Kasper Harpsøe
Kasper Harpsøe
Department of Drug Design and Pharmacology, University of Copenhagen
Verified email at - Homepage
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GPCRdb in 2018: adding GPCR structure models and ligands
G Pándy-Szekeres, C Munk, TM Tsonkov, S Mordalski, K Harpsøe, ...
Nucleic acids research 46 (D1), D440-D446, 2018
GPCRdb: an information system for G protein-coupled receptors
V Isberg, S Mordalski, C Munk, K Rataj, K Harpsøe, AS Hauser, B Vroling, ...
Nucleic acids research 44 (D1), D356-D364, 2016
5-HT2C receptor structures reveal the structural basis of GPCR polypharmacology
Y Peng, JD McCorvy, K Harpsøe, K Lansu, S Yuan, P Popov, L Qu, M Pu, ...
Cell 172 (4), 719-730. e14, 2018
GPCRdb: the G protein‐coupled receptor database–an introduction
C Munk, V Isberg, S Mordalski, K Harpsøe, K Rataj, AS Hauser, P Kolb, ...
British Journal of Pharmacology 173 (14), 2195-2207, 2016
Structural insights into the lipid and ligand regulation of serotonin receptors
P Xu, S Huang, H Zhang, C Mao, XE Zhou, X Cheng, IA Simon, DD Shen, ...
Nature 592 (7854), 469-473, 2021
Unraveling the high-and low-sensitivity agonist responses of nicotinic acetylcholine receptors
K Harpsøe, PK Ahring, JK Christensen, ML Jensen, D Peters, T Balle
Journal of Neuroscience 31 (30), 10759-10766, 2011
Total synthesis and structure–activity relationship studies of a series of selective G protein inhibitors
XF Xiong, H Zhang, CR Underwood, K Harpsøe, TJ Gardella, MF Wöldike, ...
Nature chemistry 8 (11), 1035-1041, 2016
Structural proof of a dimeric positive modulator bridging two identical AMPA receptor-binding sites
BH Kaae, K Harpsøe, JS Kastrup, AC Sanz, DS Pickering, B Metzler, ...
Chemistry & biology 14 (11), 1294-1303, 2007
GPCRs steer Gi and Gs selectivity via TM5-TM6 switches as revealed by structures of serotonin receptors
S Huang, P Xu, DD Shen, IA Simon, C Mao, Y Tan, H Zhang, K Harpsøe, ...
Molecular cell 82 (14), 2681-2695. e6, 2022
Rational design of α-conotoxin analogues targeting α7 nicotinic acetylcholine receptors
C Armishaw, AA Jensen, T Balle, RJ Clark, K Harpsøe, C Skonberg, ...
Journal of Biological Chemistry 284 (14), 9498-9512, 2009
Integrating structural and mutagenesis data to elucidate GPCR ligand binding
C Munk, K Harpsøe, AS Hauser, V Isberg, DE Gloriam
Current opinion in pharmacology 30, 51-58, 2016
Intersubunit bridge formation governs agonist efficacy at nicotinic acetylcholine α4β2 receptors
LAH Rohde, PK Ahring, ML Jensen, EØ Nielsen, D Peters, C Helgstrand, ...
Journal of Biological Chemistry 287 (6), 4248-4259, 2012
GPCRdb: an information system for G protein-coupled receptors
V Isberg, S Mordalski, C Munk, K Rataj, K Harpsøe, AS Hauser, B Vroling, ...
Nucleic Acids Research 45 (5), 2936-2936, 2017
Selective negative allosteric modulation of metabotropic glutamate receptors–a structural perspective of ligands and mutants
K Harpsøe, V Isberg, BG Tehan, D Weiss, A Arsova, FH Marshall, ...
Scientific reports 5 (1), 13869, 2015
Rational design of a heterotrimeric G protein α subunit with artificial inhibitor sensitivity
D Malfacini, J Patt, S Annala, K Harpsøe, F Eryilmaz, R Reher, ...
Journal of Biological Chemistry 294 (15), 5747-5758, 2019
Development of a human vasopressin V1a-receptor antagonist from an evolutionary-related insect neuropeptide
MG Di Giglio, M Muttenthaler, K Harpsøe, Z Liutkeviciute, P Keov, T Eder, ...
Scientific Reports 7 (1), 41002, 2017
Pharmacological characterization and modeling of the binding sites of novel 1, 3-bis (pyridinylethynyl) benzenes as metabotropic glutamate receptor 5-selective negative …
C Mølck, K Harpsøe, DE Gloriam, RP Clausen, U Madsen, LØ Pedersen, ...
Molecular pharmacology 82 (5), 929-937, 2012
mGluR5: exploration of orthosteric and allosteric ligand binding pockets and their applications to drug discovery
C Mølck, K Harpsøe, DE Gloriam, JM Mathiesen, SM Nielsen, ...
Neurochemical research 39, 1862-1875, 2014
Discovery of a novel allosteric modulator of 5-HT3 receptors: inhibition and potentiation of Cys-loop receptor signaling through a conserved transmembrane intersubunit site
SM Trattnig, K Harpsøe, SB Thygesen, LM Rahr, PK Ahring, T Balle, ...
Journal of Biological Chemistry 287 (30), 25241-25254, 2012
Molecular determinants of subtype-selective efficacies of cytisine and the novel compound NS3861 at heteromeric nicotinic acetylcholine receptors
K Harpsøe, H Hald, DB Timmermann, ML Jensen, T Dyhring, EØ Nielsen, ...
Journal of Biological Chemistry 288 (4), 2559-2570, 2013
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