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George R Young
George R Young
MRC Laboratory of Medical Sciences
Verified email at crick.ac.uk
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Cited by
Cited by
Year
The axolotl genome and the evolution of key tissue formation regulators
S Nowoshilow, S Schloissnig, JF Fei, A Dahl, AWC Pang, M Pippel, ...
Nature 554 (7690), 50-55, 2018
5252018
Z-nucleic-acid sensing triggers ZBP1-dependent necroptosis and inflammation
H Jiao, L Wachsmuth, S Kumari, R Schwarzer, J Lin, RO Eren, A Fisher, ...
Nature 580 (7803), 391-395, 2020
2722020
Resurrection of endogenous retroviruses in antibody-deficient mice
GR Young, U Eksmond, R Salcedo, L Alexopoulou, JP Stoye, G Kassiotis
Nature 491 (7426), 774-778, 2012
2342012
The genome of Schmidtea mediterranea and the evolution of core cellular mechanisms
MA Grohme, S Schloissnig, A Rozanski, M Pippel, GR Young, S Winkler, ...
Nature 554 (7690), 56-61, 2018
2132018
Are human endogenous retroviruses pathogenic? An approach to testing the hypothesis
GR Young, JP Stoye, G Kassiotis
Bioessays 35 (9), 794-803, 2013
1002013
Tissue-specific and interferon-inducible expression of nonfunctional ACE2 through endogenous retroelement co-option
KW Ng, J Attig, W Bolland, GR Young, J Major, AG Wrobel, S Gamblin, ...
Nature genetics 52 (12), 1294-1302, 2020
882020
ADAR1 averts fatal type I interferon induction by ZBP1
H Jiao, L Wachsmuth, S Wolf, J Lohmann, M Nagata, GG Kaya, ...
Nature 607 (7920), 776-783, 2022
872022
Antibodies against endogenous retroviruses promote lung cancer immunotherapy
KW Ng, J Boumelha, KSS Enfield, J Almagro, H Cha, O Pich, T Karasaki, ...
Nature, 1-11, 2023
732023
LTR retroelement expansion of the human cancer transcriptome and immunopeptidome revealed by de novo transcript assembly
J Attig, GR Young, L Hosie, D Perkins, V Encheva-Yokoya, JP Stoye, ...
Genome research 29 (10), 1578-1590, 2019
732019
Adenosine-to-inosine editing of endogenous Z-form RNA by the deaminase ADAR1 prevents spontaneous MAVS-dependent type I interferon responses
Q Tang, RE Rigby, GR Young, AK Hvidt, T Davis, TK Tan, A Bridgeman, ...
Immunity 54 (9), 1961-1975. e5, 2021
682021
Negative selection by an endogenous retrovirus promotes a higher-avidity CD4+ T cell response to retroviral infection
GR Young, MJ Ploquin, U Eksmond, M Wadwa, JP Stoye, G Kassiotis
PLoS Pathog 8 (5), e1002709, 2012
612012
Opposing Development of Cytotoxic and Follicular Helper CD4 T Cells Controlled by the TCF-1-Bcl6 Nexus
T Donnarumma, GR Young, J Merkenschlager, U Eksmond, N Bongard, ...
Cell Reports 17 (6), 1571-1583, 2016
592016
Soluble PD-L1 generated by endogenous retroelement exaptation is a receptor antagonist
KW Ng, J Attig, GR Young, E Ottina, SI Papamichos, I Kotsianidis, ...
elife 8, e50256, 2019
522019
HIV-1 interacts with human endogenous retrovirus K (HML-2) envelopes derived from human primary lymphocytes
D Brinzevich, GR Young, R Sebra, J Ayllon, SM Maio, G Deikus, BK Chen, ...
Journal of virology 88 (11), 6213-6223, 2014
522014
Microarray analysis reveals global modulation of endogenous retroelement transcription by microbes
GR Young, B Mavrommatis, G Kassiotis
Retrovirology 11 (1), 59, 2014
502014
Permissive selection followed by affinity-based proliferation of GC light zone B cells dictates cell fate and ensures clonal breadth
R Nakagawa, A Toboso-Navasa, M Schips, G Young, L Bhaw-Rosun, ...
Proceedings of the National Academy of Sciences 118 (2), e2016425118, 2021
472021
HIV-1 Infection of Primary CD4+ T Cells Regulates the Expression of Specific Human Endogenous Retrovirus HERV-K (HML-2) Elements
GR Young, SN Terry, L Manganaro, A Cuesta-Dominguez, G Deikus, ...
Journal of virology 92 (1), e01507-17, 2018
372018
Physiological and Pathological Transcriptional Activation of Endogenous Retroelements Assessed By RNA-Sequencing of B lymphocytes
J Attig, GR Young, J Stoye, G Kassiotis
Frontiers in Microbiology 8, 2489, 2017
372017
SARS-CoV-2 ORF6 disrupts innate immune signalling by inhibiting cellular mRNA export
R Hall, A Guedán, MW Yap, GR Young, R Harvey, JP Stoye, KN Bishop
PLoS pathogens 18 (8), e1010349, 2022
262022
Epigenetic therapy of myelodysplastic syndromes connects to cellular differentiation independently of endogenous retroelement derepression
A Kazachenka, GR Young, J Attig, C Kordella, E Lamprianidou, E Zoulia, ...
Genome Medicine 11 (1), 1-18, 2019
242019
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Articles 1–20