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Aditya Sudheer Vaidya
Aditya Sudheer Vaidya
Inne imiona/nazwiskaAditya S.Vaidya
Senior Scientist, Chemical Biology Innovation
Zweryfikowany adres z milliporesigma.com
Tytuł
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Dynamic control of plant water use using designed ABA receptor agonists
AS Vaidya, JDM Helander, FC Peterson, D Elzinga, W Dejonghe, ...
Science 366 (6464), eaaw8848, 2019
1182019
A rationally designed agonist defines subfamily IIIA abscisic acid receptors as critical targets for manipulating transpiration
AS Vaidya, FC Peterson, D Yarmolinsky, E Merilo, I Verstraeten, SY Park, ...
ACS Chemical Biology 12 (11), 2842-2848, 2017
672017
Chemical manipulation of plant water use
JDM Helander, AS Vaidya, SR Cutler
Bioorganic & Medicinal Chemistry 24 (3), 493-500, 2016
622016
A chimeric SERM–histone deacetylase inhibitor approach to breast cancer therapy
HK Patel, MI Siklos, H Abdelkarim, EL Mendonca, A Vaidya, PA Petukhov, ...
ChemMedChem 9 (3), 602-613, 2014
252014
Novel histone deacetylase 8 ligands without a zinc chelating group: Exploring an ‘upside-down’binding pose
AS Vaidya, R Neelarapu, A Madriaga, H Bai, E Mendonca, H Abdelkarim, ...
Bioorganic & medicinal chemistry letters 22 (21), 6621-6627, 2012
242012
Defining and exploiting hypersensitivity hotspots to facilitate abscisic acid agonist optimization
D Elzinga, E Sternburg, D Sabbadin, M Bartsch, SY Park, A Vaidya, ...
ACS chemical biology 14 (3), 332-336, 2019
232019
Design, synthesis, modeling, biological evaluation and photoaffinity labeling studies of novel series of photoreactive benzamide probes for histone deacetylase 2
AS Vaidya, B Karumudi, E Mendonca, A Madriaga, H Abdelkarim, ...
Bioorganic & medicinal chemistry letters 22 (15), 5025-5030, 2012
212012
Click-to-lead design of a picomolar ABA receptor antagonist with potent activity in vivo
AS Vaidya, FC Peterson, J Eckhardt, Z Xing, SY Park, W Dejonghe, ...
Proceedings of the National Academy of Sciences 118 (38), e2108281118, 2021
162021
Design, Synthesis, Molecular Modeling, and Biological Evaluation of Novel Amine‐based Histone Deacetylase Inhibitors
H Abdelkarim, R Neelarapu, A Madriaga, AS Vaidya, I Kastrati, ...
ChemMedChem 12 (24), 2030-2043, 2017
102017
Selective control of parasitic nematodes using bioactivated nematicides
AR Burns, RJ Baker, M Kitner, J Knox, B Cooke, JR Volpatti, AS Vaidya, ...
Nature, 1-8, 2023
52023
Chemical approaches for improving plant water use
AS Vaidya, SR Cutler
Abscisic Acid: Methods and Protocols, 221-230, 2022
42022
A luciferase reporter assay to identify chemical activators of ABA signaling
I García-Maquilón, PL Rodriguez, AS Vaidya, J Lozano-Juste
Plant Chemical Genomics: Methods and Protocols, 113-121, 2021
42021
Egg-laying and locomotory screens with C. elegans yield a nematode-selective small molecule stimulator of neurotransmitter release
S Harrington, JJ Knox, AR Burns, KL Choo, A Au, M Kitner, C Haeberli, ...
Communications Biology 5 (1), 865, 2022
32022
PYL10 bound to the ABA pan-antagonist 4a
FC Peterson, AS Vaidya, BF Volkman, SR Cutler
(No Title), 2021
22021
Synthesis and characterization of abscisic acid receptor modulators
AS Vaidya, SY Park, Z Xing, SR Cutler
Methods in Enzymology 671, 435-470, 2022
12022
In Planta Labeling Using a Clickable ER-Disrupting Probe Suggests a Role for Oleosins in Arabidopsis Seedling ER Integrity
W Dejonghe, AS Vaidya, SE Alfred, SR Cutler
ACS Chemical Biology 16 (11), 2151-2157, 2021
12021
Unusually potent ABA receptor pan-antagonists
SR Cutler, A Vaidya
US Patent 11,641,857, 2023
2023
Nementin is a Nematode-Selective Small Molecule Agonist of Neurotransmitter Release
S Harrington, JJ Knox, AR Burns, KL Choo, A Au, M Kitner, C Haeberli, ...
bioRxiv, 2022.03. 12.484074, 2022
2022
INAUGURAL ARTICLE by a Recently Elected Academy Member: Click-to-lead design of a picomolar ABA receptor antagonist with potent activity in vivo
AS Vaidya, FC Peterson, J Eckhardt, Z Xing, SY Park, W Dejonghe, ...
Proceedings of the National Academy of Sciences of the United States of …, 2021
2021
Overpowered aba receptor agonists
SR Cutler, A Vaidya, J Helander
US Patent App. 17/135,194, 2021
2021
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