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Sven Lang
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BiP‐mediated closing of the Sec61 channel limits Ca2+ leakage from the ER
N Schäuble, S Lang, M Jung, S Cappel, S Schorr, Ö Ulucan, J Linxweiler, ...
The EMBO journal 31 (15), 3282-3296, 2012
1942012
Different effects of Sec61α, Sec62 and Sec63 depletion on transport of polypeptides into the endoplasmic reticulum of mammalian cells
S Lang, J Benedix, SV Fedeles, S Schorr, C Schirra, N Schäuble, C Jalal, ...
Journal of cell science 125 (8), 1958-1969, 2012
1932012
Structure of the mammalian oligosaccharyl-transferase complex in the native ER protein translocon
S Pfeffer, J Dudek, M Gogala, S Schorr, J Linxweiler, S Lang, T Becker, ...
Nature communications 5 (1), 3072, 2014
1742014
An update on Sec61 channel functions, mechanisms, and related diseases
S Lang, S Pfeffer, PH Lee, A Cavalié, V Helms, F Förster, R Zimmermann
Frontiers in physiology 8, 887, 2017
1562017
Interaction of calmodulin with Sec61α limits Ca2+ leakage from the endoplasmic reticulum
F Erdmann, N Schäuble, S Lang, M Jung, A Honigmann, M Ahmad, ...
The EMBO journal 30 (1), 17-31, 2011
1292011
Sec61 complexes form ubiquitous ER Ca2+ leak channels
S Lang, F Erdmann, M Jung, R Wagner, A Cavalie, R Zimmermann
Channels 5 (3), 228-235, 2011
1092011
Structure and 3D arrangement of endoplasmic reticulum membrane-associated ribosomes
S Pfeffer, F Brandt, T Hrabe, S Lang, M Eibauer, R Zimmermann, F Förster
Structure 20 (9), 1508-1518, 2012
1062012
A Drosophila model identifies a critical role for zinc in mineralization for kidney stone disease
T Chi, MS Kim, S Lang, N Bose, A Kahn, L Flechner, SD Blaschko, T Zee, ...
PloS one 10 (5), e0124150, 2015
842015
TRC40 can deliver short secretory proteins to the Sec61 translocon
N Johnson, F Vilardi, S Lang, P Leznicki, R Zimmermann, S High
Journal of cell science 125 (15), 3612-3620, 2012
822012
Proteomics reveals signal peptide features determining the client specificity in human TRAP-dependent ER protein import
D Nguyen, R Stutz, S Schorr, S Lang, S Pfeffer, HH Freeze, F Förster, ...
Nature communications 9 (1), 3765, 2018
752018
hS nd2 protein represents an alternative targeting factor to the endoplasmic reticulum in human cells
S Haßdenteufel, M Sicking, S Schorr, N Aviram, C Fecher‐Trost, ...
FEBS letters 591 (20), 3211-3224, 2017
722017
AXER is an ATP/ADP exchanger in the membrane of the endoplasmic reticulum
MC Klein, K Zimmermann, S Schorr, M Landini, PAW Klemens, J Altensell, ...
Nature communications 9 (1), 3489, 2018
622018
Sec62 protein level is crucial for the ER stress tolerance of prostate cancer
M Greiner, B Kreutzer, S Lang, V Jung, A Cavalié, G Unteregger, ...
The Prostate 71 (10), 1074-1083, 2011
522011
A conserved role of the insulin-like signaling pathway in diet-dependent uric acid pathologies in Drosophila melanogaster
S Lang, TA Hilsabeck, KA Wilson, A Sharma, N Bose, DJ Brackman, ...
PLoS genetics 15 (8), e1008318, 2019
492019
Structural features within the nascent chain regulate alternative targeting of secretory proteins to mitochondria
NV Pfeiffer, D Dirndorfer, S Lang, UK Resenberger, LM Restelli, ...
The EMBO journal 32 (7), 1036-1051, 2013
442013
Defective Sec61α1 underlies a novel cause of autosomal dominant severe congenital neutropenia
E Van Nieuwenhove, JS Barber, J Neumann, E Smeets, M Willemsen, ...
Journal of Allergy and Clinical Immunology 146 (5), 1180-1193, 2020
412020
Identification of signal peptide features for substrate specificity in human Sec62/Sec63‐dependent ER protein import
S Schorr, D Nguyen, S Haßdenteufel, N Nagaraj, A Cavalié, M Greiner, ...
The FEBS journal 287 (21), 4612-4640, 2020
382020
Complexity and specificity of Sec61-channelopathies: human diseases affecting gating of the Sec61 complex
M Sicking, S Lang, F Bochen, A Roos, JPH Drenth, M Zakaria, ...
Cells 10 (5), 1036, 2021
352021
Live cell calcium imaging combined with siRNA mediated gene silencing identifies Ca2+ leak channels in the ER membrane and their regulatory mechanisms
S Lang, N Schäuble, A Cavalié, R Zimmermann
JoVE (Journal of Visualized Experiments), e2730, 2011
302011
Lanthanum ions inhibit the mammalian Sec61 complex in its channel dynamics and protein transport activity
F Erdmann, M Jung, S Eyrisch, S Lang, V Helms, R Wagner, ...
FEBS letters 583 (14), 2359-2364, 2009
272009
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