CpG island methylator phenotype in colorectal cancer M Toyota, N Ahuja, M Ohe-Toyota, JG Herman, SB Baylin, JPJ Issa Proceedings of the National Academy of Sciences 96 (15), 8681-8686, 1999 | 3153 | 1999 |
Alterations in DNA methylation: a fundamental aspect of neoplasia SB Baylln, JG Herman, JR Graff, PM Vertino, JP Issa Advances in cancer research 72, 141-196, 1997 | 2608 | 1997 |
Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma JG Herman, A Umar, K Polyak, JR Graff, N Ahuja, JPJ Issa, S Markowitz, ... Proceedings of the National Academy of Sciences 95 (12), 6870-6875, 1998 | 2451 | 1998 |
Inactivation of the CDKN2/p16/MTS1 Gene Is Frequently Associated with Aberrant DNA Methylation in All Common Human Cancers JG Herman, A Merlo, LI Mao, RG Lapidus, JPJ Issa, NE Davidson, ... Cancer research 55 (20), 4525-4530, 1995 | 1972 | 1995 |
Decitabine improves patient outcomes in myelodysplastic syndromes: results of a phase III randomized study H Kantarjian, JPJ Issa, CS Rosenfeld, JM Bennett, M Albitar, J DiPersio, ... Cancer: Interdisciplinary International Journal of the American Cancer …, 2006 | 1933 | 2006 |
Methylation of the oestrogen receptor CpG island links ageing and neoplasia in human colon JPJ Issa, YL Ottaviano, P Celano, SR Hamilton, NE Davidson, SB Baylin Nature genetics 7 (4), 536-540, 1994 | 1460 | 1994 |
CpG island methylator phenotype in cancer JP Issa Nature Reviews Cancer 4 (12), 988-993, 2004 | 1403 | 2004 |
Dnmt3a is essential for hematopoietic stem cell differentiation GA Challen, D Sun, M Jeong, M Luo, J Jelinek, JS Berg, C Bock, ... Nature genetics 44 (1), 23-31, 2012 | 1291 | 2012 |
Targeting the cancer epigenome for therapy PA Jones, JPJ Issa, S Baylin Nature Reviews Genetics 17 (10), 630-641, 2016 | 1178 | 2016 |
A simple method for estimating global DNA methylation using bisulfite PCR of repetitive DNA elements AS Yang, MRH Estécio, K Doshi, Y Kondo, EH Tajara, JPJ Issa Nucleic acids research 32 (3), e38-e38, 2004 | 1171 | 2004 |
Phase 1 study of low-dose prolonged exposure schedules of the hypomethylating agent 5-aza-2′-deoxycytidine (decitabine) in hematopoietic malignancies JPJ Issa, G Garcia-Manero, FJ Giles, R Mannari, D Thomas, S Faderl, ... Blood 103 (5), 1635-1640, 2004 | 1041 | 2004 |
Results of a randomized study of 3 schedules of low-dose decitabine in higher-risk myelodysplastic syndrome and chronic myelomonocytic leukemia H Kantarjian, Y Oki, G Garcia-Manero, X Huang, S O'Brien, J Cortes, ... Blood 109 (1), 52-57, 2007 | 987 | 2007 |
Aging and DNA methylation in colorectal mucosa and cancer N Ahuja, Q Li, AL Mohan, SB Baylin, JPJ Issa Cancer research 58 (23), 5489-5494, 1998 | 788 | 1998 |
Accelerated age-related CpG island methylation in ulcerative colitis JPJ Issa, N Ahuja, M Toyota, MP Bronner, TA Brentnall Cancer research 61 (9), 3573-3577, 2001 | 769 | 2001 |
DNA methylation aging clocks: challenges and recommendations CG Bell, R Lowe, PD Adams, AA Baccarelli, S Beck, JT Bell, ... Genome biology 20, 1-24, 2019 | 760 | 2019 |
Phase II Pilot Study of Vemurafenib in Patients With Metastatic BRAF-Mutated Colorectal Cancer S Kopetz, J Desai, E Chan, JR Hecht, PJ O'Dwyer, D Maru, V Morris, ... Journal of clinical oncology 33 (34), 4032-4038, 2015 | 758 | 2015 |
Gene silencing in cancer by histone H3 lysine 27 trimethylation independent of promoter DNA methylation Y Kondo, L Shen, AS Cheng, S Ahmed, Y Boumber, C Charo, T Yamochi, ... Nature genetics 40 (6), 741-750, 2008 | 713 | 2008 |
Integrated genetic and epigenetic analysis identifies three different subclasses of colon cancer L Shen, M Toyota, Y Kondo, E Lin, L Zhang, Y Guo, NS Hernandez, ... Proceedings of the National Academy of Sciences 104 (47), 18654-18659, 2007 | 704 | 2007 |
Transient low doses of DNA-demethylating agents exert durable antitumor effects on hematological and epithelial tumor cells HC Tsai, H Li, L Van Neste, Y Cai, C Robert, FV Rassool, JJ Shin, ... Cancer cell 21 (3), 430-446, 2012 | 702 | 2012 |
Inactivation of the DNA Repair Gene O6-Methylguanine-DNA Methyltransferase by Promoter Hypermethylation Is Associated with G to A Mutations in K-ras in … M Esteller, M Toyota, M Sanchez-Cespedes, G Capella, MA Peinado, ... Cancer research 60 (9), 2368-2371, 2000 | 682 | 2000 |