|Neuroinflammation: the devil is in the details|
DJ DiSabato, N Quan, JP Godbout
Journal of neurochemistry 139, 136-153, 2016
|Exaggerated neuroinflammation and sickness behavior in aged mice after activation of the peripheral innate immune system|
JP Godbout, J Chen, J Abraham, AF Richwine, BM Berg, KW Kelley, ...
The FASEB journal 19 (10), 1329-1331, 2005
|Microglia of the aged brain: primed to be activated and resistant to regulation|
DM Norden, JP Godbout
Neuropathology and applied neurobiology 39 (1), 19-34, 2013
|Minocycline attenuates lipopolysaccharide (LPS)-induced neuroinflammation, sickness behavior, and anhedonia|
CJ Henry, Y Huang, A Wynne, M Hanke, J Himler, MT Bailey, JF Sheridan, ...
Journal of neuroinflammation 5 (1), 1-14, 2008
|β-Adrenergic receptor antagonism prevents anxiety-like behavior and microglial reactivity induced by repeated social defeat|
ES Wohleb, ML Hanke, AW Corona, ND Powell, MS La'Tonia, MT Bailey, ...
Journal of Neuroscience 31 (17), 6277-6288, 2011
|Peripheral lipopolysaccharide (LPS) challenge promotes microglial hyperactivity in aged mice that is associated with exaggerated induction of both pro-inflammatory IL-1β and …|
CJ Henry, Y Huang, AM Wynne, JP Godbout
Brain, behavior, and immunity 23 (3), 309-317, 2009
|Microglia induce motor neuron death via the classical NF-κB pathway in amyotrophic lateral sclerosis|
AE Frakes, L Ferraiuolo, AM Haidet-Phillips, L Schmelzer, L Braun, ...
Neuron 81 (5), 1009-1023, 2014
|Stress-induced immune dysregulation: implications for wound healing, infectious disease and cancer|
JP Godbout, R Glaser
Journal of Neuroimmune Pharmacology 1, 421-427, 2006
|Stress-induced recruitment of bone marrow-derived monocytes to the brain promotes anxiety-like behavior|
ES Wohleb, ND Powell, JP Godbout, JF Sheridan
Journal of Neuroscience 33 (34), 13820-13833, 2013
|Neuroinflammation and disruption in working memory in aged mice after acute stimulation of the peripheral innate immune system|
J Chen, JB Buchanan, NL Sparkman, JP Godbout, GG Freund, ...
Brain, behavior, and immunity 22 (3), 301-311, 2008
|Sequential activation of microglia and astrocyte cytokine expression precedes increased Iba‐1 or GFAP immunoreactivity following systemic immune challenge|
DM Norden, PJ Trojanowski, E Villanueva, E Navarro, JP Godbout
Glia 64 (2), 300-316, 2016
|Monocyte trafficking to the brain with stress and inflammation: a novel axis of immune-to-brain communication that influences mood and behavior|
ES Wohleb, DB McKim, JF Sheridan, JP Godbout
Frontiers in neuroscience 8, 447, 2015
|Microglial priming and enhanced reactivity to secondary insult in aging, and traumatic CNS injury, and neurodegenerative disease|
DM Norden, MM Muccigrosso, JP Godbout
Neuropharmacology 96, 29-41, 2015
|Aging exacerbates depressive-like behavior in mice in response to activation of the peripheral innate immune system|
JP Godbout, M Moreau, J Lestage, J Chen, NL Sparkman, JO Connor, ...
Neuropsychopharmacology 33 (10), 2341-2351, 2008
|Peripheral innate immune challenge exaggerated microglia activation, increased the number of inflammatory CNS macrophages, and prolonged social withdrawal in socially defeated mice|
ES Wohleb, AM Fenn, AM Pacenta, ND Powell, JF Sheridan, JP Godbout
Psychoneuroendocrinology 37 (9), 1491-1505, 2012
|Microglia priming with aging and stress|
A Niraula, JF Sheridan, JP Godbout
Neuropsychopharmacology 42 (1), 318-333, 2017
|Re-establishment of anxiety in stress-sensitized mice is caused by monocyte trafficking from the spleen to the brain|
ES Wohleb, DB McKim, DT Shea, ND Powell, AJ Tarr, JF Sheridan, ...
Biological psychiatry 75 (12), 970-981, 2014
|Exaggerated sickness behavior and brain proinflammatory cytokine expression in aged mice in response to intracerebroventricular lipopolysaccharide|
Y Huang, CJ Henry, R Dantzer, RW Johnson, JP Godbout
Neurobiology of aging 29 (11), 1744-1753, 2008
|Microglial recruitment of IL-1β-producing monocytes to brain endothelium causes stress-induced anxiety|
DB McKim, MD Weber, A Niraula, CM Sawicki, X Liu, BL Jarrett, ...
Molecular psychiatry 23 (6), 1421-1431, 2018
|Immune activation promotes depression 1 month after diffuse brain injury: a role for primed microglia|
AM Fenn, JC Gensel, Y Huang, PG Popovich, J Lifshitz, JP Godbout
Biological psychiatry 76 (7), 575-584, 2014