Absence of colony stimulation factor-1 receptor results in loss of microglia, disrupted brain development and olfactory deficits B Erblich, L Zhu, AM Etgen, K Dobrenis, JW Pollard PloS one 6 (10), e26317, 2011 | 684 | 2011 |
Chronic cyclodextrin treatment of murine Niemann-Pick C disease ameliorates neuronal cholesterol and glycosphingolipid storage and disease progression CD Davidson, NF Ali, MC Micsenyi, G Stephney, S Renault, K Dobrenis, ... PloS one 4 (9), e6951, 2009 | 530 | 2009 |
Microglial stimulation of glioblastoma invasion involves epidermal growth factor receptor (EGFR) and colony stimulating factor 1 receptor (CSF-1R) signaling SJ Coniglio, E Eugenin, K Dobrenis, ER Stanley, BL West, MH Symons, ... Molecular medicine 18, 519-527, 2012 | 467 | 2012 |
Neurons in Niemann-Pick disease type C accumulate gangliosides as well as unesterified cholesterol and undergo dendritic and axonal alterations M Zervas, K Dobrenis, SU Walkley Journal of Neuropathology & Experimental Neurology 60 (1), 49-64, 2001 | 289 | 2001 |
Differential subcellular localization of cholesterol, gangliosides, and glycosaminoglycans in murine models of mucopolysaccharide storage disorders R McGlynn, K Dobrenis, SU Walkley Journal of Comparative Neurology 480 (4), 415-426, 2004 | 281 | 2004 |
Bone marrow transplantation corrects the enzyme defect in neurons of the central nervous system in a lysosomal storage disease. SU Walkley, MA Thrall, K Dobrenis, M Huang, PA March, DA Siegel, ... Proceedings of the National Academy of Sciences 91 (8), 2970-2974, 1994 | 207 | 1994 |
A mouse model for mucopolysaccharidosis type III A (Sanfilippo syndrome) M Bhaumik, VJ Muller, T Rozaklis, J Linda, K Dobrenis, R Bhattacharyya, ... Glycobiology 9 (12), 1389-1396, 1999 | 203 | 1999 |
Neuronal accumulation of glucosylceramide in a mouse model of neuronopathic Gaucher disease leads to neurodegeneration T Farfel-Becker, EB Vitner, SL Kelly, JR Bame, J Duan, V Shinder, ... Human molecular genetics 23 (4), 843-854, 2014 | 163 | 2014 |
Macroautophagy is defective in mucolipin-1-deficient mouse neurons C Curcio-Morelli, FA Charles, MC Micsenyi, Y Cao, B Venugopal, ... Neurobiology of disease 40 (2), 370-377, 2010 | 128 | 2010 |
Human and mouse microglia express connexin36, and functional gap junctions are formed between rodent microglia and neurons K Dobrenis, HY Chang, MH Pina‐Benabou, A Woodroffe, SC Lee, ... Journal of neuroscience research 82 (3), 306-315, 2005 | 123 | 2005 |
Efficacy and ototoxicity of different cyclodextrins in Niemann–Pick C disease CD Davidson, YI Fishman, I Puskás, J Szemán, T Sohajda, LA McCauliff, ... Annals of Clinical and Translational Neurology 3 (5), 366-380, 2016 | 117 | 2016 |
Neuropathology of the Mcoln1−/− Knockout Mouse Model of Mucolipidosis Type IV MC Micsenyi, K Dobrenis, G Stephney, J Pickel, MT Vanier, ... Journal of Neuropathology & Experimental Neurology 68 (2), 125-135, 2009 | 116 | 2009 |
X-linked Angelman-like syndrome caused by Slc9a6 knockout in mice exhibits evidence of endosomal–lysosomal dysfunction P Strĝmme, K Dobrenis, RV Sillitoe, M Gulinello, NF Ali, C Davidson, ... Brain 134 (11), 3369-3383, 2011 | 103 | 2011 |
Microglia in cell culture and in transplantation therapy for central nervous system disease K Dobrenis Methods 16 (3), 320-344, 1998 | 102 | 1998 |
Protein transduction of Rab9 in Niemann‐Pick C cells reduces cholesterol storage K Narita, A Choudhury, K Dobrenis, DK Sharma, EL Holicky, DL Marks, ... The FASEB journal 19 (11), 1558-1560, 2005 | 100 | 2005 |
Neuronal lysosomal enzyme replacement using fragment C of tetanus toxin. K Dobrenis, A Joseph, MC Rattazzi Proceedings of the National Academy of Sciences 89 (6), 2297-2301, 1992 | 93 | 1992 |
Occurrence of the opiate alkaloid-selective μ3 receptor in mammalian microglia, astrocytes and Kupffer cells K Dobrenis, MH Makman, GB Stefano Brain research 686 (2), 239-248, 1995 | 90 | 1995 |
Granulocyte colony‐stimulating factor off‐target effect on nerve outgrowth promotes prostate cancer development K Dobrenis, LR Gauthier, V Barroca, C Magnon International journal of cancer 136 (4), 982-988, 2015 | 81 | 2015 |
Inhibition of lysosome membrane recycling causes accumulation of gangliosides that contribute to neurodegeneration M Boutry, J Branchu, C Lustremant, C Pujol, J Pernelle, R Matusiak, ... Cell reports 23 (13), 3813-3826, 2018 | 76 | 2018 |
Lysosomal membrane permeability stimulates protein aggregate formation in neurons of a lysosomal disease MC Micsenyi, J Sikora, G Stephney, K Dobrenis, SU Walkley Journal of Neuroscience 33 (26), 10815-10827, 2013 | 73 | 2013 |