Marek Orzechowski
Marek Orzechowski
Broad Institute
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A Next Generation Connectivity Map: L1000 Platform and the First 1,000,000 Profiles
Cell 171 (6), 1437–1452, 2017
Flexible fitting of high-resolution x-ray structures into cryoelectron microscopy maps using biased molecular dynamics simulations
M Orzechowski, F Tama
Biophysical journal 95 (12), 5692-5705, 2008
Gestalt-binding of tropomyosin on actin during thin filament activation
W Lehman, M Orzechowski, XE Li, S Fischer, S Raunser
Journal of muscle research and cell motility 34 (3), 155-163, 2013
Three-dimensional organization of troponin on cardiac muscle thin filaments in the relaxed state
S Yang, L Barbu-Tudoran, M Orzechowski, R Craig, J Trinick, H White, ...
Biophysical journal 106 (4), 855-864, 2014
An atomic model of the tropomyosin cable on F-actin
M Orzechowski, XE Li, S Fischer, W Lehman
Biophysical journal 107 (3), 694-699, 2014
Biased coarse-grained molecular dynamics simulation approach for flexible fitting of X-ray structure into cryo electron microscopy maps
I Grubisic, MN Shokhirev, M Orzechowski, O Miyashita, F Tama
Journal of structural biology 169 (1), 95-105, 2010
Energy landscapes reveal the myopathic effects of tropomyosin mutations
M Orzechowski, S Fischer, JR Moore, W Lehman, GP Farman
Archives of Biochemistry and Biophysics 564, 89-99, 2014
Structure and flexibility of the tropomyosin overlap junction
XE Li, M Orzechowski, W Lehman, S Fischer
Biochemical and biophysical research communications 446 (1), 304-308, 2014
SARS‐CoV‐2 antibody persistence in COVID‐19 convalescent plasma donors: Dependency on assay format and applicability to serosurveillance
C Di Germanio, G Simmons, K Kelly, R Martinelli, O Darst, M Azimpouran, ...
Transfusion 61 (9), 2677-2687, 2021
Tropomyosin movement on F-actin during muscle activation explained by energy landscapes
M Orzechowski, JR Moore, S Fischer, W Lehman
Archives of biochemistry and biophysics 545, 63-68, 2014
Mechanical unfolding of the beet western yellow virus− 1 frameshift signal
KH White, M Orzechowski, D Fourmy, K Visscher
Journal of the American Chemical Society 133 (25), 9775-9782, 2011
Application of steered molecular dynamics (SMD) to study DNA–drug complexes and probing helical propensity of amino acids
M Orzechowski, P Cieplak
Journal Of Physics: Condensed Matter 17 (18), S1627, 2005
Electrostatic interaction map reveals a new binding position for tropomyosin on F-actin
MJ Rynkiewicz, V Schott, M Orzechowski, W Lehman, S Fischer
Journal of muscle research and cell motility 36 (6), 525-533, 2015
The structural dynamics of α-tropomyosin on F-actin shape the overlap complex between adjacent tropomyosin molecules
W Lehman, XE Li, M Orzechowski, S Fischer
Archives of biochemistry and biophysics 552, 68-73, 2014
HCM and DCM cardiomyopathy-linked α-tropomyosin mutations influence off-state stability and crossbridge interaction on thin filaments
GP Farman, MJ Rynkiewicz, M Orzechowski, W Lehman, JR Moore
Archives of biochemistry and biophysics 647, 84-92, 2018
Dynamics of Water Filaments in Disordered Environments
M Orzechowski, M Meuwly
The Journal of Physical Chemistry B 114 (38), 12203-12212, 2010
Theoretical calculation of the coiled‐coil stability in water in the context of its possible use as a molecular rack
M Orzechowski, P Cieplak, L Piela
Journal of computational chemistry 23 (1), 106-110, 2002
Large-Scale Chemical-Genetic Strategy Enables the Design of Antimicrobial Combination Chemotherapy in Mycobacteria
EO Johnson, E Office, T Kawate, M Orzechowski, DT Hung
ACS infectious diseases 6 (1), 56-63, 2019
Influence of actin mutation on the energy landscape of actin-tropomyosin filaments
M Orzechowski, S Fischer, W Lehman
Biophysical Journal 104 (2), 480a, 2013
Does Tropomyosin Slide or Roll over F-Actin during Regulatory Transitions?
M Rynkiewicz, V Schott, M Orzechowski, S Fischer, W Lehman
Biophysical Journal 110 (3), 524a, 2016
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