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Samuel Peña Díaz
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Small molecule inhibits α-synuclein aggregation, disrupts amyloid fibrils, and prevents degeneration of dopaminergic neurons
J Pujols, S Peña-Díaz, DF Lázaro, F Peccati, F Pinheiro, D González, ...
Proceedings of the National Academy of Sciences 115 (41), 10481-10486, 2018
1922018
DisProt in 2022: improved quality and accessibility of protein intrinsic disorder annotation
F Quaglia, B Mészáros, E Salladini, A Hatos, R Pancsa, LB Chemes, ...
Nucleic acids research 50 (D1), D480-D487, 2022
1252022
High-throughput screening methodology to identify alpha-synuclein aggregation inhibitors
J Pujols, S Peña-Díaz, M Conde-Giménez, F Pinheiro, S Navarro, ...
International journal of molecular sciences 18 (3), 478, 2017
772017
α-Helical peptidic scaffolds to target α-synuclein toxic species with nanomolar affinity
J Santos, P Gracia, S Navarro, S Peña-Díaz, J Pujols, N Cremades, ...
Nature communications 12 (1), 3752, 2021
512021
Chemical chaperones as novel drugs for Parkinson’s disease
J Pujols, S Peña-Díaz, I Pallarès, S Ventura
Trends in molecular medicine 26 (4), 408-421, 2020
482020
ZPD-2, a small compound that inhibits α-synuclein amyloid aggregation and its seeded polymerization
S Peña-Díaz, J Pujols, M Conde-Giménez, A Èarija, E Dalfo, J García, ...
Frontiers in molecular neuroscience 12, 306, 2019
342019
One ring is sufficient to inhibit α-synuclein aggregation
S Peña-Díaz, S Ventura
Neural Regeneration Research 17 (3), 508-511, 2022
252022
Rational design of small molecules able to inhibit α-synuclein amyloid aggregation for the treatment of Parkinson’s disease
S Vittorio, I Adornato, R Gitto, S Peña-Díaz, S Ventura, L De Luca
Journal of Enzyme Inhibition and Medicinal Chemistry 35 (1), 1727-1735, 2020
202020
Inhibition of α-synuclein aggregation and mature fibril disassembling with a minimalistic compound, ZPDm
S Peña-Díaz, J Pujols, F Pinheiro, J Santos, I Pallarés, S Navarro, ...
Frontiers in Bioengineering and Biotechnology 8, 588947, 2020
162020
Development of small molecules targeting α-synuclein aggregation: a promising strategy to treat Parkinson’s disease
S Peña-Díaz, J García-Pardo, S Ventura
Pharmaceutics 15 (3), 839, 2023
142023
AGGRESCAN3D: toward the prediction of the aggregation propensities of protein structures
J Pujols, S Peña-Díaz, S Ventura
Computational Drug Discovery and Design, 427-443, 2018
142018
Design, synthesis and structure-activity evaluation of novel 2-pyridone-based inhibitors of α-synuclein aggregation with potentially improved BBB permeability
A Mahía, S Peña-Díaz, S Navarro, JJ Galano-Frutos, I Pallarés, J Pujols, ...
Bioorganic Chemistry 117, 105472, 2021
122021
Small molecules to prevent the neurodegeneration caused by α-synuclein aggregation
S Pena-Diaz, J Pujols, S Ventura
Neural Regeneration Research 15 (12), 2260-2261, 2020
112020
Discovery of neuroprotective agents based on a 5-(4-Pyridinyl)-1, 2, 4-triazole scaffold
R Gitto, S Vittorio, F Bucolo, S Peña-Díaz, R Siracusa, S Cuzzocrea, ...
ACS Chemical Neuroscience 13 (5), 581-586, 2022
92022
The small aromatic compound SynuClean-D inhibits the aggregation and seeded polymerization of multiple α-synuclein strains
S Peña-Díaz, J Pujols, E Vasili, F Pinheiro, J Santos, ...
Journal of Biological Chemistry 298 (5), 2022
72022
Ligand-based discovery of a small molecule as inhibitor of α-synuclein amyloid formation
L De Luca, S Vittorio, S Peña-Díaz, G Pitasi, M Fornt-Suñé, F Bucolo, ...
International journal of molecular sciences 23 (23), 14844, 2022
52022
Functional Amyloids: The Biomaterials of Tomorrow?
S Peña‐Díaz, WP Olsen, H Wang, DE Otzen
Advanced Materials, 2312823, 2024
22024
Mining and engineering activity in catalytic amyloids
S Peña-Díaz, P Ferreira, MJ Ramos, DE Otzen
Academic Press, 2024
2024
479 Implications for brainstem recovery from studies in primates after sensory loss from arm
EF Trakhtenberg, B Pavan, JJ Pérez-Moreno, M Miyajima, H Tabata, ...
NEURAL REGENERATION RESEARCH 19 (3), 465, 2024
2024
Small molecules to target tau amyloid aggregation
Z Manglano-Artuñedo, S Peña-Díaz, S Ventura
Neural Regeneration Research, 2023
2023
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Articles 1–20