Chao Zhang
Chao Zhang
Professor of Chemistry, University of Southern California
Verified email at
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RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF
PI Poulikakos, C Zhang, G Bollag, KM Shokat, N Rosen
Nature 464 (7287), 427-430, 2010
IRE1 signaling affects cell fate during the unfolded protein response
JH Lin, H Li, D Yasumura, HR Cohen, C Zhang, B Panning, KM Shokat, ...
science 318 (5852), 944-949, 2007
Structural bioinformatics-based design of selective, irreversible kinase inhibitors
MS Cohen, C Zhang, KM Shokat, J Taunton
Science 308 (5726), 1318-1321, 2005
The unfolded protein response signals through high-order assembly of Ire1
AV Korennykh, PF Egea, AA Korostelev, J Finer-Moore, C Zhang, ...
Nature 457 (7230), 687-693, 2009
Chemical genetic analysis of the time course of signal transduction by JNK
JJ Ventura, A Hübner, C Zhang, RA Flavell, KM Shokat, RJ Davis
Molecular cell 21 (5), 701-710, 2006
An unbiased cell morphology–based screen for new, biologically active small molecules
M Tanaka, R Bateman, D Rauh, E Vaisberg, S Ramachandani, C Zhang, ...
PLoS Biol 3 (5), e128, 2005
Calcium-dependent protein kinase 1 is an essential regulator of exocytosis in Toxoplasma
S Lourido, J Shuman, C Zhang, KM Shokat, R Hui, LD Sibley
Nature 465 (7296), 359-362, 2010
Control of landmark events in meiosis by the CDK Cdc28 and the meiosis-specific kinase Ime2
KR Benjamin, C Zhang, KM Shokat, I Herskowitz
Genes & development 17 (12), 1524-1539, 2003
TFIIH-associated Cdk7 kinase functions in phosphorylation of C-terminal domain Ser7 residues, promoter-proximal pausing, and termination by RNA polymerase II
K Glover-Cutter, S Larochelle, B Erickson, C Zhang, K Shokat, RP Fisher, ...
Molecular and cellular biology 29 (20), 5455-5464, 2009
Inhibitor hijacking of Akt activation
T Okuzumi, D Fiedler, C Zhang, DC Gray, B Aizenstein, R Hoffman, ...
Nature chemical biology 5 (7), 484-493, 2009
Bypassing a kinase activity with an ATP-competitive drug
FR Papa, C Zhang, K Shokat, P Walter
Science 302 (5650), 1533-1537, 2003
Chemical genetics reveals the requirement for Polo-like kinase 1 activity in positioning RhoA and triggering cytokinesis in human cells
ME Burkard, CL Randall, S Larochelle, C Zhang, KM Shokat, RP Fisher, ...
Proceedings of the National Academy of Sciences 104 (11), 4383-4388, 2007
Cyclin-dependent kinase control of the initiation-to-elongation switch of RNA polymerase II
S Larochelle, R Amat, K Glover-Cutter, M Sansó, C Zhang, JJ Allen, ...
Nature structural & molecular biology 19 (11), 1108, 2012
A chemical-genetic approach to studying neurotrophin signaling
X Chen, H Ye, R Kuruvilla, N Ramanan, KW Scangos, C Zhang, ...
Neuron 46 (1), 13-21, 2005
The Saccharomyces cerevisiae Mob2p–Cbk1p kinase complex promotes polarized growth and acts with the mitotic exit network to facilitate daughter cell–specific localization of …
EL Weiss, C Kurischko, C Zhang, K Shokat, DG Drubin, FC Luca
The Journal of cell biology 158 (5), 885-900, 2002
Requirements for Cdk7 in the assembly of Cdk1/cyclin B and activation of Cdk2 revealed by chemical genetics in human cells
S Larochelle, KA Merrick, ME Terret, L Wohlbold, NM Barboza, C Zhang, ...
Molecular cell 25 (6), 839-850, 2007
Mps1 directs the assembly of Cdc20 inhibitory complexes during interphase and mitosis to control M phase timing and spindle checkpoint signaling
J Maciejowski, KA George, ME Terret, C Zhang, KM Shokat, PV Jallepalli
Journal of Cell Biology 190 (1), 89-100, 2010
Structure-guided development of affinity probes for tyrosine kinases using chemical genetics
JA Blair, D Rauh, C Kung, CH Yun, QW Fan, H Rode, C Zhang, MJ Eck, ...
Nature Chemical Biology 3 (4), 229-238, 2007
Chemical genetic analysis of Apg1 reveals a non-kinase role in the induction of autophagy
H Abeliovich, C Zhang, WA Dunn Jr, KM Shokat, DJ Klionsky
Molecular biology of the cell 14 (2), 477-490, 2003
An integrated platform of genomic assays reveals small-molecule bioactivities
S Hoon, AM Smith, IM Wallace, S Suresh, M Miranda, E Fung, M Proctor, ...
Nature chemical biology 4 (8), 498-506, 2008
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