Spencer Freeman
Spencer Freeman
The Hospital for Sick Children, Cell Biology Program
Verified email at - Homepage
Cited by
Cited by
Phagocytosis: receptors, signal integration, and the cytoskeleton
SA Freeman, S Grinstein
Immunological reviews 262 (1), 193-215, 2014
VAPs and ACBD5 tether peroxisomes to the ER for peroxisome maintenance and lipid homeostasis
R Hua, D Cheng, É Coyaud, S Freeman, E Di Pietro, Y Wang, A Vissa, ...
Journal of Cell Biology 216 (2), 367-377, 2017
Abelson-interactor-1 promotes WAVE2 membrane translocation and Abelson-mediated tyrosine phosphorylation required for WAVE2 activation
Y Leng, J Zhang, K Badour, E Arpaia, S Freeman, P Cheung, M Siu, ...
Proceedings of the National Academy of Sciences 102 (4), 1098-1103, 2005
Phosphoinositide 3-kinase enables phagocytosis of large particles by terminating actin assembly through Rac/Cdc42 GTPase-activating proteins
D Schlam, RD Bagshaw, SA Freeman, RF Collins, T Pawson, GD Fairn, ...
Nature communications 6 (1), 8623, 2015
Transmembrane pickets connect cyto-and pericellular skeletons forming barriers to receptor engagement
SA Freeman, A Vega, M Riedl, RF Collins, PP Ostrowski, EC Woods, ...
Cell 172 (1), 305-317. e10, 2018
Integrins form an expanding diffusional barrier that coordinates phagocytosis
SA Freeman, J Goyette, W Furuya, EC Woods, CR Bertozzi, W Bergmeier, ...
Cell 164 (1), 128-140, 2016
(R)-PFI-2 is a potent and selective inhibitor of SETD7 methyltransferase activity in cells
D Barsyte-Lovejoy, F Li, MJ Oudhoff, JH Tatlock, A Dong, H Zeng, H Wu, ...
Proceedings of the National Academy of Sciences 111 (35), 12853-12858, 2014
Control of the hippo pathway by Set7-dependent methylation of Yap
MJ Oudhoff, SA Freeman, AL Couzens, F Antignano, E Kuznetsova, ...
Developmental cell 26 (2), 188-194, 2013
Interaction of the Wiskott–Aldrich syndrome protein with sorting nexin 9 is required for CD28 endocytosis and cosignaling in T cells
K Badour, MKH McGavin, J Zhang, S Freeman, C Vieira, D Filipp, M Julius, ...
Proceedings of the National Academy of Sciences 104 (5), 1593-1598, 2007
Lipid-gated monovalent ion fluxes regulate endocytic traffic and support immune surveillance
SA Freeman, S Uderhardt, A Saric, RF Collins, CM Buckley, ...
Science 367 (6475), 301-305, 2020
Cofilin-mediated F-actin severing is regulated by the Rap GTPase and controls the cytoskeletal dynamics that drive lymphocyte spreading and BCR microcluster formation
SA Freeman, V Lei, M Dang-Lawson, K Mizuno, CD Roskelley, MR Gold
The Journal of Immunology 187 (11), 5887-5900, 2011
The cytoskeleton in phagocytosis and macropinocytosis
S Mylvaganam, SA Freeman, S Grinstein
Current Biology 31 (10), R619-R632, 2021
The rap GTPases regulate B cell morphology, immune-synapse formation, and signaling by particulate B cell receptor ligands
KBL Lin, SA Freeman, S Zabetian, H Brugger, M Weber, V Lei, ...
Immunity 28 (1), 75-87, 2008
SETD7 controls intestinal regeneration and tumorigenesis by regulating Wnt/β-catenin and Hippo/YAP signaling
MJ Oudhoff, MJS Braam, SA Freeman, D Wong, DG Rattray, J Wang, ...
Developmental cell 37 (1), 47-57, 2016
Toll-like receptor ligands sensitize B-cell receptor signalling by reducing actin-dependent spatial confinement of the receptor
SA Freeman, V Jaumouillé, K Choi, BE Hsu, HS Wong, L Abraham, ...
Nature communications 6 (1), 6168, 2015
Phagocytosis by the retinal pigment epithelium: recognition, resolution, recycling
W Kwon, SA Freeman
Frontiers in immunology 11, 604205, 2020
Diffusion barriers, mechanical forces, and the biophysics of phagocytosis
PP Ostrowski, S Grinstein, SA Freeman
Developmental cell 38 (2), 135-146, 2016
Lipid peroxidation increases membrane tension, Piezo1 gating, and cation permeability to execute ferroptosis
Y Hirata, R Cai, A Volchuk, BE Steinberg, Y Saito, A Matsuzawa, ...
Current Biology 33 (7), 1282-1294. e5, 2023
Multistep track segmentation and motion classification for transient mobility analysis
AR Vega, SA Freeman, S Grinstein, K Jaqaman
Biophysical journal 114 (5), 1018-1025, 2018
Gain-of-function variants in SYK cause immune dysregulation and systemic inflammation in humans and mice
L Wang, D Aschenbrenner, Z Zeng, X Cao, D Mayr, M Mehta, M Capitani, ...
Nature genetics 53 (4), 500-510, 2021
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