darzynkiewicz, J Jemielity, J Kowalska US Patent 9,295,717, 2016 | 78 | 2016 |
| Synthetic mRNA cap analogs with a modified triphosphate bridge–synthesis, applications and prospects J Jemielity, J Kowalska, AM Rydzik, E Darzynkiewicz New Journal of Chemistry 34 (5), 829-844, 2010 | 64 | 2010 |
| Potential therapeutic applications of RNA cap analogs M Ziemniak, M Strenkowska, J Kowalska, J Jemielity Future medicinal chemistry 5 (10), 1141-1172, 2013 | 53 | 2013 |
| mRNAs containing the histone 3′ stem–loop are degraded primarily by decapping mediated by oligouridylation of the 3′ end W Su, SV Slepenkov, MK Slevin, SM Lyons, M Ziemniak, J Kowalska, ... Rna 19 (1), 1-16, 2013 | 47 | 2013 |
| Synthetic dinucleotide mRNA cap analogs with tetraphosphate 5′, 5′ bridge containing methylenebis (phosphonate) modification AM Rydzik, M Lukaszewicz, J Zuberek, J Kowalska, ZM Darzynkiewicz, ... Organic & biomolecular chemistry 7 (22), 4763-4776, 2009 | 47 | 2009 |
| A simple and rapid synthesis of nucleotide analogues containing a phosphorothioate moiety at the terminal position of the phosphate chain J Kowalska, M Lewdorowicz, E Darzynkiewicz, J Jemielity Tetrahedron letters 48 (31), 5475-5479, 2007 | 46 | 2007 |
| Preparation of synthetically challenging nucleotides using cyanoethyl P-imidazolides and microwaves M Strenkowska, P Wanat, M Ziemniak, J Jemielity, J Kowalska Organic letters 14 (18), 4782-4785, 2012 | 45 | 2012 |
| Synthesis and properties of mRNA cap analogs containing imidodiphosphate moiety—fairly mimicking natural cap structure, yet resistant to enzymatic hydrolysis AM Rydzik, M Kulis, M Lukaszewicz, J Kowalska, J Zuberek, ... Bioorganic & medicinal chemistry 20 (5), 1699-1710, 2012 | 44 | 2012 |
| Synthesis, properties, and biological activity of boranophosphate analogs of the mRNA cap: versatile tools for manipulation of therapeutically relevant cap-dependent processes J Kowalska, A Wypijewska del Nogal, ZM Darzynkiewicz, J Buck, C Nicola, ... Nucleic acids research 42 (16), 10245-10264, 2014 | 43 | 2014 |
| Synthetic mRNAs with superior translation and stability properties E Grudzien-Nogalska, J Kowalska, W Su, AN Kuhn, SV Slepenkov, ... Synthetic messenger RNA and cell metabolism modulation, 55-72, 2013 | 37 | 2013 |
| Translation, stability, and resistance to decapping of mRNAs containing caps substituted in the triphosphate chain with BH3, Se, and NH W Su, S Slepenkov, E Grudzien-Nogalska, J Kowalska, M Kulis, ... RNA 17 (5), 978-988, 2011 | 34 | 2011 |
| Virus-like particle-mediated intracellular delivery of mRNA cap analog with in vivo activity against hepatocellular carcinoma M Zochowska, AC Piguet, J Jemielity, J Kowalska, E Szolajska, JF Dufour, ... Nanomedicine: Nanotechnology, Biology and Medicine 11 (1), 67-76, 2015 | 33 | 2015 |
| Cap analogs modified with 1, 2-dithiodiphosphate moiety protect mRNA from decapping and enhance its translational potential M Strenkowska, R Grzela, M Majewski, K Wnek, J Kowalska, ... Nucleic acids research 44 (20), 9578-9590, 2016 | 32 | 2016 |
| Recognition of different nucleotidyl-derivatives as substrates of reactions catalyzed by various HIT-proteins A Guranowski, AM Wojdyła, J Zimny, A Wypijewska, J Kowalska, ... New Journal of Chemistry 34 (5), 888-893, 2010 | 30 | 2010 |
| Phosphorothioate analogs of m7GTP are enzymatically stable inhibitors of cap-dependent translation J Kowalska, M Lukaszewicz, J Zuberek, M Ziemniak, E Darzynkiewicz, ... Bioorganic & medicinal chemistry letters 19 (7), 1921-1925, 2009 | 30 | 2009 |
| Synthesis and use of anti-reverse phosphorothioate analogs of the messenger RNA cap J Jemielity, EM Grudzien-Nogalska, J Kowalska, E Darzynkiewicz, ... US Patent 8,153,773, 2012 | 29 | 2012 |
Jacek JemielityCentre of New Technologies, University of WarsawZweryfikowany adres z biogeo.uw.edu.pl
