The promise and peril of chemical probes CH Arrowsmith, JE Audia, C Austin, J Baell, J Bennett, J Blagg, C Bountra, ... Nature chemical biology 11 (8), 536-541, 2015 | 832 | 2015 |
Comprehensive characterization of the published kinase inhibitor set JM Elkins, V Fedele, M Szklarz, KR Abdul Azeez, E Salah, J Mikolajczyk, ... Nature biotechnology 34 (1), 95-103, 2016 | 337 | 2016 |
Tandem ring opening− ring closing metathesis of cyclic olefins WJ Zuercher, M Hashimoto, RH Grubbs Journal of the American Chemical Society 118 (28), 6634-6640, 1996 | 313 | 1996 |
Catalytic Ring Closing Metathesis of Dienynes: Construction of Fused Bicyclic [n. m. 0] Rings SH Kim, WJ Zuercher, NB Bowden, RH Grubbs The Journal of Organic Chemistry 61 (3), 1073-1081, 1996 | 237 | 1996 |
Estrogen-related receptor-α is a metabolic regulator of effector T-cell activation and differentiation RD Michalek, VA Gerriets, AG Nichols, M Inoue, D Kazmin, CY Chang, ... Proceedings of the National Academy of Sciences 108 (45), 18348-18353, 2011 | 234 | 2011 |
A public-private partnership to unlock the untargeted kinome S Knapp, P Arruda, J Blagg, S Burley, DH Drewry, A Edwards, D Fabbro, ... Nature chemical biology 9 (1), 3-6, 2013 | 172 | 2013 |
An efficient, general asymmetric synthesis of carbocyclic nucleosides: application of an asymmetric aldol/ring-closing metathesis strategy MT Crimmins, BW King, WJ Zuercher, AL Choy The Journal of Organic Chemistry 65 (25), 8499-8509, 2000 | 172 | 2000 |
The metabolic regulator ERRα, a downstream target of HER2/IGF-1R, as a therapeutic target in breast cancer C Chang, D Kazmin, JS Jasper, R Kunder, WJ Zuercher, DP McDonnell Cancer cell 20 (4), 500-510, 2011 | 164 | 2011 |
Circadian clock component REV-ERBα controls homeostatic regulation of pulmonary inflammation M Pariollaud, JE Gibbs, TW Hopwood, S Brown, N Begley, R Vonslow, ... The Journal of clinical investigation 128 (6), 2281-2296, 2018 | 155 | 2018 |
Ruthenium-catalyzed polycyclization reactions WJ Zuercher, M Scholl, RH Grubbs The Journal of Organic Chemistry 63 (13), 4291-4298, 1998 | 151 | 1998 |
Progress towards a public chemogenomic set for protein kinases and a call for contributions DH Drewry, CI Wells, DM Andrews, R Angell, H Al-Ali, AD Axtman, ... PloS one 12 (8), e0181585, 2017 | 149 | 2017 |
X-ray crystal structures of the estrogen-related receptor-γ ligand binding domain in three functional states reveal the molecular basis of small molecule regulation L Wang, WJ Zuercher, TG Consler, MH Lambert, AB Miller, ... Journal of Biological Chemistry 281 (49), 37773-37781, 2006 | 147 | 2006 |
GSK4112, a small molecule chemical probe for the cell biology of the nuclear heme receptor Rev-erbα D Grant, L Yin, JL Collins, DJ Parks, LA Orband-Miller, GB Wisely, S Joshi, ... ACS chemical biology 5 (10), 925-932, 2010 | 145 | 2010 |
Crystal structure of the PXR–T1317 complex provides a scaffold to examine the potential for receptor antagonism Y Xue, E Chao, WJ Zuercher, TM Willson, JL Collins, MR Redinbo Bioorganic & medicinal chemistry 15 (5), 2156-2166, 2007 | 140 | 2007 |
Seeding collaborations to advance kinase science with the GSK Published Kinase Inhibitor Set (PKIS) D H Drewry, T M Willson, W J Zuercher Current topics in medicinal chemistry 14 (3), 340-342, 2014 | 124 | 2014 |
Identification and structure− activity relationship of phenolic acyl hydrazones as selective agonists for the estrogen-related orphan nuclear receptors ERRβ and ERRγ WJ Zuercher, S Gaillard, LA Orband-Miller, EYH Chao, BG Shearer, ... Journal of medicinal chemistry 48 (9), 3107-3109, 2005 | 124 | 2005 |
Structure-guided synthesis of tamoxifen analogs with improved selectivity for the orphan ERRγ EYH Chao, JL Collins, S Gaillard, AB Miller, L Wang, LA Orband-Miller, ... Bioorganic & medicinal chemistry letters 16 (4), 821-824, 2006 | 105 | 2006 |
Discovery of tertiary sulfonamides as potent liver X receptor antagonists WJ Zuercher, RG Buckholz, N Campobasso, JL Collins, CM Galardi, ... Journal of medicinal chemistry 53 (8), 3412-3416, 2010 | 101 | 2010 |
Small molecule agonists of the orphan nuclear receptors steroidogenic factor-1 (SF-1, NR5A1) and liver receptor homologue-1 (LRH-1, NR5A2) RJ Whitby, J Stec, RD Blind, S Dixon, LM Leesnitzer, LA Orband-Miller, ... Journal of medicinal chemistry 54 (7), 2266-2281, 2011 | 93 | 2011 |
Donated chemical probes for open science S Müller, S Ackloo, CH Arrowsmith, M Bauser, JL Baryza, J Blagg, ... Elife 7, e34311, 2018 | 92 | 2018 |