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Richard P. Loach
Richard P. Loach
Principal Scientist, Pfizer Medicine Design
Zweryfikowany adres z pfizer.com
Tytuł
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Cytowane przez
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C7-Derivatization of C3-Alkylindoles Including Tryptophans and Tryptamines
RP Loach, OS Fenton, K Amaike, DS Siegel, E Ozkal, M Movassaghi
The Journal of organic chemistry 79 (22), 11254-11263, 2014
1142014
Employing Photoredox Catalysis for DNA‐Encoded Chemistry: Decarboxylative Alkylation of α‐Amino Acids
DK Kölmel, RP Loach, T Knauber, ME Flanagan
ChemMedChem 13 (20), 2159-2165, 2018
972018
Employing Photoredox Catalysis for DNA‐Encoded Chemistry: Decarboxylative Alkylation of α‐Amino Acids
DK Kölmel, RP Loach, T Knauber, ME Flanagan
ChemMedChem 13 (20), 2159-2165, 2018
972018
General, regiodefined access to alpha-substituted butenolides through metal-halogen exchange of 3-bromo-2-silyloxyfurans. Efficient synthesis of an anti-inflammatory gorgonian …
J Boukouvalas, RP Loach
The Journal of organic chemistry 73 (20), 8109-8112, 2008
902008
On-DNA Decarboxylative Arylation: The Merger of Photoredox with Nickel Catalysis in Water
DK Kölmel, J Meng, MH Tsai, J Que, RP Loach, T Knauber, J Wan, ...
ACS Combinatorial Science, 2019
792019
Concise Total Synthesis of (+)-Asperazine, (+)-Pestalazine A, and (+)-iso-Pestalazine A. Structure Revision of (+)-Pestalazine A
RP Loach, OS Fenton, M Movassaghi
Journal of the American Chemical Society 138 (3), 1057-1064, 2016
612016
Unified route to asymmetrically substituted butenolide, maleic anhydride, and maleimide constituents of Antrodia camphorata
J Boukouvalas, V Albert, RP Loach, R Lafleur-Lambert
Tetrahedron 68 (47), 9592-9597, 2012
282012
Oxidative rearrangement of 2-furylcarbamates with dimethyldioxirane: a high-yielding preparation of 5-hydroxypyrrol-2 (5H)-ones
J Boukouvalas, RP Loach, E Ouellet
Tetrahedron letters 52 (39), 5047-5050, 2011
252011
Concise total synthesis of (+)-asperazine A and (+)-pestalazine B
BM Nelson, RP Loach, S Schiesser, M Movassaghi
Organic & biomolecular chemistry 16 (2), 202-207, 2018
192018
Concise Total Synthesis of (−)-Auxofuran by a Click Diels–Alder Strategy
J Boukouvalas, RP Loach
Organic letters 15 (18), 4912-4914, 2013
162013
Direct C7 Functionalization of Tryptophan. Synthesis of Methyl (S)‐2‐((tert‐Butoxycarbonyl)amino)‐3‐(7‐(4,4,5,5‐tetramethyl‐1,3,2‐dioxaborolan‐2‐yl)‐1H‐indol …
K Amaike, RP Loach, M Movassaghi* 2
Organic Syntheses 92, 373-385, 2003
14*2003
Aminolactone Chiral Modifiers for Heterogeneous Asymmetric Hydrogenation: Corrected Structure of Pantoyl-Naphthylethylamine, in-Situ Hydrogenolysis, and Scanning Tunneling …
G Goubert, V Demers-Carpentier, RP Loach, R Lafleur-Lambert, ...
ACS Catalysis 3 (12), 2677-2683, 2013
132013
α-Chiral amines via thermally promoted deaminative addition of alkylpyridinium salts to sulfinimines
KM Baker, A Tallon, RP Loach, OP Bercher, MA Perry, MP Watson
Organic letters 23 (20), 7735-7739, 2021
112021
Early Clinical Development of Lufotrelvir as a Potential Therapy for COVID-19
C Allais, D Bernhardson, AR Brown, GM Chinigo, JN Desrosiers, ...
Organic Process Research & Development, 2023
102023
Dimethyldioxirane oxidation of 2-silyloxypyrroles: An efficient regiocontrolled synthesis of 5-hydroxy-3-pyrrolin-2-ones
J Boukouvalas, Y Xiao, YX Cheng, RP Loach
Synlett 2007 (20), 3198-3200, 2007
62007
Expedient Assembly of Bioactive Maleic Anhydrides Using Click Diels–Alder Chemistry
J Boukouvalas, C Thibault, RP Loach
Synlett 25 (15), 2139-2142, 2014
32014
Front Cover: Employing Photoredox Catalysis for DNA‐Encoded Chemistry: Decarboxylative Alkylation of α‐Amino Acids (ChemMedChem 20/2018)
DK Kölmel, RP Loach, T Knauber, ME Flanagan
ChemMedChem 13 (20), 2132-2132, 2018
12018
Total synthesis of gamma-hydroxybutenolide-containing acetogenins
R Muddala, R Loach, J Boukouvalas
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 251, 2016
2016
C7-derivatization of tryptophans and tryptamines for the synthesis of complex alkaloids
R Loach, O Fenton, K Amaike, D Siegel, E Ozkal, M Movassaghi
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 250, 2015
2015
C7-Derivatization of Tryptophans and Tryptamines for the Synthesis of Complex Alkaloids
MM Richard P. Loach, Owen S. Fenton, Kazuma Amaike, Dustin S. Siegel, Erhan ...
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 245, 2015
2015
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