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Joshua R. Friedman
Joshua R. Friedman
Spyre Therapeutics
Zweryfikowany adres z spyre.com
Tytuł
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Cytowane przez
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Ustekinumab as induction and maintenance therapy for Crohn’s disease
BG Feagan, WJ Sandborn, C Gasink, D Jacobstein, Y Lang, JR Friedman, ...
New England journal of medicine 375 (20), 1946-1960, 2016
17542016
KAP-1, a novel corepressor for the highly conserved KRAB repression domain.
JR Friedman, WJ Fredericks, DE Jensen, DW Speicher, XP Huang, ...
Genes & development 10 (16), 2067-2078, 1996
8101996
Innate lymphoid cells promote anatomical containment of lymphoid-resident commensal bacteria
GF Sonnenberg, LA Monticelli, T Alenghat, TC Fung, NA Hutnick, ...
Science 336 (6086), 1321-1325, 2012
8052012
Krüppel-associated boxes are potent transcriptional repression domains.
JF Margolin, JR Friedman, WK Meyer, H Vissing, HJ Thiesen, ...
Proceedings of the National Academy of Sciences 91 (10), 4509-4513, 1994
7691994
The initiation of liver development is dependent on Foxa transcription factors
CS Lee, JR Friedman, JT Fulmer, KH Kaestner
Nature 435 (7044), 944-947, 2005
6772005
Targeting histone deacetylase complexes via KRAB-zinc finger proteins: the PHD and bromodomains of KAP-1 form a cooperative unit that recruits a novel isoform of the Mi-2α …
DC Schultz, JR Friedman, FJ Rauscher
Genes & development 15 (4), 428-443, 2001
6402001
Single-cell analysis of Crohn’s disease lesions identifies a pathogenic cellular module associated with resistance to anti-TNF therapy
JC Martin, C Chang, G Boschetti, R Ungaro, M Giri, JA Grout, K Gettler, ...
Cell 178 (6), 1493-1508. e20, 2019
6202019
The Foxa family of transcription factors in development and metabolism
JR Friedman, KH Kaestner
Cellular and Molecular Life Sciences CMLS 63, 2317-2328, 2006
5912006
KAP-1 corepressor protein interacts and colocalizes with heterochromatic and euchromatic HP1 proteins: a potential role for Krüppel-associated box–zinc finger proteins in …
RF Ryan, DC Schultz, K Ayyanathan, PB Singh, JR Friedman, ...
Molecular and cellular biology, 1999
4831999
MicroRNAs control intestinal epithelial differentiation, architecture, and barrier function
LB McKenna, J Schug, A Vourekas, JB McKenna, NC Bramswig, ...
Gastroenterology 139 (5), 1654-1664. e1, 2010
3702010
Epigenetic regulation of the DLK1-MEG3 microRNA cluster in human type 2 diabetic islets
V Kameswaran, NC Bramswig, LB McKenna, M Penn, J Schug, NJ Hand, ...
Cell metabolism 19 (1), 135-145, 2014
3642014
Dynamic regulation of Pdx1 enhancers by Foxa1 and Foxa2 is essential for pancreas development
N Gao, J LeLay, MZ Vatamaniuk, S Rieck, JR Friedman, KH Kaestner
Genes & development 22 (24), 3435-3448, 2008
3552008
Glucocorticoid receptor-dependent gene regulatory networks
P Phuc Le, JR Friedman, J Schug, JE Brestelli, JB Parker, IM Bochkis, ...
PLoS genetics 1 (2), e16, 2005
2902005
Liver development
Y Zong, JR Friedman
Liver disease in children, 1-813, 2014
2852014
Reconstitution of the KRAB-KAP-1 repressor complex: a model system for defining the molecular anatomy of RING-B box-coiled-coil domain-mediated protein-protein interactions
H Peng, GE Begg, DC Schultz, JR Friedman, DE Jensen, DW Speicher, ...
Journal of molecular biology 295 (5), 1139-1162, 2000
2662000
A functional genomics predictive network model identifies regulators of inflammatory bowel disease
LA Peters, J Perrigoue, A Mortha, A Iuga, W Song, EM Neiman, ...
Nature genetics 49 (10), 1437-1449, 2017
2392017
Foxa2 regulates multiple pathways of insulin secretion
KA Lantz, MZ Vatamaniuk, JE Brestelli, JR Friedman, FM Matschinsky, ...
The Journal of clinical investigation 114 (4), 512-520, 2004
2222004
Circulating microRNA is a biomarker of pediatric Crohn disease
AM Zahm, M Thayu, NJ Hand, A Horner, MB Leonard, JR Friedman
Journal of pediatric gastroenterology and nutrition 53 (1), 26-33, 2011
2072011
Hepatocyte-specific ablation of Foxa2 alters bile acid homeostasis and results in endoplasmic reticulum stress
IM Bochkis, NE Rubins, P White, EE Furth, JR Friedman, KH Kaestner
Nature medicine 14 (8), 828-836, 2008
2062008
Gut microbiota density influences host physiology and is shaped by host and microbial factors
EJ Contijoch, GJ Britton, C Yang, I Mogno, Z Li, R Ng, SR Llewellyn, ...
Elife 8, e40553, 2019
1662019
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