Sunflower trypsin inhibitor 1 as a molecular scaffold for drug discovery A Lesner, A Legowska, M Wysocka, K Rolka Current pharmaceutical design 17 (38), 4308-4317, 2011 | 58 | 2011 |
Introduction of non-natural amino acid residues into the substrate-specific P1 position of trypsin inhibitor SFTI-1 yields potent chymotrypsin and cathepsin G inhibitors A Łęgowska, D Dębowski, A Lesner, M Wysocka, K Rolka Bioorganic & medicinal chemistry 17 (9), 3302-3307, 2009 | 54 | 2009 |
Examples of Peptide–Peptoid Hybrid Serine Protease Inhibitors Based on the Trypsin Inhibitor SFTI‐1 with Complete Protease Resistance at the P1 P1′ Reactive Site M Stawikowski, R Stawikowska, A Jaśkiewicz, E Zabłotna, K Rolka ChemBioChem 6 (6), 1057-1061, 2005 | 47 | 2005 |
Conjugates of ciprofloxacin and levofloxacin with cell-penetrating peptide exhibit antifungal activity and mammalian cytotoxicity N Ptaszyńska, K Gucwa, K Olkiewicz, M Heldt, M Serocki, A Stupak, ... International journal of molecular sciences 21 (13), 4696, 2020 | 44 | 2020 |
Inhibitors of Matriptase‐2 Based on the Trypsin Inhibitor SFTI‐1 A Gitlin, D Dębowski, N Karna, A Łęgowska, M Stirnberg, M Gütschow, ... ChemBioChem 16 (11), 1601-1607, 2015 | 40 | 2015 |
Derivatization of peptides as quaternary ammonium salts for sensitive detection by ESI‐MS M Cydzik, M Rudowska, P Stefanowicz, Z Szewczuk Journal of peptide science 17 (6), 445-453, 2011 | 38 | 2011 |
Design of serine proteinase inhibitors by combinatorial chemistry using trypsin inhibitor SFTI‐1 as a starting structure E Zabłotna, A Jaśkiewicz, A Łęgowska, H Miecznikowska, A Lesner, ... Journal of peptide science: an official publication of the European Peptide …, 2007 | 38 | 2007 |
Substrate specificity and inhibitory study of human airway trypsin-like protease M Wysocka, B Spichalska, A Lesner, M Jaros, K Brzozowski, A Łęgowska, ... Bioorganic & medicinal chemistry 18 (15), 5504-5509, 2010 | 37 | 2010 |
Design of selective substrates of proteinase 3 using combinatorial chemistry methods M Wysocka, A Lesner, K Guzow, L Mackiewicz, A Łęgowska, W Wiczk, ... Analytical biochemistry 378 (2), 208-215, 2008 | 36 | 2008 |
Trypsin inhibitors from the garden four o’clock (Mirabilis jalapa) and spinach (Spinacia oleracea) seeds: isolation, characterization and chemical synthesis J Kowalska, K Pszczoła, A Wilimowska-Pelc, I Lorenc-Kubis, E Zuziak, ... Phytochemistry 68 (11), 1487-1496, 2007 | 31 | 2007 |
Three wavelength substrate system of neutrophil serine proteinases M Wysocka, A Lesner, N Gruba, B Korkmaz, F Gauthier, M Kitamatsu, ... Analytical chemistry 84 (16), 7241-7248, 2012 | 30 | 2012 |
Application of specific cell permeable cathepsin G inhibitors resulted in reduced antigen processing in primary dendritic cells M Reich, A Lesner, A Łęgowska, M Sieńczyk, J Oleksyszyn, BO Boehm, ... Molecular immunology 46 (15), 2994-2999, 2009 | 30 | 2009 |
Vasopressin and its analogues: from natural hormones to multitasking peptides M Glavaš, A Gitlin-Domagalska, D Dębowski, N Ptaszyńska, A Łęgowska, ... International journal of molecular sciences 23 (6), 3068, 2022 | 29 | 2022 |
New potent cathepsin G phosphonate inhibitors M Sieńczyk, A Lesner, M Wysocka, A Łęgowska, E Pietrusewicz, K Rolka, ... Bioorganic & medicinal chemistry 16 (19), 8863-8867, 2008 | 28 | 2008 |
Implication of the disulfide bridge in trypsin inhibitor SFTI-1 in its interaction with serine proteinases A Łęgowska, D Dębowski, R Łukajtis, M Wysocka, C Czaplewski, ... Bioorganic & medicinal chemistry 18 (23), 8188-8193, 2010 | 27 | 2010 |
Peptomeric analogues of trypsin inhibitor SFTI-1 isolated from sunflower seeds A Łęgowska, E Bulak, M Wysocka, A Jaśkiewicz, A Lesner, D Dębowski, ... Bioorganic & medicinal chemistry 16 (10), 5644-5652, 2008 | 27 | 2008 |
Antibiotic-based conjugates containing antimicrobial HLopt2 peptide: design, synthesis, antimicrobial and cytotoxic activities N Ptaszyńska, K Gucwa, K Olkiewicz, A Łȩgowska, J Okońska, ... ACS chemical biology 14 (10), 2233-2242, 2019 | 22 | 2019 |
Inhibitory and antimicrobial activities of OGTI and HV-BBI peptides, fragments and analogs derived from amphibian skin D Dębowski, R Łukajtis, A Łęgowska, N Karna, M Pikuła, M Wysocka, ... Peptides 35 (2), 276-284, 2012 | 21 | 2012 |
Peptide conjugates of lactoferricin analogues and antimicrobials—Design, chemical synthesis, and evaluation of antimicrobial activity and mammalian cytotoxicity N Ptaszyńska, K Olkiewicz, J Okońska, K Gucwa, A Łęgowska, ... Peptides 117, 170079, 2019 | 20 | 2019 |
Relationship between copper (II) complexes with FomA adhesin fragments of F. nucleatum and colorectal cancer. Coordination pattern and ability to promote ROS production MK Lesiów, UK Komarnicka, K Stokowa-Sołtys, K Rolka, A Łęgowska, ... Dalton Transactions 47 (15), 5445-5458, 2018 | 19 | 2018 |