| Epidermal growth factor receptor: mechanisms of activation and signalling RN Jorissen, F Walker, N Pouliot, TPJ Garrett, CW Ward, AW Burgess The EGF receptor family, 33-55, 2003 | 2095 | 2003 |
| BindingDB: a web-accessible database of experimentally determined protein–ligand binding affinities T Liu, Y Lin, X Wen, RN Jorissen, MK Gilson Nucleic acids research 35 (suppl_1), D198-D201, 2007 | 1905 | 2007 |
| Crystal structure of a truncated epidermal growth factor receptor extracellular domain bound to transforming growth factor α TPJ Garrett, NM McKern, M Lou, TC Elleman, TE Adams, GO Lovrecz, ... Cell 110 (6), 763-773, 2002 | 1098 | 2002 |
| The crystal structure of a truncated ErbB2 ectodomain reveals an active conformation, poised to interact with other ErbB receptors TPJ Garrett, NM McKern, M Lou, TC Elleman, TE Adams, GO Lovrecz, ... Molecular cell 11 (2), 495-505, 2003 | 849 | 2003 |
| Metastasis-associated gene expression changes predict poor outcomes in patients with Dukes stage B and C colorectal cancer RN Jorissen, P Gibbs, M Christie, S Prakash, L Lipton, J Desai, D Kerr, ... Clinical Cancer Research 15 (24), 7642-7651, 2009 | 473 | 2009 |
| Colorectal cancer cell lines are representative models of the main molecular subtypes of primary cancer D Mouradov, C Sloggett, RN Jorissen, CG Love, S Li, AW Burgess, ... Cancer research 74 (12), 3238-3247, 2014 | 434 | 2014 |
| SMAD2, SMAD3 and SMAD4 mutations in colorectal cancer NI Fleming, RN Jorissen, D Mouradov, M Christie, A Sakthianandeswaren, ... Cancer research 73 (2), 725-735, 2013 | 375 | 2013 |
| Virtual screening of molecular databases using a support vector machine RN Jorissen, MK Gilson Journal of chemical information and modeling 45 (3), 549-561, 2005 | 343 | 2005 |
| Optimizing targeted therapeutic development: Analysis of a colorectal cancer patient population with the BRAFV600E mutation J Tie, P Gibbs, L Lipton, M Christie, RN Jorissen, AW Burgess, M Croxford, ... International journal of cancer 128 (9), 2075-2084, 2011 | 270 | 2011 |
| KRAS Mutation Is Associated with Lung Metastasis in Patients with Curatively Resected Colorectal Cancer J Tie, L Lipton, J Desai, P Gibbs, RN Jorissen, M Christie, KJ Drummond, ... Clinical Cancer Research 17 (5), 1122-1130, 2011 | 260 | 2011 |
| BRAF V600E mutant colorectal cancer subtypes based on gene expression D Barras, E Missiaglia, P Wirapati, OM Sieber, RN Jorissen, C Love, ... Clinical Cancer Research 23 (1), 104-115, 2017 | 211 | 2017 |
| Survival in stage II/III colorectal cancer is independently predicted by chromosomal and microsatellite instability, but not by specific driver mutations D Mouradov, E Domingo, P Gibbs, RN Jorissen, S Li, PY Soo, L Lipton, ... Official journal of the American College of Gastroenterology| ACG 108 (11 …, 2013 | 173 | 2013 |
| A statistical approach for detecting genomic aberrations in heterogeneous tumor samples from single nucleotide polymorphism genotyping data C Yau, D Mouradov, RN Jorissen, S Colella, G Mirza, G Steers, A Harris, ... Genome biology 11, 1-15, 2010 | 164 | 2010 |
| Different APC genotypes in proximal and distal sporadic colorectal cancers suggest distinct WNT/β-catenin signalling thresholds for tumourigenesis M Christie, RN Jorissen, D Mouradov, A Sakthianandeswaren, S Li, F Day, ... Oncogene 32 (39), 4675-4682, 2013 | 156 | 2013 |
| PIK3CA and PTEN Gene and Exon Mutation-Specific Clinicopathologic and Molecular Associations in Colorectal Cancer FL Day, RN Jorissen, L Lipton, D Mouradov, A Sakthianandeswaren, ... Clinical cancer research 19 (12), 3285-3296, 2013 | 141 | 2013 |
| The transcription cofactor c-JUN mediates phenotype switching and BRAF inhibitor resistance in melanoma R Ramsdale, RN Jorissen, FZ Li, S Al-Obaidi, T Ward, KE Sheppard, ... Science signaling 8 (390), ra82-ra82, 2015 | 135 | 2015 |
| CR1/CR2 interactions modulate the functions of the cell surface epidermal growth factor receptor F Walker, SG Orchard, RN Jorissen, NE Hall, HH Zhang, PA Hoyne, ... Journal of Biological Chemistry 279 (21), 22387-22398, 2004 | 110 | 2004 |
| Identification of a determinant of epidermal growth factor receptor ligand-binding specificity using a truncated, high-affinity form of the ectodomain TC Elleman, T Domagala, NM McKern, M Nerrie, B Lönnqvist, TE Adams, ... Biochemistry 40 (30), 8930-8939, 2001 | 109 | 2001 |
| DNA copy-number alterations underlie gene expression differences between microsatellite stable and unstable colorectal cancers RN Jorissen, L Lipton, P Gibbs, M Chapman, J Desai, IT Jones, ... Clinical cancer research 14 (24), 8061-8069, 2008 | 108 | 2008 |
| Stoichiometry, kinetic and binding analysis of the interaction between epidermal growth factor (EGF) and the extracellular domain of the EGF receptor T Domagala, N Konstantopoulos, F Smyth, RN Jorissen, L Fabri, ... Growth factors 18 (1), 11-29, 2000 | 105 | 2000 |
