Philip Lowe
Philip Lowe
It's all in the dose Ltd
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In vivo regulation of interleukin 1β in patients with cryopyrin-associated periodic syndromes
HJ Lachmann, P Lowe, SD Felix, C Rordorf, K Leslie, S Madhoo, ...
Journal of Experimental Medicine 206 (5), 1029-1036, 2009
Calcitonin and insulin in isobutylcyanoacrylate nanocapsules: protection against proteases and effect on intestinal absorption in rats
Journal of pharmacy and pharmacology 46 (7), 547-552, 1994
Omalizumab in asthma: an update on recent developments
M Humbert, W Busse, NA Hanania, PJ Lowe, J Canvin, VJ Erpenbeck, ...
The Journal of Allergy and Clinical Immunology: In Practice 2 (5), 525-536. e1, 2014
Pharmacokinetics, pharmacodynamics and safety of QGE031 (ligelizumab), a novel high‐affinity anti‐IgE antibody, in atopic subjects
JP Arm, I Bottoli, A Skerjanec, D Floch, A Groenewegen, S Maahs, ...
Clinical & Experimental Allergy 44 (11), 1371-1385, 2014
A mechanism‐based binding model for the population pharmacokinetics and pharmacodynamics of omalizumab
N Hayashi, Y Tsukamoto, WM Sallas, PJ Lowe
British journal of clinical pharmacology 63 (5), 548-561, 2007
Pharmacokinetic and Pharmacodynamic Properties of Canakinumab, a Human Anti-Interleukin-1 Monoclonal Antibody
A Chakraborty, S Tannenbaum, C Rordorf, PJ Lowe, D Floch, H Gram, ...
Clinical Pharmacokinetics 51 (6), e1-e18, 2012
Relationship between omalizumab pharmacokinetics, IgE pharmacodynamics and symptoms in patients with severe persistent allergic (IgE‐mediated) asthma
PJ Lowe, S Tannenbaum, A Gautier, P Jimenez
British journal of clinical pharmacology 68 (1), 61-76, 2009
Asthma symptom re-emergence after omalizumab withdrawal correlates well with increasing IgE and decreasing pharmacokinetic concentrations
RG Slavin, C Ferioli, SJ Tannenbaum, C Martin, M Blogg, PJ Lowe
Journal of Allergy and Clinical Immunology 123 (1), 107-113. e3, 2009
Omalizumab decreases IgE production in patients with allergic (IgE‐mediated) asthma; PKPD analysis of a biomarker, total IgE
PJ Lowe, D Renard
British journal of clinical pharmacology 72 (2), 306-320, 2011
Physiologically based pharmacokinetic modeling of FTY720 (2-amino-2 [2-(-4-octylphenyl) ethyl] propane-1, 3-diol hydrochloride) in rats after oral and intravenous doses
GML Meno-Tetang, H Li, S Mis, N Pyszczynski, P Heining, P Lowe, ...
Drug metabolism and disposition 34 (9), 1480-1487, 2006
Hormonal regulation of hepatocyte tight junctional permeability
PJ Lowe, K Miyai, JH Steinbach, WGM Hardison
Am J Physiol 255 (4 Pt 1), G454-G461, 1988
Membrane lipid composition and susceptibility to bile salt damage
R Coleman, PJ Lowe, D Billington
Biochimica et Biophysica Acta (BBA)-Biomembranes 599 (1), 294-300, 1980
Efficacy and safety of multiple doses of QGE031 (ligelizumab) versus omalizumab and placebo in inhibiting allergen-induced early asthmatic responses
GM Gauvreau, JP Arm, LP Boulet, R Leigh, DW Cockcroft, BE Davis, ...
Journal of Allergy and Clinical Immunology 138 (4), 1051-1059, 2016
The effects of colchicine on secretion into bile of bile salts, phospholipids, cholesterol and plasma membrane enzymes: bile salts are secreted unaccompanied by phospholipids …
SG Barnwell, PJ Lowe, R Coleman
Biochemical Journal 220 (3), 723-731, 1984
On the prediction of the human response: a recycled mechanistic pharmacokinetic/pharmacodynamic approach
GML Meno‐Tetang, PJ Lowe
Basic & clinical pharmacology & toxicology 96 (3), 182-192, 2005
Transcytosis and paracellular movements of horseradish peroxidase across liver parenchymal tissue from blood to bile. Effects of alpha-naphthylisothiocyanate and colchicine
PJ Lowe, KS Kan, SG Barnwell, RK Sharma, R Coleman
Biochemical Journal 229 (2), 529-537, 1985
Rapid kinetic analysis of the bile-salt-dependent secretion of phospholipid, cholesterol and a plasma-membrane enzyme into bile
PJ Lowe, SG Barnwell, R Coleman
Biochemical Journal 222 (3), 631-637, 1984
On the anticipation of the human dose in first-in-man trials from preclinical and prior clinical information in early drug development
PJ Lowe, Y Hijazi, O Luttringer, H Yin, R Sarangapani, D Howard
Xenobiotica 37 (10-11), 1331-1354, 2007
Effect of taurochenodeoxycholate or tauroursodeoxycholate upon biliary output of phospholipids and plasma-membrane enzymes, and the extent of cell damage, in isolated perfused …
SG Barnwell, PJ Lowe, R Coleman
Biochemical Journal 216 (1), 107-111, 1983
Membrane fluidity and bile salt damage
PJ Lowe, R Coleman
Biochimica et Biophysica Acta (BBA)-Biomembranes 640 (1), 55-65, 1981
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