Daniel Wacker
Daniel Wacker
Assistant Professor, Icahn School of Medicine at Mount Sinai, New York
Verified email at - Homepage
Cited by
Cited by
Structure of the human κ-opioid receptor in complex with JDTic
H Wu, D Wacker, M Mileni, V Katritch, GW Han, E Vardy, W Liu, ...
Nature 485 (7398), 327-332, 2012
Structural features for functional selectivity at serotonin receptors
D Wacker, C Wang, V Katritch, GW Han, XP Huang, E Vardy, JD McCorvy, ...
Science 340 (6132), 615-619, 2013
Lipidic cubic phase injector facilitates membrane protein serial femtosecond crystallography
U Weierstall, D James, C Wang, TA White, D Wang, W Liu, JCH Spence, ...
Nature communications 5 (1), 3309, 2014
Structural basis for molecular recognition at serotonin receptors
C Wang, Y Jiang, J Ma, H Wu, D Wacker, V Katritch, GW Han, W Liu, ...
Science 340 (6132), 610-614, 2013
Serial femtosecond crystallography of G protein–coupled receptors
W Liu, D Wacker, C Gati, GW Han, D James, D Wang, G Nelson, ...
Science 342 (6165), 1521-1524, 2013
How ligands illuminate GPCR molecular pharmacology
D Wacker, RC Stevens, BL Roth
Cell 170 (3), 414-427, 2017
Structure of the human glucagon class B G-protein-coupled receptor
FY Siu, M He, C De Graaf, GW Han, D Yang, Z Zhang, C Zhou, Q Xu, ...
Nature 499 (7459), 444-449, 2013
Crystal structure of an LSD-bound human serotonin receptor
D Wacker, S Wang, JD McCorvy, RM Betz, AJ Venkatakrishnan, A Levit, ...
Cell 168 (3), 377-389. e12, 2017
Conserved Binding Mode of Human β2 Adrenergic Receptor Inverse Agonists and Antagonist Revealed by X-ray Crystallography
D Wacker, G Fenalti, MA Brown, V Katritch, R Abagyan, V Cherezov, ...
Journal of the American Chemical Society 132 (33), 11443-11445, 2010
Structure of the D2 dopamine receptor bound to the atypical antipsychotic drug risperidone
S Wang, T Che, A Levit, BK Shoichet, D Wacker, BL Roth
Nature 555 (7695), 269-273, 2018
Structure of the nanobody-stabilized active state of the kappa opioid receptor
T Che, S Majumdar, SA Zaidi, P Ondachi, JD McCorvy, S Wang, ...
Cell 172 (1), 55-67. e15, 2018
Structure of a hallucinogen-activated Gq-coupled 5-HT2A serotonin receptor
K Kim, T Che, O Panova, JF DiBerto, J Lyu, BE Krumm, D Wacker, ...
Cell 182 (6), 1574-1588. e19, 2020
5-HT2C receptor structures reveal the structural basis of GPCR polypharmacology
Y Peng, JD McCorvy, K Harpsøe, K Lansu, S Yuan, P Popov, L Qu, M Pu, ...
Cell 172 (4), 719-730. e14, 2018
D4 dopamine receptor high-resolution structures enable the discovery of selective agonists
S Wang, D Wacker, A Levit, T Che, RM Betz, JD McCorvy, ...
Science 358 (6361), 381-386, 2017
Structural determinants of 5-HT2B receptor activation and biased agonism
JD McCorvy, D Wacker, S Wang, B Agegnehu, J Liu, K Lansu, AR Tribo, ...
Nature structural & molecular biology 25 (9), 787-796, 2018
Artificial intelligence and machine learning‐aided drug discovery in central nervous system diseases: State‐of‐the‐arts and future directions
S Vatansever, A Schlessinger, D Wacker, HÜ Kaniskan, J Jin, MM Zhou, ...
Medicinal research reviews 41 (3), 1427-1473, 2021
GPCR stabilization using the bicelle-like architecture of mixed sterol-detergent micelles
AA Thompson, JJ Liu, E Chun, D Wacker, H Wu, V Cherezov, RC Stevens
Methods 55 (4), 310-317, 2011
Nanobody-enabled monitoring of kappa opioid receptor states
T Che, J English, BE Krumm, K Kim, E Pardon, RHJ Olsen, S Wang, ...
Nature communications 11 (1), 1145, 2020
Agonists for 13 trace amine-associated receptors provide insight into the molecular basis of odor selectivity
DM Ferrero, D Wacker, MA Roque, MW Baldwin, RC Stevens, SD Liberles
ACS Chemical Biology 7 (7), 1184-1189, 2012
Structural and functional analysis of Nup120 suggests ring formation of the Nup84 complex
HS Seo, Y Ma, EW Debler, D Wacker, S Kutik, G Blobel, A Hoelz
Proceedings of the National Academy of Sciences 106 (34), 14281-14286, 2009
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