Natural polyphenols inhibit different steps of the process of transthyretin (TTR) amyloid fibril formation N Ferreira, MJ Saraiva, MR Almeida FEBS letters 585 (15), 2424-2430, 2011 | 186 | 2011 |
Binding of epigallocatechin-3-gallate to transthyretin modulates its amyloidogenicity N Ferreira, I Cardoso, MR Domingues, R Vitorino, M Bastos, G Bai, ... FEBS letters 583 (22), 3569-3576, 2009 | 159 | 2009 |
Repositioning tolcapone as a potent inhibitor of transthyretin amyloidogenesis and associated cellular toxicity R Sant'Anna, P Gallego, LZ Robinson, A Pereira-Henriques, N Ferreira, ... Nature communications 7 (1), 10787, 2016 | 157 | 2016 |
Transthyretin amyloidosis: a tale of weak interactions MJM Saraiva FEBS letters 498 (2-3), 201-203, 2001 | 131 | 2001 |
Transthyretin, a new cryptic protease MA Liz, CJ Faro, MJ Saraiva, MM Sousa Journal of Biological Chemistry 279 (20), 21431-21438, 2004 | 130 | 2004 |
The amyloidogenic potential of transthyretin variants correlates with their tendency to aggregate in solution A Quintas, MJM Saraiva, RMM Brito Febs Letters 418 (3), 297-300, 1997 | 129 | 1997 |
Selective binding to transthyretin and tetramer stabilization in serum from patients with familial amyloidotic polyneuropathy by an iodinated diflunisal derivative MR Almeida, B Macedo, I Cardoso, I Alves, G Valencia, G Arsequell, ... Biochemical Journal 381 (2), 351-356, 2004 | 115 | 2004 |
Portuguese family with the co-occurrence of frontotemporal lobar degeneration and neuronal ceroid lipofuscinosis phenotypes due to progranulin gene mutation MR Almeida, MC Macário, L Ramos, I Baldeiras, MH Ribeiro, I Santana Neurobiology of aging 41, 200. e1-200. e5, 2016 | 114 | 2016 |
Epigallocatechin-3-gallate as a potential therapeutic drug for TTR-related amyloidosis:“in vivo” evidence from FAP mice models N Ferreira, MJ Saraiva, MR Almeida PloS one 7 (1), e29933, 2012 | 114 | 2012 |
Thyroxine binding to transthyretin Met 119: Comparative studies of different heterozygotic carriers and structural analysis MR Almeida, AM Damas, MC Lans, A Brouwer, MJ Saraiva Endocrine 6, 309-315, 1997 | 104 | 1997 |
A strikingly benign evolution of FAP in an individual found to be a compound heterozygote for two TTR mutations: TTR MET 30 and TTR MET 119 T Coelho, M Carvalho, MJ Saraiva, I Alves, MR Almeida, PP Costa J rheumatol 20, 179, 1993 | 93 | 1993 |
Prevalence and characteristics of new‐onset pain in COVID‐19 survivours, a controlled study FHC Soares, GT Kubota, AM Fernandes, B Hojo, C Couras, BV Costa, ... European Journal of Pain 25 (6), 1342-1354, 2021 | 82 | 2021 |
Anti-apoptotic treatment reduces transthyretin deposition in a transgenic mouse model of Familial Amyloidotic Polyneuropathy B Macedo, AR Batista, N Ferreira, MR Almeida, MJ Saraiva Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease 1782 (9), 517-522, 2008 | 81 | 2008 |
Cardiac amyloidosis: a review and report of a new transthyretin (prealbumin) variant. A Hesse, K Altland, RP Linke, MR Almeida, MJ Saraiva, A Steinmetz, ... Heart 70 (2), 111-115, 1993 | 70 | 1993 |
Isatin derivatives, a novel class of transthyretin fibrillogenesis inhibitors A González, J Quirante, J Nieto, MR Almeida, MJ Saraiva, A Planas, ... Bioorganic & medicinal chemistry letters 19 (17), 5270-5273, 2009 | 66 | 2009 |
Iodine atoms: a new molecular feature for the design of potent transthyretin fibrillogenesis inhibitors T Mairal, J Nieto, M Pinto, MR Almeida, L Gales, A Ballesteros, ... PLoS One 4 (1), e4124, 2009 | 65 | 2009 |
Dietary curcumin counteracts extracellular transthyretin deposition: insights on the mechanism of amyloid inhibition N Ferreira, SAO Santos, MRM Domingues, MJ Saraiva, MR Almeida Biochimica Et Biophysica Acta (BBA)-Molecular Basis of Disease 1832 (1), 39-45, 2013 | 61 | 2013 |
Screening and biochemical characterization of transthyretin variants in the Portuguese population IL Alves, K Altland, MR Almeida, P Winter, MJM Saraiva Human Mutation 9 (3), 226-233, 1997 | 61 | 1997 |
Interaction with human plasminogen system turns on proteolytic activity in Streptococcus agalactiae and enhances its virulence in a mouse model V Magalhaes, I Veiga-Malta, MR Almeida, M Baptista, A Ribeiro, ... Microbes and infection 9 (11), 1276-1284, 2007 | 56 | 2007 |
Two transthyretin variants (TTR Ala‐49 and TTR Gln‐89) in two Sicilian kindreds with hereditary amyloidosis MR Almeida, A Ferlini, A Forabosco, M Gawinowicz, PP Costa, F Salvi, ... Human Mutation 1 (3), 211-215, 1992 | 53 | 1992 |