| Structural basis for the inhibition of the essential Plasmodium falciparum M1 neutral aminopeptidase S McGowan, CJ Porter, J Lowther, CM Stack, SJ Golding, ... Proceedings of the National Academy of Sciences 106 (8), 2537-2542, 2009 | 176 | 2009 |
| Structural basis for the inhibition of the essential Plasmodium falciparum M1 neutral aminopeptidase S McGowan, CJ Porter, J Lowther, CM Stack, SJ Golding, ... Proceedings of the National Academy of Sciences 106 (8), 2537-2542, 2009 | 176 | 2009 |
| Characterization of the Plasmodium falciparum M17 leucyl aminopeptidase: a protease involved in amino acid regulation with potential for antimalarial drug development CM Stack, J Lowther, E Cunningham, S Donnelly, DL Gardiner, ... Journal of Biological Chemistry 282 (3), 2069-2080, 2007 | 158 | 2007 |
| Plasmodium falciparum neutral aminopeptidases: new targets for anti-malarials TS Skinner-Adams, CM Stack, KR Trenholme, CL Brown, J Grembecka, ... Trends in biochemical sciences 35 (1), 53-61, 2010 | 156 | 2010 |
| Proteomics and phylogenetic analysis of the cathepsin L protease family of the helminth pathogen Fasciola hepatica: expansion of a repertoire of virulence-associated factors MW Robinson, JF Tort, J Lowther, SM Donnelly, E Wong, W Xu, CM Stack, ... Molecular & Cellular Proteomics 7 (6), 1111-1123, 2008 | 155 | 2008 |
| The chemical basis of serine palmitoyltransferase inhibition by myriocin JM Wadsworth, DJ Clarke, SA McMahon, JP Lowther, AE Beattie, ... Journal of the American Chemical Society 135 (38), 14276-14285, 2013 | 137 | 2013 |
| Structural and functional relationships in the virulence-associated cathepsin L proteases of the parasitic liver fluke, Fasciola hepatica CM Stack, CR Caffrey, SM Donnelly, A Seshaadri, J Lowther, JF Tort, ... Journal of Biological Chemistry 283 (15), 9896-9908, 2008 | 112 | 2008 |
| Structural and functional relationships in the virulence-associated cathepsin L proteases of the parasitic liver fluke, Fasciola hepatica CM Stack, CR Caffrey, SM Donnelly, A Seshaadri, J Lowther, JF Tort, ... Journal of Biological Chemistry 283 (15), 9896-9908, 2008 | 112 | 2008 |
| Structural, mechanistic and regulatory studies of serine palmitoyltransferase J Lowther, JH Naismith, TM Dunn, DJ Campopiano Biochemical Society Transactions 40 (3), 547-554, 2012 | 109 | 2012 |
| Identification of phosphinate dipeptide analog inhibitors directed against the Plasmodium falciparum M17 leucine aminopeptidase as lead antimalarial compounds TS Skinner-Adams, J Lowther, F Teuscher, CM Stack, J Grembecka, ... Journal of medicinal chemistry 50 (24), 6024-6031, 2007 | 109 | 2007 |
| Identification of phosphinate dipeptide analog inhibitors directed against the Plasmodium falciparum M17 leucine aminopeptidase as lead antimalarial compounds TS Skinner-Adams, J Lowther, F Teuscher, CM Stack, J Grembecka, ... Journal of medicinal chemistry 50 (24), 6024-6031, 2007 | 109 | 2007 |
| Proteolytic Degradation of Hemoglobin in the Intestine of the Human Hookworm Necator americanus N Ranjit, B Zhan, B Hamilton, D Stenzel, J Lowther, M Pearson, J Gorman, ... The Journal of infectious diseases 199 (6), 904-912, 2009 | 108 | 2009 |
| Structure of the Plasmodium falciparum M17 aminopeptidase and significance for the design of drugs targeting the neutral exopeptidases S McGowan, CA Oellig, WA Birru, TT Caradoc-Davies, CM Stack, ... Proceedings of the National Academy of Sciences 107 (6), 2449-2454, 2010 | 100 | 2010 |
| The Importance of pH in Regulating the Function of the Fasciola hepatica Cathepsin L1 Cysteine Protease J Lowther, MW Robinson, SM Donnelly, W Xu, CM Stack, JM Matthews, ... PLoS neglected tropical diseases 3 (1), e369, 2009 | 91 | 2009 |
| The external aldimine form of serine palmitoyltransferase: structural, kinetic, and spectroscopic analysis of the wild-type enzyme and HSAN1 mutant mimics MCC Raman, KA Johnson, BA Yard, J Lowther, LG Carter, JH Naismith, ... Journal of Biological Chemistry 284 (25), 17328-17339, 2009 | 70 | 2009 |
| The M18 aspartyl aminopeptidase of the human malaria parasite Plasmodium falciparum F Teuscher, J Lowther, TS Skinner-Adams, T Spielmann, MWA Dixon, ... Journal of Biological Chemistry 282 (42), 30817-30826, 2007 | 67 | 2007 |
| The M18 aspartyl aminopeptidase of the human malaria parasite Plasmodium falciparum F Teuscher, J Lowther, TS Skinner-Adams, T Spielmann, MWA Dixon, ... Journal of Biological Chemistry 282 (42), 30817-30826, 2007 | 67 | 2007 |
| The M17 Leucine Aminopeptidase of the Malaria Parasite Plasmodium falciparum: Importance of Active Site Metal Ions in the Binding of Substrates and Inhibitors S Maric, SM Donnelly, MW Robinson, T Skinner-Adams, KR Trenholme, ... Biochemistry 48 (23), 5435-5439, 2009 | 60 | 2009 |
| Inhibition of the PLP-dependent enzyme serine palmitoyltransferase by cycloserine: evidence for a novel decarboxylative mechanism of inactivation J Lowther, BA Yard, KA Johnson, LG Carter, VT Bhat, MCC Raman, ... Molecular BioSystems 6 (9), 1682-1693, 2010 | 58 | 2010 |
| Aminopeptidases of malaria parasites: new targets for chemotherapy K R Trenholme, C L Brown, T S Skinner-Adams, C Stack, J Lowther, J To, ... Infectious Disorders-Drug Targets (Formerly Current Drug Targets-Infectious …, 2010 | 37 | 2010 |
