Thomas Helleday
Thomas Helleday
Zweryfikowany adres z ki.se - Strona główna
Cytowane przez
Cytowane przez
Specific killing of BRCA2-deficient tumours with inhibitors of poly (ADP-ribose) polymerase
HE Bryant, N Schultz, HD Thomas, KM Parker, D Flower, E Lopez, S Kyle, ...
Nature 434 (7035), 913-917, 2005
Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints
J Bartkova, N Rezaei, M Liontos, P Karakaidos, D Kletsas, N Issaeva, ...
Nature 444 (7119), 633-637, 2006
DNA repair pathways as targets for cancer therapy
T Helleday, E Petermann, C Lundin, B Hodgson, RA Sharma
Nature Reviews Cancer 8 (3), 193-204, 2008
Mechanisms underlying mutational signatures in human cancers
T Helleday, S Eshtad, S Nik-Zainal
Nature reviews genetics 15 (9), 585-598, 2014
The underlying mechanism for the PARP and BRCA synthetic lethality: clearing up the misunderstandings
T Helleday
Molecular oncology 5 (4), 387-393, 2011
Replication stress links structural and numerical cancer chromosomal instability
RA Burrell, SE McClelland, D Endesfelder, P Groth, MC Weller, N Shaikh, ...
Nature 494 (7438), 492-496, 2013
Hydroxyurea-stalled replication forks become progressively inactivated and require two different RAD51-mediated pathways for restart and repair
E Petermann, ML Orta, N Issaeva, N Schultz, T Helleday
Molecular cell 37 (4), 492-502, 2010
DNA double-strand break repair: from mechanistic understanding to cancer treatment
T Helleday, J Lo, DC van Gent, BP Engelward
DNA repair 6 (7), 923-935, 2007
The cell-cycle checkpoint kinase Chk1 is required for mammalian homologous recombination repair
CS Sørensen, LT Hansen, J Dziegielewski, RG Syljuåsen, C Lundin, ...
Nature cell biology 7 (2), 195-201, 2005
PARP is activated at stalled forks to mediate Mre11‐dependent replication restart and recombination
HE Bryant, E Petermann, N Schultz, AS Jemth, O Loseva, N Issaeva, ...
The EMBO journal 28 (17), 2601-2615, 2009
Inhibition of human Chk1 causes increased initiation of DNA replication, phosphorylation of ATR targets, and DNA breakage
RG Syljuåsen, CS Sørensen, LT Hansen, K Fugger, C Lundin, ...
Molecular and cellular biology, 2005
MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool
H Gad, T Koolmeister, AS Jemth, S Eshtad, SA Jacques, CE Ström, ...
Nature 508 (7495), 215-221, 2014
miR-182-mediated downregulation of BRCA1 impacts DNA repair and sensitivity to PARP inhibitors
P Moskwa, FM Buffa, Y Pan, R Panchakshari, P Gottipati, RJ Muschel, ...
Molecular cell 41 (2), 210-220, 2011
DNA double-strand breaks associated with replication forks are predominantly repaired by homologous recombination involving an exchange mechanism in mammalian cells
C Arnaudeau, C Lundin, T Helleday
Journal of molecular biology 307 (5), 1235-1245, 2001
Methyl methanesulfonate (MMS) produces heat-labile DNA damage but no detectable in vivo DNA double-strand breaks
C Lundin, M North, K Erixon, K Walters, D Jenssen, ASH Goldman, ...
Nucleic acids research 33 (12), 3799-3811, 2005
Break-induced replication repair of damaged forks induces genomic duplications in human cells
L Costantino, SK Sotiriou, JK Rantala, S Magin, E Mladenov, T Helleday, ...
Science 343 (6166), 88-91, 2014
Defective DNA single-strand break repair in spinocerebellar ataxia with axonal neuropathy-1
SF El-Khamisy, GM Saifi, M Weinfeld, F Johansson, T Helleday, JR Lupski, ...
Nature 434 (7029), 108-113, 2005
SETD2-dependent histone H3K36 trimethylation is required for homologous recombination repair and genome stability
SX Pfister, S Ahrabi, LP Zalmas, S Sarkar, F Aymard, CZ Bachrati, ...
Cell reports 7 (6), 2006-2018, 2014
Conservative homologous recombination preferentially repairs DNA double-strand breaks in the S phase of the cell cycle in human cells
N Saleh-Gohari, T Helleday
Nucleic acids research 32 (12), 3683-3688, 2004
Spatial maps of prostate cancer transcriptomes reveal an unexplored landscape of heterogeneity
E Berglund, J Maaskola, N Schultz, S Friedrich, M Marklund, ...
Nature communications 9 (1), 2419, 2018
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