Understanding the mechanism of IL-1β secretion G Lopez-Castejon, D Brough Cytokine & growth factor reviews 22 (4), 189-195, 2011 | 1813 | 2011 |
The NLRP3 inflammasome is released as a particulate danger signal that amplifies the inflammatory response A Baroja-Mazo, F Martín-Sánchez, AI Gomez, CM Martínez, ... Nature immunology 15 (8), 738-748, 2014 | 901 | 2014 |
Consensus guidelines for the detection of immunogenic cell death O Kepp, L Senovilla, I Vitale, E Vacchelli, S Adjemian, P Agostinis, ... Oncoimmunology 3 (9), e955691, 2014 | 877 | 2014 |
Fenamate NSAIDs inhibit the NLRP3 inflammasome and protect against Alzheimer’s disease in rodent models MJD Daniels, J Rivers-Auty, T Schilling, NG Spencer, W Watremez, ... Nature communications 7 (1), 12504, 2016 | 446 | 2016 |
Molecular and translational classifications of DAMPs in immunogenic cell death AD Garg, L Galluzzi, L Apetoh, T Baert, RB Birge, JM Bravo-San Pedro, ... Frontiers in immunology 6, 588, 2015 | 417 | 2015 |
Brain injury induces specific changes in the caecal microbiota of mice via altered autonomic activity and mucoprotein production A Houlden, M Goldrick, D Brough, ES Vizi, N Lénárt, B Martinecz, ... Brain, behavior, and immunity 57, 10-20, 2016 | 370 | 2016 |
Caspase-1-dependent processing of pro-interleukin-1β is cytosolic and precedes cell death D Brough, NJ Rothwell Journal of cell science 120 (5), 772-781, 2007 | 362 | 2007 |
Caspase-1: is IL-1 just the tip of the ICEberg? A Denes, G Lopez-Castejon, D Brough Cell death & disease 3 (7), e338-e338, 2012 | 319 | 2012 |
Inflammasome-dependent IL-1β release depends upon membrane permeabilisation F Martín-Sánchez, C Diamond, M Zeitler, AI Gomez, A Baroja-Mazo, ... Cell Death & Differentiation 23 (7), 1219-1231, 2016 | 304 | 2016 |
AIM2 and NLRC4 inflammasomes contribute with ASC to acute brain injury independently of NLRP3 A Denes, G Coutts, N Lénárt, SM Cruickshank, P Pelegrin, J Skinner, ... Proceedings of the National Academy of Sciences 112 (13), 4050-4055, 2015 | 286 | 2015 |
Ca2+ stores and Ca2+ entry differentially contribute to the release of IL-1β and IL-1α from murine macrophages D Brough, RA Le Feuvre, RD Wheeler, N Solovyova, S Hilfiker, ... The Journal of Immunology 170 (6), 3029-3036, 2003 | 237 | 2003 |
Priming of macrophages with lipopolysaccharide potentiates P2X7-mediated cell death via a caspase-1-dependent mechanism, independently of cytokine production RA Le Feuvre, D Brough, Y Iwakura, K Takeda, NJ Rothwell Journal of Biological Chemistry 277 (5), 3210-3218, 2002 | 235 | 2002 |
Deubiquitinases regulate the activity of caspase-1 and interleukin-1β secretion via assembly of the inflammasome G Lopez-Castejon, NM Luheshi, V Compan, S High, RC Whitehead, ... Journal of Biological Chemistry 288 (4), 2721-2733, 2013 | 219 | 2013 |
NLRP3-inflammasome activating DAMPs stimulate an inflammatory response in glia in the absence of priming which contributes to brain inflammation after injury CD Savage, G Lopez-Castejon, A Denes, D Brough Frontiers in immunology 3, 288, 2012 | 217 | 2012 |
Extracellular ATP and P2X7 receptors in neurodegeneration R Le Feuvre, D Brough, N Rothwell European journal of pharmacology 447 (2-3), 261-269, 2002 | 202 | 2002 |
Interleukin-1α expression precedes IL-1β after ischemic brain injury and is localised to areas of focal neuronal loss and penumbral tissues NM Luheshi, KJ Kovács, G Lopez-Castejon, D Brough, A Denes Journal of neuroinflammation 8, 1-5, 2011 | 191 | 2011 |
Chloride regulates dynamic NLRP3-dependent ASC oligomerization and inflammasome priming JP Green, S Yu, F Martín-Sánchez, P Pelegrin, G Lopez-Castejon, ... Proceedings of the National Academy of Sciences 115 (40), E9371-E9380, 2018 | 186 | 2018 |
Inflammasomes link vascular disease with neuroinflammation and brain disorders N Lénárt, D Brough, Á Dénes Journal of Cerebral Blood Flow & Metabolism 36 (10), 1668-1685, 2016 | 182 | 2016 |
Release of interleukin-1α or interleukin-1β depends on mechanism of cell death H England, HR Summersgill, ME Edye, NJ Rothwell, D Brough Journal of Biological Chemistry 289 (23), 15942-15950, 2014 | 180 | 2014 |
Microglia and macrophages differentially modulate cell death after brain injury caused by oxygen‐glucose deprivation in organotypic brain slices S Girard, D Brough, G Lopez‐Castejon, J Giles, NJ Rothwell, SM Allan Glia 61 (5), 813-824, 2013 | 180 | 2013 |