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Niklas Hartung
Niklas Hartung
Univerity of Potsdam
Verified email at uni-potsdam.de
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Year
Mathematical modeling of tumor growth and metastatic spreading: validation in tumor-bearing mice
N Hartung, S Mollard, D Barbolosi, A Benabdallah, G Chapuisat, G Henry, ...
Cancer research 74 (22), 6397-6407, 2014
1222014
Role of renal function in risk assessment of target non-attainment after standard dosing of meropenem in critically ill patients: a prospective observational study
L Ehmann, M Zoller, IK Minichmayr, C Scharf, B Maier, MV Schmitt, ...
Critical care 21, 1-14, 2017
682017
Bayesian data assimilation to support informed decision making in individualized chemotherapy
C Maier, N Hartung, J de Wiljes, C Kloft, W Huisinga
CPT: pharmacometrics & systems pharmacology 9 (3), 153-164, 2020
312020
Reinforcement learning and Bayesian data assimilation for model‐informed precision dosing in oncology
C Maier, N Hartung, C Kloft, W Huisinga, J de Wiljes
CPT: pharmacometrics & systems pharmacology 10 (3), 241-254, 2021
262021
Pharmacokinetic/pharmacodynamic evaluation of hydrocortisone therapy in pediatric patients with congenital adrenal hyperplasia
J Melin, ZP Parra-Guillen, R Michelet, T Truong, W Huisinga, N Hartung, ...
The Journal of Clinical Endocrinology & Metabolism 105 (4), e1729-e1740, 2020
252020
Efficient resolution of metastatic tumour growth models by reformulation into integral equations
N Hartung
242014
Predicting cortisol exposure from paediatric hydrocortisone formulation using a semi-mechanistic pharmacokinetic model established in healthy adults
J Melin, ZP Parra-Guillen, N Hartung, W Huisinga, RJ Ross, MJ Whitaker, ...
Clinical Pharmacokinetics 57, 515-527, 2018
212018
Paracrine and autocrine regulation of gene expression by Wnt-inhibitor Dickkopf in wild-type and mutant hepatocytes
N Hartung, U Benary, J Wolf, B Kofahl
BMC Systems Biology 11, 1-16, 2017
132017
A continued learning approach for model‐informed precision dosing: updating models in clinical practice
C Maier, J de Wiljes, N Hartung, C Kloft, W Huisinga
CPT: pharmacometrics & systems pharmacology 11 (2), 185-198, 2022
122022
Model description language (MDL): a standard for modeling and simulation
MK Smith, SL Moodie, R Bizzotto, E Blaudez, E Borella, L Carrara, ...
CPT: pharmacometrics & systems pharmacology 6 (10), 647, 2017
122017
Study of metastatic kinetics in metastatic melanoma treated with B-RAF inhibitors: Introducing mathematical modelling of kinetics into the therapeutic decision
N Hartung, CTK Huynh, C Gaudy-Marqueste, A Flavian, N Malissen, ...
PLoS One 12 (5), e0176080, 2017
122017
The circadian rhythm of corticosteroid‐binding globulin has little impact on cortisol exposure after hydrocortisone dosing
J Melin, N Hartung, ZP Parra‐Guillen, MJ Whitaker, RJ Ross, C Kloft
Clinical endocrinology 91 (1), 33-40, 2019
102019
Physiology-based toxicokinetic modelling of aluminium in rat and man
C Hethey, N Hartung, G Wangorsch, K Weisser, W Huisinga
Archives of Toxicology 95 (9), 2977-3000, 2021
92021
Parameter non-identifiability of the Gyllenberg–Webb ODE model
N Hartung
Journal of mathematical biology 68, 41-55, 2014
72014
A mechanistic framework for a priori pharmacokinetic predictions of orally inhaled drugs
N Hartung, JM Borghardt
PLoS Computational Biology 16 (12), e1008466, 2020
62020
Time-to-event analysis of paclitaxel-associated peripheral neuropathy in advanced non–small-cell lung cancer highlighting key influential treatment/patient factors
FW Ojara, A Henrich, N Frances, W Huisinga, N Hartung, M Joerger, ...
Journal of Pharmacology and Experimental Therapeutics 375 (3), 430-438, 2020
62020
An efficient implementation of a 3D CeVeFE DDFV scheme on cartesian grids and an application in image processing
N Hartung, F Hubert
Finite Volumes for Complex Applications VII-Elliptic, Parabolic and …, 2014
52014
A prognostic baseline blood biomarker and tumor growth kinetics integrated model in paclitaxel/platinum treated advanced non‐small cell lung cancer patients
FW Ojara, A Henrich, N Frances, YM Nassar, W Huisinga, N Hartung, ...
CPT: Pharmacometrics & Systems Pharmacology 12 (11), 1714-1725, 2023
42023
Stochastic and deterministic models for the metastatic emission process: formalisms and crosslinks
C Gomez, N Hartung
Cancer Systems Biology: Methods and Protocols, 193-224, 2018
32018
Nonparametric goodness‐of‐fit testing for parametric covariate models in pharmacometric analyses
N Hartung, M Wahl, A Rastogi, W Huisinga
CPT: Pharmacometrics & Systems Pharmacology 10 (6), 564-576, 2021
22021
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Articles 1–20