Clonally expanded B cells in multiple sclerosis bind EBV EBNA1 and GlialCAM TV Lanz, RC Brewer, PP Ho, JS Moon, KM Jude, D Fernandez, ... Nature 603 (7900), 321-327, 2022 | 468 | 2022 |
Itraconazole and arsenic trioxide inhibit Hedgehog pathway activation and tumor growth associated with acquired resistance to smoothened antagonists J Kim, BT Aftab, JY Tang, D Kim, AH Lee, M Rezaee, J Kim, B Chen, ... Cancer cell 23 (1), 23-34, 2013 | 397 | 2013 |
Targeting the AAA ATPase p97 as an approach to treat cancer through disruption of protein homeostasis DJ Anderson, R Le Moigne, S Djakovic, B Kumar, J Rice, S Wong, J Wang, ... Cancer cell 28 (5), 653-665, 2015 | 386 | 2015 |
Epstein–Barr virus in multiple sclerosis: theory and emerging immunotherapies A Bar-Or, MP Pender, R Khanna, L Steinman, HP Hartung, T Maniar, ... Trends in molecular medicine 26 (3), 296-310, 2020 | 263 | 2020 |
Itraconazole inhibits angiogenesis and tumor growth in non–small cell lung cancer BT Aftab, I Dobromilskaya, JO Liu, CM Rudin Cancer research 71 (21), 6764-6772, 2011 | 202 | 2011 |
Phase 2 study of pemetrexed and itraconazole as second-line therapy for metastatic nonsquamous non–small-cell lung cancer CM Rudin, JR Brahmer, RA Juergens, CL Hann, DS Ettinger, R Sebree, ... Journal of Thoracic Oncology 8 (5), 619-623, 2013 | 169 | 2013 |
Epstein-Barr virus–specific T cell therapy for progressive multiple sclerosis MP Pender, PA Csurhes, C Smith, NL Douglas, MA Neller, KK Matthews, ... JCI insight 3 (22), 2018 | 143 | 2018 |
Validation of the Hsp70–Bag3 protein–protein interaction as a potential therapeutic target in cancer X Li, T Colvin, JN Rauch, D Acosta-Alvear, M Kampmann, B Dunyak, ... Molecular cancer therapeutics 14 (3), 642-648, 2015 | 134 | 2015 |
The p97 inhibitor CB-5083 is a unique disrupter of protein homeostasis in models of multiple myeloma R Le Moigne, BT Aftab, S Djakovic, E Dhimolea, E Valle, M Murnane, ... Molecular cancer therapeutics 16 (11), 2375-2386, 2017 | 109 | 2017 |
Molecular signature of Epstein-Barr virus infection in MS brain lesions MA Moreno, N Or-Geva, BT Aftab, R Khanna, E Croze, L Steinman, ... Neurology: Neuroimmunology & Neuroinflammation 5 (4), e466, 2018 | 99 | 2018 |
Bridging the gap between preclinical and clinical studies using pharmacokinetic–pharmacodynamic modeling: an analysis of GDC-0973, a MEK inhibitor H Wong, L Vernillet, A Peterson, JA Ware, L Lee, JF Martini, P Yu, C Li, ... Clinical Cancer Research 18 (11), 3090-3099, 2012 | 96 | 2012 |
Antibody-drug conjugate targeting CD46 eliminates multiple myeloma cells DW Sherbenou, BT Aftab, Y Su, CR Behrens, A Wiita, AC Logan, ... The Journal of clinical investigation 126 (12), 4640-4653, 2016 | 94 | 2016 |
Off-the-shelf Vδ1 gamma delta T cells engineered with glypican-3 (GPC-3)-specific chimeric antigen receptor (CAR) and soluble IL-15 display robust antitumor efficacy against … A Makkouk, XC Yang, T Barca, A Lucas, M Turkoz, JTS Wong, ... Journal for immunotherapy of cancer 9 (12), 2021 | 92 | 2021 |
A polymeric nanoparticle encapsulated small-molecule inhibitor of Hedgehog signaling (NanoHHI) bypasses secondary mutational resistance to Smoothened antagonists V Chenna, C Hu, D Pramanik, BT Aftab, C Karikari, NR Campbell, ... Molecular cancer therapeutics 11 (1), 165-173, 2012 | 89 | 2012 |
Itraconazole side chain analogues: structure–activity relationship studies for inhibition of endothelial cell proliferation, vascular endothelial growth factor receptor 2 … W Shi, BA Nacev, BT Aftab, S Head, CM Rudin, JO Liu Journal of medicinal chemistry 54 (20), 7363-7374, 2011 | 76 | 2011 |
Compositions comprising anti-CD38 antibodies and lenalidomide BC Hann, B Tomkinson, TG Martin III, BT Aftab US Patent 10,342,869, 2019 | 53 | 2019 |
Allogeneic CD20‐targeted γδ T cells exhibit innate and adaptive antitumor activities in preclinical B‐cell lymphoma models KP Nishimoto, T Barca, A Azameera, A Makkouk, JM Romero, L Bai, ... Clinical & Translational Immunology 11 (2), e1373, 2022 | 51 | 2022 |
Genome-wide association study identifies variants at 16p13 associated with survival in multiple myeloma patients E Ziv, E Dean, D Hu, A Martino, D Serie, K Curtin, D Campa, B Aftab, ... Nature communications 6 (1), 7539, 2015 | 49 | 2015 |
Hedgehog pathway inhibition radiosensitizes non-small cell lung cancers J Zeng, K Aziz, ST Chettiar, BT Aftab, M Armour, R Gajula, N Gandhi, ... International Journal of Radiation Oncology* Biology* Physics 86 (1), 143-149, 2013 | 48 | 2013 |
Profiling HPV-16–specific T cell responses reveals broad antigen reactivities in oropharyngeal cancer patients KH Bhatt, MA Neller, S Srihari, P Crooks, L Lekieffre, BT Aftab, H Liu, ... Journal of Experimental Medicine 217 (10), e20200389, 2020 | 46 | 2020 |