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Alexander Sebastian Hauser
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Trends in GPCR drug discovery: new agents, targets and indications
AS Hauser, MM Attwood, M Rask-Andersen, HB Schiöth, DE Gloriam
Nature reviews Drug discovery 16 (12), 829-842, 2017
23502017
Pharmacogenomics of GPCR drug targets
AS Hauser, S Chavali, I Masuho, LJ Jahn, KA Martemyanov, DE Gloriam, ...
Cell 172 (1), 41-54. e19, 2018
6242018
GPCRdb in 2018: adding GPCR structure models and ligands
G Pándy-Szekeres, C Munk, TM Tsonkov, S Mordalski, K Harpsøe, ...
Nucleic acids research 46 (D1), D440-D446, 2018
5372018
GPCRDB: an information system for G protein-coupled receptors
V Isberg, B Vroling, R van der Kant, K Li, G Vriend, D Gloriam
Nucleic acids research 42 (D1), D422-D425, 2013
492*2013
Selectivity determinants of GPCR–G-protein binding
T Flock, AS Hauser, N Lund, DE Gloriam, S Balaji, MM Babu
Nature 545 (7654), 317-322, 2017
3792017
GPCRdb: the G protein‐coupled receptor database–an introduction
C Munk, V Isberg, S Mordalski, K Harpsøe, K Rataj, AS Hauser, P Kolb, ...
British Journal of Pharmacology 173 (14), 2195-2207, 2016
2302016
Discovery of human signaling systems: pairing peptides to G protein-coupled receptors
SR Foster, AS Hauser, L Vedel, RT Strachan, XP Huang, AC Gavin, ...
Cell 179 (4), 895-908. e21, 2019
1942019
GPCR activation mechanisms across classes and macro/microscales
AS Hauser, AJ Kooistra, C Munk, FM Heydenreich, DB Veprintsev, ...
Nature structural & molecular biology 28 (11), 879-888, 2021
1382021
Effector membrane translocation biosensors reveal G protein and βarrestin coupling profiles of 100 therapeutically relevant GPCRs
C Avet, A Mancini, B Breton, C Le Gouill, AS Hauser, C Normand, ...
Elife 11, e74101, 2022
1332022
LEADS-PEP: a benchmark data set for assessment of peptide docking performance
AS Hauser, B Windshügel
Journal of Chemical Information and Modeling 56 (1), 188-200, 2016
932016
Common coupling map advances GPCR-G protein selectivity
AS Hauser, C Avet, C Normand, A Mancini, A Inoue, M Bouvier, ...
Elife 11, e74107, 2022
812022
The G protein database, GproteinDb
G Pándy-Szekeres, M Esguerra, AS Hauser, J Caroli, C Munk, S Pilger, ...
Nucleic Acids Research 50 (D1), D518-D525, 2022
602022
Integrating structural and mutagenesis data to elucidate GPCR ligand binding
C Munk, K Harpsøe, AS Hauser, V Isberg, DE Gloriam
Current opinion in pharmacology 30, 51-58, 2016
562016
Glaucoma clinical research: Trends in treatment strategies and drug development
L Storgaard, TL Tran, JC Freiberg, AS Hauser, M Kolko
Frontiers in Medicine 8, 733080, 2021
492021
Selectivity landscape of 100 therapeutically relevant GPCR profiled by an effector translocation-based BRET platform
C Avet, A Mancini, B Breton, C Le Gouill, A Hauser, C Normand, ...
422020
The orphan G protein-coupled receptor GPR139 is activated by the peptides: adrenocorticotropic hormone (ACTH), α-, and β-melanocyte stimulating hormone (α-MSH, and β-MSH), and …
AC Nøhr, MA Shehata, AS Hauser, V Isberg, J Mokrosinski, KB Andersen, ...
Neurochemistry international 102, 105-113, 2017
422017
Novel approaches leading towards peptide GPCR de‐orphanisation
AS Hauser, DE Gloriam, H Bräuner‐Osborne, SR Foster
British Journal of Pharmacology 177 (5), 961-968, 2020
362020
Receptor selectivity between the G proteins Gα12 and Gα13 is defined by a single leucine-to-isoleucine variation
AE Mackenzie, T Quon, LC Lin, AS Hauser, L Jenkins, A Inoue, AB Tobin, ...
The FASEB Journal 33 (4), 5005, 2019
302019
A new crystal structure fragment-based pharmacophore method for G protein-coupled receptors
K Fidom, V Isberg, AS Hauser, S Mordalski, T Lehto, AJ Bojarski, ...
Methods 71, 104-112, 2015
262015
Ligand-directed bias of G protein signaling at the dopamine D2 receptor
E Von Moo, K Harpsøe, AS Hauser, I Masuho, H Bräuner-Osborne, ...
Cell chemical biology 29 (2), 226-238. e4, 2022
242022
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Articles 1–20