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Kathleen A. Farley
Kathleen A. Farley
Verified email at pfizer.com
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Cited by
Cited by
Year
Delineating the role of cooperativity in the design of potent PROTACs for BTK
A Zorba, C Nguyen, Y Xu, J Starr, K Borzilleri, J Smith, H Zhu, KA Farley, ...
Proceedings of the National Academy of Sciences 115 (31), E7285-E7292, 2018
3182018
A New Resistance Gene, linB, Conferring Resistance to Lincosamides by Nucleotidylation in Enterococcus faecium HM1025
B Bozdogan, L Berrezouga, MS Kuo, DA Yurek, KA Farley, BJ Stockman, ...
Antimicrobial agents and chemotherapy 43 (4), 925-929, 1999
2391999
Discovery of cytotoxic dolastatin 10 analogues with N-terminal modifications
A Maderna, M Doroski, C Subramanyam, A Porte, CA Leverett, ...
Journal of medicinal chemistry 57 (24), 10527-10543, 2014
1402014
Optimizing PK properties of cyclic peptides: the effect of side chain substitutions on permeability and clearance
AC Rand, SSF Leung, H Eng, CJ Rotter, R Sharma, AS Kalgutkar, ...
MedChemComm 3 (10), 1282-1289, 2012
1362012
Integrating intramolecular hydrogen bonding (IMHB) considerations in drug discovery using ΔlogP as a tool
M Shalaeva, G Caron, YA Abramov, TN O’Connell, MS Plummer, ...
Journal of medicinal chemistry 56 (12), 4870-4879, 2013
952013
Non-uniform sampling for all: more NMR spectral quality, less measurement time
F Delaglio, GS Walker, KA Farley, R Sharma, JC Hoch, LW Arbogast, ...
American pharmaceutical review 20 (4), 2017
682017
Methods for creating a compound library and identifying lead chemical templates and ligands for target molecules
BJ Stockman, KA Farley, C Dalvit
US Patent 6,677,160, 2004
612004
Discovery of azetidinyl ketolides for the treatment of susceptible and multidrug resistant community-acquired respiratory tract infections
TV Magee, SL Ripp, B Li, RA Buzon, L Chupak, TJ Dougherty, ...
Journal of medicinal chemistry 52 (23), 7446-7457, 2009
582009
A new and useful method for the macrocyclization of linear peptides
AT Londregan, KA Farley, C Limberakis, PB Mullins, DW Piotrowski
Organic letters 14 (11), 2890-2893, 2012
542012
Screening of compound libraries for protein binding using flow-injection nuclear magnetic resonance spectroscopy
BJ Stockman, KA Farley, DT Angwin
Methods in enzymology 338, 230-246, 2002
412002
Increased HMBC sensitivity for correlating poorly resolved proton multiplets to carbon-13 using selective or semi-selective pulses
A Bax, KA Farley, GS Walker
Journal of Magnetic Resonance, Series A 119 (1), 134-138, 1996
411996
Design and evaluation of a 2-(2, 3, 6-trifluorophenyl) acetamide derivative as an agonist of the GPR119 receptor
V Mascitti, BD Stevens, C Choi, KF McClure, CRW Guimarães, KA Farley, ...
Bioorganic & medicinal chemistry letters 21 (5), 1306-1309, 2011
332011
Complete spectroscopic structural characterization of novobiocin, isonovobiocin, decarbamylnovobiocin, 2″‐(o‐Carbamyl)novobiocin, and novobiocin‐2″,3 …
FW Crow, WK Duholke, CE Hadden, RF Smith, TJ Thamann, BD Kaluzny, ...
Journal of heterocyclic chemistry 36 (2), 365-370, 1999
331999
Macrocyclizations for medicinal chemistry: Synthesis of druglike macrocycles by high-concentration Ullmann coupling
JC Collins, KA Farley, C Limberakis, S Liras, D Price, K James
The Journal of Organic Chemistry 77 (24), 11079-11090, 2012
312012
Hierarchical mesoporous bio-polymer/silica composites co-templated by trimethyl chitosan and a surfactant for controlled drug delivery
VK Rana, SS Park, S Parambadath, MJ Kim, SH Kim, S Mishra, RP Singh, ...
MedChemComm 2 (12), 1162-1166, 2011
312011
Long‐range two‐dimensional 1H–15N heteronuclear shift correlation at natural abundance using GHNMQC. A study of the reverse transcriptase inhibitor delavirdine
KA Farley, GS Walker, GE Martin
Magnetic resonance in chemistry 35 (10), 671-679, 1997
271997
Cyclic Peptide Design Guided by Residual Dipolar Couplings, J-Couplings, and Intramolecular Hydrogen Bond Analysis
KA Farley, Y Che, A Navarro-Vázquez, C Limberakis, D Anderson, J Yan, ...
The Journal of Organic Chemistry 84 (8), 4803-4813, 2019
262019
Comparative pharmacokinetic profile of cyclosporine (CsA) with a decapeptide and a linear analogue
DA Price, H Eng, KA Farley, GH Goetz, Y Huang, Z Jiao, AS Kalgutkar, ...
Organic & Biomolecular Chemistry 15 (12), 2501-2506, 2017
232017
The synthesis of C-13 functionalized pleuromutilins via C–H amidation and subsequent novel rearrangement product
DP Uccello, SM Miller, NA Dieterich, AF Stepan, SW Chung, KA Farley, ...
Tetrahedron letters 52 (33), 4247-4251, 2011
232011
Utilizing on‐and off‐line monitoring tools to follow a kinetic resolution step during flow synthesis
KA Farley, U Reilly, DP Anderson, BP Boscoe, MW Bundesmann, ...
Magnetic Resonance in Chemistry 55 (4), 348-354, 2017
212017
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