| Roles of conformational and positional adaptability in structure-based design of TMC125-R165335 (etravirine) and related non-nucleoside reverse transcriptase inhibitors that … K Das, AD Clark Jr, PJ Lewi, J Heeres, MR de Jonge, LMH Koymans, ... Journal of medicinal chemistry 47 (10), 2550-2560, 2004 | 642 | 2004 |
| In Search of a Novel Anti-HIV Drug: Multidisciplinary Coordination in the Discovery of 4-[[4-[[4-[(1E)-2-Cyanoethenyl]-2,6-dimethylphenyl]amino]-2- pyrimidinyl … PAJ Janssen, PJ Lewi, E Arnold, F Daeyaert, M De Jonge, J Heeres, ... Journal of medicinal chemistry 48 (6), 1901-1909, 2005 | 426 | 2005 |
| Evolution of anti-HIV drug candidates. Part 3: Diarylpyrimidine (DAPY) analogues DW Ludovici, BL De Corte, MJ Kukla, H Ye, CY Ho, MA Lichtenstein, ... Bioorganic & medicinal chemistry letters 11 (17), 2235-2239, 2001 | 285 | 2001 |
| Synopsis: synthesize and optimize system in silico HM Vinkers, MR de Jonge, FFD Daeyaert, J Heeres, LMH Koymans, ... Journal of medicinal chemistry 46 (13), 2765-2773, 2003 | 248 | 2003 |
| A computational model of the inhibition of Mycobacterium tuberculosis ATPase by a new drug candidate R207910 MR de Jonge, LHM Koymans, JEG Guillemont, A Koul, K Andries Proteins: Structure, Function, and Bioinformatics 67 (4), 971-980, 2007 | 175 | 2007 |
| Synthesis of novel diarylpyrimidine analogues and their antiviral activity against human immunodeficiency virus type 1 J Guillemont, E Pasquier, P Palandjian, D Vernier, S Gaurrand, PJ Lewi, ... Journal of medicinal chemistry 48 (6), 2072-2079, 2005 | 166 | 2005 |
| Heteroaryl amines as glycogen synthase kinase 3β inhibitors (GSK3 inhibitors) EJE Freyne, PJJA Buijnsters, M Willems, WCJ Embrechts, CJ Love, ... US Patent 7,514,445, 2009 | 156 | 2009 |
| Evolution of anti-hiv drug candidatespart 2: diaryltriazine (DATA) analogues DW Ludovici, RW Kavash, MJ Kukla, CY Ho, H Ye, BL De Corte, ... Bioorganic & medicinal chemistry letters 11 (17), 2229-2234, 2001 | 156 | 2001 |
| Regional scale tectonic evolution and the seismic velocity structure of the lithosphere and upper mantle: the Mediterranean region MR De Jonge, MJR Wortel, W Spakman Journal of Geophysical Research: Solid Earth 99 (B6), 12091-12108, 1994 | 142 | 1994 |
| HIV inhibiting pyrimidine derivative KJLM Andries, B De Corte, MR De Jonge, J Heeres, CY Ho, ... US Patent 6,197,779, 2001 | 123 | 2001 |
| HIV inhibiting pyrimidines derivatives JEG Guillemont, P Palandijian, MR De Jonge, LMH Koymans, HM Vinkers, ... US Patent 20,120,076,835, 2012 | 101* | 2012 |
| HIV replication inhibiting pyrimidines B De Corte, MR De Jonge, J Heeres, CY Ho, PAJ Janssen, RW Kavash, ... EP Patent 1,002,795, 2003 | 75* | 2003 |
| Design, synthesis, and SAR of a novel pyrazinone series with non-nucleoside HIV-1 reverse transcriptase inhibitory activity J Heeres, MR De Jonge, LMH Koymans, FFD Daeyaert, M Vinkers, ... Journal of medicinal chemistry 48 (6), 1910-1918, 2005 | 69 | 2005 |
| de B thune, MP; Azijn, H.; Pauwels, R.; Lewi, PJ; Janssen J Heeres, MR de Jonge, LMH Koymans, FDF Daeyaert, M Vinkers, ... J. Med. Chem 48, 1910, 2005 | 69* | 2005 |
| On the detection of multiple-binding modes of ligands to proteins, from biological, structural, and modeling data PJ Lewis, M De Jonge, F Daeyaert, L Koymans, M Vinkers, J Heeres, ... Journal of computer-aided molecular design 17, 129-134, 2003 | 63 | 2003 |
| Multivariate adaptive regression splines—Studies of HIV reverse transcriptase inhibitors QS Xu, M Daszykowski, B Walczak, F Daeyaert, MR De Jonge, J Heeres, ... Chemometrics and intelligent laboratory systems 72 (1), 27-34, 2004 | 57 | 2004 |
| HIV Inhibiting pyrimidine derivatives KJLM Andries, B De Corte, MR De Jonge, J Heeres, CY Ho, ... US Patent 6,440,986, 2002 | 53 | 2002 |
| Classification and Regression Trees Studies of HIV Reverse Transcriptase Inhibitors M Daszykowski, B Walczak, QS Xu, F Daeyaert, MR de Jonge, J Heeres, ... Journal of chemical information and computer sciences 44 (2), 716-726, 2004 | 50 | 2004 |
| A pharmacophore docking algorithm and its application to the cross‐docking of 18 HIV‐NNRTI's in their binding pockets F Daeyaert, M de Jonge, J Heeres, L Koymans, P Lewi, MH Vinkers, ... Proteins: Structure, Function, and Bioinformatics 54 (3), 526-533, 2004 | 48 | 2004 |
| TRISUBSTITUTED 1, 3, 5-TRIAZINE DERIVATIVES FOR TREATMENT OF HIV INFECTIONS FFD Daeyaert, B De Corte, MR De Jonge, J Heeres, YHO Chih, ... EP Patent 1,066,269, 2005 | 40* | 2005 |
