| Small-molecule inhibition of the interaction between the translation initiation factors eIF4E and eIF4G NJ Moerke, H Aktas, H Chen, S Cantel, MY Reibarkh, A Fahmy, JD Gross, ... Cell 128 (2), 257-267, 2007 | 629 | 2007 |
| Ras links growth factor signaling to the cell cycle machinery via regulation of cyclin D1 and the Cdk inhibitor p27KIP1 H Aktas, H Cai, GM Cooper Molecular and cellular biology, 1997 | 600 | 1997 |
| Anticancer effects of thiazolidinediones are independent of peroxisome proliferator-activated receptor γ and mediated by inhibition of translation initiation SS Palakurthi, H Aktas, LM Grubissich, RM Mortensen, JA Halperin Cancer research 61 (16), 6213-6218, 2001 | 421 | 2001 |
| Novel arylsulfoanilide− oxindole hybrid as an anticancer agent that inhibits translation initiation A Natarajan, Y Guo, F Harbinski, YH Fan, H Chen, L Luus, J Diercks, ... Journal of medicinal chemistry 47 (21), 4979-4982, 2004 | 189 | 2004 |
| Depletion of intracellular Ca2+ stores, phosphorylation of eIF2α, and sustained inhibition of translation initiation mediate the anticancer effects of clotrimazole H Aktas, R Flückiger, JA Acosta, JM Savage, SS Palakurthi, JA Halperin Proceedings of the National Academy of Sciences 95 (14), 8280-8285, 1998 | 165 | 1998 |
| Ultrahigh-Resolution 1H−13C HSQC Spectra of Metabolite Mixtures Using Nonlinear Sampling and Forward Maximum Entropy Reconstruction SG Hyberts, GJ Heffron, NG Tarragona, K Solanky, KA Edmonds, ... Journal of the American Chemical Society 129 (16), 5108-5116, 2007 | 158 | 2007 |
| Inhibition of translation initiation mediates the anticancer effect of the n-3 polyunsaturated fatty acid eicosapentaenoic acid SS Palakurthi, R Flückiger, H Aktas, AK Changolkar, A Shahsafaei, ... Cancer research 60 (11), 2919-2925, 2000 | 158 | 2000 |
| Chemical genetics identify eIF2α kinase heme-regulated inhibitor as an anticancer target T Chen, D Ozel, Y Qiao, F Harbinski, L Chen, S Denoyelle, X He, ... Nature chemical biology 7 (9), 610-616, 2011 | 135 | 2011 |
| SARS-CoV-2 Infects Endothelial Cells In Vivo and In Vitro F Liu, K Han, R Blair, K Kenst, Z Qin, B Upcin, P Wörsdörfer, CC Midkiff, ... Frontiers in cellular and infection microbiology 11, 701278, 2021 | 132 | 2021 |
| Nutritional oncology D Heber Elsevier, 2011 | 123 | 2011 |
| 3, 3-Diaryl-1, 3-dihydroindol-2-ones as antiproliferatives mediated by translation initiation inhibition A Natarajan, YH Fan, H Chen, Y Guo, J Iyasere, F Harbinski, WJ Christ, ... Journal of medicinal chemistry 47 (8), 1882-1885, 2004 | 120 | 2004 |
| Tumor suppression by small molecule inhibitors of translation initiation L Chen, BH Aktas, Y Wang, X He, R Sahoo, N Zhang, S Denoyelle, ... Oncotarget 3 (8), 869, 2012 | 112 | 2012 |
| Human CD59 inhibitor sensitizes rituximab-resistant lymphoma cells to complement-mediated cytolysis W Hu, X Ge, T You, T Xu, J Zhang, G Wu, Z Peng, M Chorev, BH Aktas, ... Cancer research 71 (6), 2298-2307, 2011 | 106 | 2011 |
| Structure of the eukaryotic translation initiation factor eIF4E in complex with 4EGI-1 reveals an allosteric mechanism for dissociating eIF4G E Papadopoulos, S Jenni, E Kabha, KJ Takrouri, T Yi, N Salvi, RE Luna, ... Proceedings of the National Academy of Sciences 111 (31), E3187-E3195, 2014 | 92 | 2014 |
| Deficiency of the mouse complement regulatory protein mCd59b results in spontaneous hemolytic anemia with platelet activation and progressive male infertility X Qin, N Krumrei, L Grubissich, M Dobarro, H Aktas, G Perez, JA Halperin Immunity 18 (2), 217-227, 2003 | 90 | 2003 |
| Maintenance of bovine oocytes in prophase of meiosis I by high [cAMP] i H Aktas, MB Wheeler, CF Rosenkrans, NL First, ML Leibfried-Rutledge Reproduction 105 (2), 227-235, 1995 | 90 | 1995 |
| Endothelial cell infection and dysfunction, immune activation in severe COVID-19 Z Qin, F Liu, R Blair, C Wang, H Yang, J Mudd, JM Currey, N Iwanaga, ... Theranostics 11 (16), 8076, 2021 | 87 | 2021 |
| Maintenance of meiotic arrest by increasing [cAMP] i may have physiological relevance in bovine oocytes H Aktas, MB Wheeler, NL First, ML Leibfried-Rutledge Reproduction 105 (2), 237-245, 1995 | 86 | 1995 |
| Distinct fate, dynamics and niches of renal macrophages of bone marrow or embryonic origins F Liu, S Dai, D Feng, Z Qin, X Peng, SSVP Sakamuri, M Ren, L Huang, ... Nature communications 11 (1), 2280, 2020 | 70 | 2020 |
| Synthesis and biological evaluation of thiazolidine-2, 4-dione and 2, 4-thione derivatives as inhibitors of translation initiation H Chen, YH Fan, A Natarajan, Y Guo, J Iyasere, F Harbinski, L Luus, ... Bioorganic & medicinal chemistry letters 14 (21), 5401-5405, 2004 | 68 | 2004 |
Gerhard WagnerHarvard Medical SchoolVerified email at hms.harvard.edu
