A mutation in APP protects against Alzheimer’s disease and age-related cognitive decline T Jonsson, JK Atwal, S Steinberg, J Snaedal, PV Jonsson, S Bjornsson, ... Nature 488 (7409), 96-99, 2012 | 2101 | 2012 |
Inhibition of Dll4 signalling inhibits tumour growth by deregulating angiogenesis J Ridgway, G Zhang, Y Wu, S Stawicki, WC Liang, Y Chanthery, ... Nature 444 (7122), 1083-1087, 2006 | 1190 | 2006 |
Therapeutic antibody targeting of individual Notch receptors Y Wu, C Cain-Hom, L Choy, TJ Hagenbeek, GP De Leon, Y Chen, ... Nature 464 (7291), 1052-1057, 2010 | 846 | 2010 |
Boosting brain uptake of a therapeutic antibody by reducing its affinity for a transcytosis target YJ Yu, Y Zhang, M Kenrick, K Hoyte, W Luk, Y Lu, J Atwal, JM Elliott, ... Science translational medicine 3 (84), 84ra44-84ra44, 2011 | 791 | 2011 |
Blocking neuropilin-1 function has an additive effect with anti-VEGF to inhibit tumor growth Q Pan, Y Chanthery, WC Liang, S Stawicki, J Mak, N Rathore, RK Tong, ... Cancer cell 11 (1), 53-67, 2007 | 673 | 2007 |
Engaging neuroscience to advance translational research in brain barrier biology EA Neuwelt, B Bauer, C Fahlke, G Fricker, C Iadecola, D Janigro, ... Nature Reviews Neuroscience 12 (3), 169-182, 2011 | 640 | 2011 |
The Drosophila cell corpse engulfment receptor Draper mediates glial clearance of severed axons JM MacDonald, MG Beach, E Porpiglia, AE Sheehan, RJ Watts, ... Neuron 50 (6), 869-881, 2006 | 531 | 2006 |
TREM2 regulates microglial cholesterol metabolism upon chronic phagocytic challenge AA Nugent, K Lin, B Van Lengerich, S Lianoglou, L Przybyla, SS Davis, ... Neuron 105 (5), 837-854. e9, 2020 | 431 | 2020 |
Axon pruning during Drosophila metamorphosis: evidence for local degeneration and requirement of the ubiquitin-proteasome system RJ Watts, ED Hoopfer, L Luo Neuron 38 (6), 871-885, 2003 | 429 | 2003 |
Blocking neuropilin-2 function inhibits tumor cell metastasis M Caunt, J Mak, WC Liang, S Stawicki, Q Pan, RK Tong, J Kowalski, C Ho, ... Cancer cell 13 (4), 331-342, 2008 | 418 | 2008 |
Involvement of the ubiquitin-proteasome system in the early stages of wallerian degeneration Q Zhai, J Wang, A Kim, Q Liu, R Watts, E Hoopfer, T Mitchison, L Luo, ... Neuron 39 (2), 217-225, 2003 | 381 | 2003 |
An effector-reduced anti-β-amyloid (Aβ) antibody with unique aβ binding properties promotes neuroprotection and glial engulfment of Aβ O Adolfsson, M Pihlgren, N Toni, Y Varisco, AL Buccarello, K Antoniello, ... Journal of Neuroscience 32 (28), 9677-9689, 2012 | 370 | 2012 |
Therapeutic bispecific antibodies cross the blood-brain barrier in nonhuman primates YJ Yu, JK Atwal, Y Zhang, RK Tong, KR Wildsmith, C Tan, N Bien-Ly, ... Science translational medicine 6 (261), 261ra154-261ra154, 2014 | 365 | 2014 |
VEGF-B is dispensable for blood vessel growth but critical for their survival, and VEGF-B targeting inhibits pathological angiogenesis F Zhang, Z Tang, X Hou, J Lennartsson, Y Li, AW Koch, P Scotney, C Lee, ... Proceedings of the National Academy of Sciences 106 (15), 6152-6157, 2009 | 351 | 2009 |
Transferrin receptor (TfR) trafficking determines brain uptake of TfR antibody affinity variants N Bien-Ly, YJ Yu, D Bumbaca, J Elstrott, CA Boswell, Y Zhang, W Luk, ... Journal of Experimental Medicine 211 (2), 233-244, 2014 | 325 | 2014 |
A therapeutic antibody targeting BACE1 inhibits amyloid-β production in vivo JK Atwal, Y Chen, C Chiu, DL Mortensen, WJ Meilandt, Y Liu, CE Heise, ... Science translational medicine 3 (84), 84ra43-84ra43, 2011 | 299 | 2011 |
Effect of selective LRRK2 kinase inhibition on nonhuman primate lung RN Fuji, M Flagella, M Baca, MA S. Baptista, J Brodbeck, BK Chan, ... Science translational medicine 7 (273), 273ra15-273ra15, 2015 | 292 | 2015 |
Wlds protection distinguishes axon degeneration following injury from naturally occurring developmental pruning ED Hoopfer, T McLaughlin, RJ Watts, O Schuldiner, DDM O'Leary, L Luo Neuron 50 (6), 883-895, 2006 | 283 | 2006 |
Neuropilin-1 binds to VEGF121 and regulates endothelial cell migration and sprouting Q Pan, Y Chathery, Y Wu, N Rathore, RK Tong, F Peale, A Bagri, ... Journal of Biological Chemistry 282 (33), 24049-24056, 2007 | 267 | 2007 |
Effector-attenuating substitutions that maintain antibody stability and reduce toxicity in mice M Lo, HS Kim, RK Tong, TW Bainbridge, JM Vernes, Y Zhang, YL Lin, ... Journal of Biological Chemistry 292 (9), 3900-3908, 2017 | 259 | 2017 |