Ian Hickson
Ian Hickson
CRUK Newcastle Drug Discovery Unit, Newcastle University
Verified email at - Homepage
Cited by
Cited by
Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy
H Farmer, N McCabe, CJ Lord, ANJ Tutt, DA Johnson, TB Richardson, ...
Nature 434 (7035), 917-921, 2005
Identification and characterization of a novel and specific inhibitor of the ataxia-telangiectasia mutated kinase ATM
I Hickson, Y Zhao, CJ Richardson, SJ Green, NMB Martin, AI Orr, ...
Cancer research 64 (24), 9152-9159, 2004
AZD8055 is a potent, selective, and orally bioavailable ATP-competitive mammalian target of rapamycin kinase inhibitor with in vitro and in vivo antitumor activity
CM Chresta, BR Davies, I Hickson, T Harding, S Cosulich, SE Critchlow, ...
Cancer research 70 (1), 288-298, 2010
Discovery of 4-{4-[(3R)-3-Methylmorpholin-4-yl]-6-[1-(methylsulfonyl)cyclopropyl]pyrimidin-2-yl}-1H-indole (AZ20): A Potent and Selective Inhibitor of ATR Protein …
KM Foote, K Blades, A Cronin, S Fillery, SS Guichard, L Hassall, I Hickson, ...
Journal of medicinal chemistry 56 (5), 2125-2138, 2013
JNJ-26481585, a novel second-generation oral histone deacetylase inhibitor, shows broad-spectrum preclinical antitumoral activity
J Arts, P King, A Marin, W Floren, A Belin, L Janssen, I Pilatte, B Roux, ...
Clinical Cancer Research 15 (22), 6841-6851, 2009
Pyranone, thiopyranone, and pyridone inhibitors of phosphatidylinositol 3-kinase related kinases. Structure− activity relationships for DNA-dependent protein kinase inhibition …
JJ Hollick, LJM Rigoreau, C Cano-Soumillac, X Cockcroft, NJ Curtin, ...
Journal of medicinal chemistry 50 (8), 1958-1972, 2007
The discovery and optimisation of pyrido [2, 3-d] pyrimidine-2, 4-diamines as potent and selective inhibitors of mTOR kinase
K Malagu, H Duggan, K Menear, M Hummersone, S Gomez, C Bailey, ...
Bioorganic & medicinal chemistry letters 19 (20), 5950-5953, 2009
O 6-Benzylguanine Potentiates the In Vivo Toxicity and Clastogenicity of Temozolomide and BCNU in Mouse Bone Marrow
N Chinnasamy, JA Rafferty, I Hickson, J Ashby, H Tinwell, GP Margison, ...
Blood, The Journal of the American Society of Hematology 89 (5), 1566-1573, 1997
Identification and optimisation of novel and selective small molecular weight kinase inhibitors of mTOR
KA Menear, S Gomez, K Malagu, C Bailey, K Blackburn, XL Cockcroft, ...
Bioorganic & Medicinal Chemistry Letters 19 (20), 5898-5901, 2009
Chemoprotective gene transfer II: multilineage in vivo protection of haemopoiesis against the effects of an antitumour agent by expression of a mutant human O6-alkylguanine-DNA …
N Chinnasamy, JA Rafferty, I Hickson, LS Lashford, SJ Longhurst, ...
Gene therapy 5 (6), 842-847, 1998
Chemoprotection of normal tissues by transfer of drug resistance genes
JA Rafferty, I Hickson, N Chinnasamy, LS Lashford, GP Margison, ...
Cancer and Metastasis Reviews 15, 365-383, 1996
USP 45 deubiquitylase controls ERCC 1–XPF endonuclease‐mediated DNA damage responses
AB Perez‐Oliva, C Lachaud, P Szyniarowski, I Muñoz, T Macartney, ...
The EMBO journal 34 (3), 326-343, 2015
Initial testing (stage 1) of the histone deacetylase inhibitor, quisinostat (JNJ‐26481585), by the Pediatric Preclinical Testing Program
H Carol, R Gorlick, EA Kolb, CL Morton, DM Manesh, ST Keir, ...
Pediatric blood & cancer 61 (2), 245-252, 2014
The fluorescent two-hybrid assay to screen for protein–protein interaction inhibitors in live cells: targeting the interaction of p53 with Mdm2 and Mdm4
L Yurlova, M Derks, A Buchfellner, I Hickson, M Janssen, D Morrison, ...
Journal of biomolecular screening 19 (4), 516-525, 2014
Chemoprotective gene transfer I: transduction of human haemopoietic progenitors with O6-benzylguanine-resistant O6-alkylguanine-DNA alkyltransferase attenuates the toxic …
I Hickson, LJ Fairbairn, N Chinnasamy, LS Lashford, N Thatcher, ...
Gene Therapy 5 (6), 835-841, 1998
Modulating androgen receptor-driven transcription in prostate cancer with selective CDK9 inhibitors
A Richters, SK Doyle, DB Freeman, C Lee, BS Leifer, S Jagannathan, ...
Cell Chemical Biology 28 (2), 134-147. e14, 2021
Protection of mammalian cells against chloroethylating agent toxicity by an O6-benzylguanine-resistant mutant of human O6-alkylguanine-DNA alkyltransferase.
I Hickson, LJ Fairbairn, N Chinnasamy, TM Dexter, GP Margison, ...
Gene therapy 3 (10), 868-877, 1996
Ubiquitinated aldolase B accumulates during starvation‐induced lysosomal proteolysis
SE Lenk, PP Susan, I Hickson, T Jasionowski, WA Dunn Jr
Journal of cellular physiology 178 (1), 17-27, 1999
FEN1 blockade for platinum chemo-sensitization and synthetic lethality in epithelial ovarian cancers
KA Mesquita, R Ali, R Doherty, MS Toss, I Miligy, A Alblihy, D Dorjsuren, ...
Cancers 13 (8), 1866, 2021
Discovery of JNJ-63576253: a clinical stage androgen receptor antagonist for F877L mutant and wild-type castration-resistant prostate cancer (mCRPC)
Z Zhang, PJ Connolly, HK Lim, V Pande, L Meerpoel, C Teleha, ...
Journal of Medicinal Chemistry 64 (2), 909-924, 2021
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