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Daniel F Wyss
Daniel F Wyss
Structural Chemistry, Merck & Co.
Verified email at merck.com
Title
Cited by
Cited by
Year
Structural and biological characterization of pegylated recombinant interferon alpha-2b and its therapeutic implications
YS Wang, S Youngster, M Grace, J Bausch, R Bordens, DF Wyss
Advanced drug delivery reviews 54 (4), 547-570, 2002
5892002
Conformation and function of the N-linked glycan in the adhesion domain of human CD2
DF Wyss, JS Choi, J Li, MH Knoppers, KJ Willis, ARN Arulanandam, ...
Science 269 (5228), 1273-1278, 1995
4081995
An orally available non-nucleotide STING agonist with antitumor activity
BS Pan, SA Perera, JA Piesvaux, JP Presland, GK Schroeder, ...
Science 369 (6506), eaba6098, 2020
3162020
Template-assembled synthetic proteins with four-helix-bundle topology. Total chemical synthesis and conformational studies
M Mutter, GG Tuchscherer, C Miller, KH Altmann, RI Carey, DF Wyss, ...
Journal of the American Chemical Society 114 (4), 1463-1470, 1992
2571992
The structural role of sugars in glycoproteins
DF Wyss, G Wagner
Current opinion in biotechnology 7 (4), 409-416, 1996
2301996
Identification of the major positional isomer of pegylated interferon alpha-2b
YS Wang, S Youngster, J Bausch, R Zhang, C McNemar, DF Wyss
Biochemistry 39 (35), 10634-10640, 2000
1892000
Competition STD NMR for the detection of high‐affinity ligands and NMR‐based screening
YS Wang, D Liu, DF Wyss
Magnetic Resonance in Chemistry 42 (6), 485-489, 2004
1782004
Discovery of cyclic acylguanidines as highly potent and selective β-site amyloid cleaving enzyme (BACE) inhibitors: Part I Inhibitor design and validation
Z Zhu, ZY Sun, Y Ye, J Voigt, C Strickland, EM Smith, J Cumming, L Wang, ...
Journal of medicinal chemistry 53 (3), 951-965, 2010
1652010
Application of fragment-based NMR screening, X-ray crystallography, structure-based design, and focused chemical library design to identify novel μM leads for the development …
YS Wang, C Strickland, JH Voigt, ME Kennedy, BM Beyer, MM Senior, ...
Journal of medicinal chemistry 53 (3), 942-950, 2010
1552010
Structure, biology, and therapeutic implications of pegylated interferon alpha-2b
S Youngster, YS Wang, M Grace, J Bausch, R Bordens, DF Wyss
Current pharmaceutical design 8 (24), 2139-2157, 2002
1332002
The CD58 (LFA-3) binding site is a localized and highly charged surface area on the AGFCC'C" face of the human CD2 adhesion domain.
AR Arulanandam, JM Withka, DF Wyss, G Wagner, A Kister, P Pallai, ...
Proceedings of the National Academy of Sciences 90 (24), 11613-11617, 1993
1241993
The CD58 (LFA-3) binding site is a localized and highly charged surface area on the AGFCC'C" face of the human CD2 adhesion domain.
AR Arulanandam, JM Withka, DF Wyss, G Wagner, A Kister, P Pallai, ...
Proceedings of the National Academy of Sciences 90 (24), 11613-11617, 1993
1241993
Flexible lid to the p53-binding domain of human Mdm2: implications for p53 regulation
MA McCoy, JJ Gesell, MM Senior, DF Wyss
Proceedings of the National Academy of Sciences 100 (4), 1645-1648, 2003
1142003
Structure, specificity and CDR mobility of a class II restricted single-chain T-cell receptor
BJ Hare, DF Wyss, MS Osburne, PS Kern, EL Reinherz, G Wagner
Nature structural biology 6 (6), 574-581, 1999
1121999
Spatial localization of ligand binding sites from electron current density surfaces calculated from NMR chemical shift perturbations
MA McCoy, DF Wyss
Journal of the American Chemical Society 124 (39), 11758-11763, 2002
1042002
ANANTIN-A PEPTIDE ANTAGONIST OF THE ATRIAL NATRIURETIC FACTOR (ANF) II. DETERMINATION OF THE PRIMARY SEQUENCE BY NMR ON THE BASIS OF PROTON ASSIGNMENTS
DF Wyss, HW Lahm, M Manneberg, AM Labhardt
The Journal of antibiotics 44 (2), 172-180, 1991
901991
Structure of the glycosylated adhesion domain of human T lymphocyte glycoprotein CD2
JM Withka, DF Wyss, G Wagner, ARN Arulanandam, EL Reinherz, ...
Structure 1 (1), 69-81, 1993
801993
Structures of protein− protein complexes are docked using only nmr restraints from residual dipolar coupling and chemical shift perturbations
MA McCoy, DF Wyss
Journal of the American Chemical Society 124 (10), 2104-2105, 2002
782002
Combining NMR and X-ray crystallography in fragment-based drug discovery: discovery of highly potent and selective BACE-1 inhibitors
DF Wyss, YS Wang, HL Eaton, C Strickland, JH Voigt, Z Zhu, AW Stamford
Fragment-based drug discovery and X-ray crystallography, 83-114, 2012
732012
Non-peptidic small-molecule inhibitors of the single-chain hepatitis C virus NS3 protease/NS4A cofactor complex discovered by structure-based NMR screening
DF Wyss, A Arasappan, MM Senior, YS Wang, BM Beyer, FG Njoroge, ...
Journal of medicinal chemistry 47 (10), 2486-2498, 2004
712004
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