|Regional blood flow in the normal and ischemic brain is controlled by arteriolar smooth muscle cell contractility and not by capillary pericytes|
RA Hill*, L Tong*, P Yuan*, S Murikinati, S Gupta, J Grutzendler
Neuron 87 (1), 95-110, 2015
|TREM2 haplodeficiency in mice and humans impairs the microglia barrier function leading to decreased amyloid compaction and severe axonal dystrophy|
P Yuan, C Condello, CD Keene, Y Wang, TD Bird, SM Paul, W Luo, ...
Neuron 90 (4), 724-739, 2016
|TREM2-mediated early microglial response limits diffusion and toxicity of amyloid plaques|
Y Wang, TK Ulland, JD Ulrich, W Song, JA Tzaferis, JT Hole, P Yuan, ...
Journal of Experimental Medicine 213 (5), 667-675, 2016
|Microglia constitute a barrier that prevents neurotoxic protofibrillar Aβ42 hotspots around plaques|
C Condello*, P Yuan*, A Schain, J Grutzendler
Nature communications 6, 6176, 2015
|Massive accumulation of luminal protease-deficient axonal lysosomes at Alzheimer’s disease amyloid plaques|
S Gowrishankar, P Yuan, Y Wu, M Schrag, S Paradise, J Grutzendler, ...
Proceedings of the National Academy of Sciences 112 (28), E3699-E3708, 2015
|Increased nanoparticle delivery to brain tumors by autocatalytic priming for improved treatment and imaging|
L Han, DK Kong, M Zheng, S Murikinati, C Ma, P Yuan, L Li, D Tian, Q Cai, ...
ACS nano 10 (4), 4209-4218, 2016
|Angiophagy prevents early embolus washout but recanalizes microvessels through embolus extravasation|
J Grutzendler, S Murikinati, B Hiner, L Ji, CK Lam, T Yoo, S Gupta, ...
Science translational medicine 6 (226), 226ra31-226ra31, 2014
|Microglia-mediated neuroprotection, TREM2 and Alzheimer’s disease: Evidence from Optical Imaging|
C Condello*, P Yuan*, J Grutzendler
Biological Psychiatry, 2017
|Attenuation of β-amyloid deposition and neurotoxicity by chemogenetic modulation of neural activity|
P Yuan, J Grutzendler
Journal of Neuroscience 36 (2), 632-641, 2016
|A bifunctional curcumin analogue for two-photon imaging and inhibiting crosslinking of amyloid beta in Alzheimer's disease|
X Zhang, Y Tian, P Yuan, Y Li, MA Yaseen, J Grutzendler, A Moore, ...
Chemical communications 50 (78), 11550-11553, 2014
|Oxalate-curcumin–based probe for micro-and macroimaging of reactive oxygen species in Alzheimer’s disease|
J Yang*, X Zhang*, P Yuan*, J Yang, Y Xu, J Grutzendler, Y Shao, ...
Proceedings of the National Academy of Sciences 114 (47), 12384-12389, 2017
|Bacterial melanin interacts with double-stranded DNA with high affinity and may inhibit cell metabolism in vivo|
J Geng*, P Yuan*, C Shao, SB Yu, B Zhou, P Zhou, XD Chen
Archives of microbiology 192 (5), 321-329, 2010
|Luteolin reduces BACE1 expression through NF-κB and estrogen receptor mediated pathways in HEK293 and SH-SY5Y cells|
N Zheng, P Yuan, C Li, J Wu, J Huang
Journal of Alzheimer's Disease 45 (2), 659-671, 2015
|Multiple‐targeting and conformational selection in the estrogen receptor: computation and experiment|
P Yuan, K Liang, B Ma, N Zheng, R Nussinov, J Huang
Chemical biology & drug design 78 (1), 137-149, 2011
|RecV recombinase system for in vivo targeted optogenomic modifications of single cells or cell populations|
S Yao*, P Yuan*, B Ouellette, T Zhou, M Mortrud, P Balaram, S Chatterjee, ...
Nature Methods 17, 422–429, 2020
|Estrogen regulates excitatory amino acid carrier 1 (EAAC1) expression through sphingosine kinase 1 (SphK1) transacting FGFR-mediated ERK signaling in rat C6 astroglial cells|
C Huang, P Yuan, J Wu, J Huang
Neuroscience 319, 9-22, 2016
|Absolute two-photon excitation spectra of red and far-red fluorescent probes|
MGM Velasco, ES Allgeyer, P Yuan, J Grutzendler, J Bewersdorf
Optics letters 40 (21), 4915-4918, 2015
|3D super-resolution deep-tissue imaging in living mice|
MGM Velasco, M Zhang, J Antonello, P Yuan, ES Allgeyer, D May, ...
Optica 8 (4), 442-450, 2021
|Imaging and optogenetic modulation of vascular mural cells in the live brain|
L Tong, RA Hill, EC Damisah, KN Murray, P Yuan, A Bordey, ...
Nature Protocols 16 (1), 472-496, 2021
|O1‐12‐04: Near Infrared Fluorescence Imaging of Reactive Oxygen Species in Alzheimer’s Disease Via Transformation From “Visible” to “Invisible”|
C Ran, J Yang, J Yang, P Yuan, J Grutzendler, Y Xu
Alzheimer's & Dementia 12, P206-P206, 2016