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Wfs1-deficient rats develop primary symptoms of Wolfram syndrome: insulin-dependent diabetes, optic nerve atrophy and medullary degeneration
M Plaas, K Seppa, R Reimets, T Jagomäe, M Toots, T Koppel, T Vallisoo, ...
Scientific reports 7 (1), 10220, 2017
482017
Neural cell adhesion molecule Negr1 deficiency in mouse results in structural brain endophenotypes and behavioral deviations related to psychiatric disorders
K Singh, M Jayaram, M Kaare, E Leidmaa, T Jagomäe, I Heinla, ...
Scientific reports 9 (1), 5457, 2019
452019
GLP-1 receptor agonist liraglutide has a neuroprotective effect on an aged rat model of Wolfram syndrome
K Seppa, M Toots, R Reimets, T Jagomäe, T Koppel, M Pallase, ...
Scientific Reports 9 (1), 15742, 2019
382019
Preventive treatment with liraglutide protects against development of glucose intolerance in a rat model of Wolfram syndrome
M Toots, K Seppa, T Jagomäe, T Koppel, M Pallase, I Heinla, A Terasmaa, ...
Scientific reports 8 (1), 10183, 2018
382018
Liraglutide, 7, 8-DHF and their co-treatment prevents loss of vision and cognitive decline in a Wolfram syndrome rat model
K Seppa, T Jagomäe, KG Kukker, R Reimets, M Pastak, E Vasar, ...
Scientific Reports 11 (1), 2275, 2021
232021
Early intervention and lifelong treatment with GLP1 receptor agonist liraglutide in a Wolfram syndrome rat model with an emphasis on visual neurodegeneration, sensorineural …
T Jagomäe, K Seppa, R Reimets, M Pastak, M Plaas, MA Hickey, ...
Cells 10 (11), 3193, 2021
162021
Alternative promoter use governs the expression of IgLON cell adhesion molecules in histogenetic fields of the embryonic mouse brain
T Jagomäe, K Singh, MA Philips, M Jayaram, K Seppa, T Tekko, ...
International Journal of Molecular Sciences 22 (13), 6955, 2021
82021
Chronic alcohol use induces molecular genetic changes in the dorsomedial thalamus of people with alcohol-related disorders
AC Hade, MA Philips, E Reimann, T Jagomäe, KL Eskla, T Traks, E Prans, ...
Brain Sciences 11 (4), 435, 2021
82021
Expression and impact of Lsamp neural adhesion molecule in the serotonergic neurotransmission system
A Bregin, M Kaare, T Jagomäe, K Karis, K Singh, K Laugus, J Innos, ...
Pharmacology Biochemistry and Behavior 198, 173017, 2020
72020
Wfs1 is expressed in dopaminoceptive regions of the amniote brain and modulates levels of D1-like receptors
T Tekko, T Lakspere, A Allikalt, J End, KR Kolvart, T Jagomäe, ...
PloS one 12 (3), e0172825, 2017
62017
High-fat diet induces pre-diabetes and distinct sex-specific metabolic alterations in negr1-deficient mice
M Kaare, K Mikheim, K Lilleväli, K Kilk, T Jagomäe, E Leidmaa, M Piirsalu, ...
Biomedicines 9 (9), 1148, 2021
52021
Hypothermia alleviates reductive stress, a root cause of ischemia reperfusion injury
KL Eskla, H Vellama, L Tarve, H Eichelmann, T Jagomäe, R Porosk, V Oja, ...
International Journal of Molecular Sciences 23 (17), 10108, 2022
42022
Depression-Associated Negr1 Gene-Deficiency Induces Alterations in the Monoaminergic Neurotransmission Enhancing Time-Dependent Sensitization to …
M Kaare, M Jayaram, T Jagomäe, K Singh, K Kilk, K Mikheim, M Leevik, ...
Brain Sciences 12 (12), 1696, 2022
22022
The Expression of RAAS Key Receptors, Agtr2 and Bdkrb1, Is Downregulated at an Early Stage in a Rat Model of Wolfram Syndrome
M Punapart, K Seppa, T Jagomäe, M Liiv, R Reimets, S Kirillov, A Kaasik, ...
Genes 12 (11), 1717, 2021
22021
A cost-effective and efficient ex vivo, ex situ human whole brain perfusion protocol for immunohistochemistry
AC Hade, MA Philips, L Promet, T Jagomäe, A Hanumantharaju, ...
Journal of Neuroscience Methods 404, 110059, 2024
12024
Chronic stress alters hippocampal renin-angiotensin-aldosterone system component expression in an aged rat model of wolfram syndrome
M Punapart, R Reimets, K Seppa, S Kirillov, N Gaur, KL Eskla, T Jagomäe, ...
Genes 14 (4), 827, 2023
12023
High‐throughput proteomic analysis of chronic inflammatory skin diseases: Psoriasis and atopic dermatitis
T Traks, P Reemann, KL Eskla, A Ottas, T Jagomäe, R Liira, L Ilves, ...
Experimental Dermatology 33 (4), e15079, 2024
2024
VHL-deficiency leads to reductive stress in renal cells
H Vellama, KL Eskla, H Eichelmann, A Hüva, DA Tennant, A Thakker, ...
Free Radical Biology and Medicine 208, 1-12, 2023
2023
Treatment with the dual-incretin agonist DA-CH5 demonstrates potent therapeutic effect in a rat model of Wolfram Syndrome
T Jagomäe, N Gaur, K Seppa, R Reimets, M Pastak, M Plaas, A Kaasik, ...
Frontiers in Endocrinology 14, 1234925, 2023
2023
Chronic Alcohol Use Induces Molecular Genetic Changes in the Dorsomedial Thalamus of People with Alcohol-Related Disorders. Brain Sci. 2021, 11, 435
AC Hade, MA Philips, E Reimann, T Jagomäe, KL Eskla, T Traks, E Prans, ...
s Note: MDPI stays neutral with regard to jurisdictional claims in published …, 2021
2021
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