James Sandy
James Sandy
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Structure of arylamine N-acetyltransferase reveals a catalytic triad
JC Sinclair, J Sandy, R Delgoda, E Sim, MEM Noble
Nature structural biology 7 (7), 560-564, 2000
The structure of arylamine N-acetyltransferase from Mycobacterium smegmatis—an enzyme which inactivates the anti-tubercular drug, isoniazid
J Sandy, A Mushtaq, A Kawamura, J Sinclair, E Sim, M Noble
Journal of molecular biology 318 (4), 1071-1083, 2002
Arylamine N-acetyltransferases–of mice, men and microorganisms
A Upton, N Johnson, J Sandy, E Sim
Trends in pharmacological sciences 22 (3), 140-146, 2001
Arylamine N‐acetyltransferase of Mycobacterium tuberculosis is a polymorphic enzyme and a site of isoniazid metabolism
AM Upton, A Mushtaq, TC Victor, SL Sampson, J Sandy, DM Smith, ...
Molecular microbiology 42 (2), 309-317, 2001
Structures of lipoyl synthase reveal a compact active site for controlling sequential sulfur insertion reactions
JE Harmer, MJ Hiscox, PC Dinis, SJ Fox, A Iliopoulos, JE Hussey, ...
Biochemical Journal 464 (1), 123-133, 2014
Arylamine N-acetyltransferases: a pharmacogenomic approach to drug metabolism and endogenous function
E Sim, K Pinter, A Mushtaq, A Upton, J Sandy, S Bhakta, M Noble
Biochemical Society Transactions 31 (3), 615-619, 2003
Binding of the anti‐tubercular drug isoniazid to the arylamine N‐acetyltransferase protein from Mycobacterium smegmatis
J Sandy, S Holton, E Fullam, E Sim, M Noble
Protein Science 14 (3), 775-782, 2005
Investigation of the catalytic triad of arylamine N-acetyltransferases: essential residues required for acetyl transfer to arylamines
J Sandy, A Mushtaq, SJ Holton, P Schartau, MEM Noble, E Sim
Biochemical Journal 390 (1), 115-123, 2005
Arylamine N-acetyltransferases in mycobacteria
E Sim, J Sandy, D Evangelopoulos, E Fullam, S Bhakta, I Westwood, ...
Current drug metabolism 9 (6), 510-519, 2008
Structure of Mesorhizobium loti arylamine N-acetyltransferase 1
SJ Holton, J Dairou, J Sandy, F Rodrigues-Lima, JM Dupret, MEM Noble, ...
Acta Crystallographica Section F: Structural Biology and Crystallization …, 2005
Applications of thin-film sandwich crystallization platforms
D Axford, P Aller, J Sanchez-Weatherby, J Sandy
Acta Crystallographica Section F: Structural Biology Communications 72 (4 …, 2016
NMR investigation of the catalytic mechanism of arylamine N-acetyltransferase from Salmonella typhimurium
R Delgoda, LY Lian, J Sandy, E Sim
Biochimica et Biophysica Acta (BBA)-General Subjects 1620 (1-3), 8-14, 2003
VMXi: a fully automated, fully remote, high-flux in situ macromolecular crystallography beamline
J Sanchez-Weatherby, J Sandy, H Mikolajek, CMC Lobley, M Mazzorana, ...
Journal of synchrotron radiation 26 (1), 291-301, 2019
Mutational and expression analysis of tbnat and its response to isoniazid
C Sholto-Douglas-Vernon, J Sandy, TC Victor, E Sim, PD Helden
Journal of medical microbiology 54 (12), 1189-1197, 2005
Structural investigation of mutant Mycobacterium smegmatis arylamine N-acetyltransferase: a model for a naturally occurring functional polymorphism in Mycobacterium …
A Kawamura, J Sandy, A Upton, M Noble, E Sim
Protein expression and purification 27 (1), 75-84, 2003
Application of in situ diffraction in high-throughput structure determination platforms
P Aller, J Sanchez-Weatherby, J Foadi, G Winter, CMC Lobley, D Axford, ...
Structural Proteomics: High-Throughput Methods, 233-253, 2015
A generic protocol for protein crystal dehydration using the HC1b humidity controller
CMC Lobley, J Sandy, J Sanchez-Weatherby, M Mazzorana, T Krojer, ...
Acta Crystallographica Section D: Structural Biology 72 (5), 629-640, 2016
Novel small-molecule inhibitors of arylamine N-acetyltransferases: drug discovery by high throughput screening
I M Westwood, A Kawamura, A J Russell, J Sandy, S G Davies, E Sim
Combinatorial chemistry & high throughput screening 14 (2), 117-124, 2011
Crystal structure of the human Tip41 orthologue, TIPRL, reveals a novel fold and a binding site for the PP2Ac C-terminus
V Scorsato, TB Lima, GL Righetto, NIT Zanchin, J Brandão-Neto, J Sandy, ...
Scientific Reports 6 (1), 30813, 2016
An evaluation of adhesive sample holders for advanced crystallographic experiments
M Mazzorana, J Sanchez-Weatherby, J Sandy, CMC Lobley, T Sorensen
Acta Crystallographica Section D: Biological Crystallography 70 (9), 2390-2400, 2014
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