| Structure-based discovery of opioid analgesics with reduced side effects A Manglik, H Lin, DK Aryal, JD McCorvy, D Dengler, G Corder, A Levit, ... Nature 537 (7619), 185-190, 2016 | 911 | 2016 |
| PRESTO-Tango as an open-source resource for interrogation of the druggable human GPCRome WK Kroeze, MF Sassano, XP Huang, K Lansu, JD McCorvy, PM Giguère, ... Nature structural & molecular biology 22 (5), 362-369, 2015 | 578 | 2015 |
| Molecular control of δ-opioid receptor signalling G Fenalti, PM Giguere, V Katritch, XP Huang, AA Thompson, V Cherezov, ... Nature 506 (7487), 191-196, 2014 | 522 | 2014 |
| A new DREADD facilitates the multiplexed chemogenetic interrogation of behavior E Vardy, JE Robinson, C Li, RHJ Olsen, JF DiBerto, PM Giguere, ... Neuron 86 (4), 936-946, 2015 | 379 | 2015 |
| Regulators of G-protein signaling and their Gα substrates: promises and challenges in their use as drug discovery targets AJ Kimple, DE Bosch, PM Giguère, DP Siderovski Pharmacological reviews 63 (3), 728-749, 2011 | 306 | 2011 |
| The mitochondrial proteins NLRX1 and TUFM form a complex that regulates type I interferon and autophagy Y Lei, H Wen, Y Yu, DJ Taxman, L Zhang, DG Widman, KV Swanson, ... Immunity 36 (6), 933-946, 2012 | 277 | 2012 |
| Structural basis for bifunctional peptide recognition at human δ-opioid receptor G Fenalti, NA Zatsepin, C Betti, P Giguere, GW Han, A Ishchenko, W Liu, ... Nature structural & molecular biology 22 (3), 265-268, 2015 | 186 | 2015 |
| DREADDs: novel tools for drug discovery and development HM Lee, PM Giguere, BL Roth Drug discovery today 19 (4), 469-473, 2014 | 108 | 2014 |
| Nm23-H2 interacts with a G protein-coupled receptor to regulate its endocytosis through an Rac1-dependent mechanism MD Rochdi, G Laroche, E Dupré, P Giguere, A Lebel, V Watier, E Hamelin, ... Journal of Biological Chemistry 279 (18), 18981-18989, 2004 | 65 | 2004 |
| The RGS protein inhibitor CCG-4986 is a covalent modifier of the RGS4 Gα-interaction face AJ Kimple, FS Willard, PM Giguère, CA Johnston, V Mocanu, ... Biochimica et Biophysica Acta (BBA)-Proteins and Proteomics 1774 (9), 1213-1220, 2007 | 60 | 2007 |
| Oligomerization of the α and β isoforms of the thromboxane A2 receptor: relevance to receptor signaling and endocytosis G Laroche, MC Lépine, C Thériault, P Giguère, V Giguère, MA Gallant, ... Cellular signalling 17 (11), 1373-1383, 2005 | 59 | 2005 |
| Peroxiredoxin-4 interacts with and regulates the thromboxane A2 receptor P Giguère, ME Turcotte, E Hamelin, A Parent, J Brisson, G Laroche, ... FEBS letters 581 (20), 3863-3868, 2007 | 55 | 2007 |
| Relative ratios of human seasonal coronavirus antibodies predict the efficiency of cross-neutralization of SARS-CoV-2 spike binding to ACE2 Y Galipeau, V Siragam, G Laroche, E Marion, M Greig, M McGuinty, ... EBioMedicine 74, 2021 | 39 | 2021 |
| Optimization of 2-phenylcyclopropylmethylamines as selective serotonin 2C receptor agonists and their evaluation as potential antipsychotic agents J Cheng, PM Giguère, OK Onajole, W Lv, A Gaisin, H Gunosewoyo, ... Journal of medicinal chemistry 58 (4), 1992-2002, 2015 | 38 | 2015 |
| G Protein signaling modulator-3 inhibits the inflammasome activity of NLRP3 PM Giguère, BJ Gall, EAD Ezekwe, G Laroche, BK Buckley, C Kebaier, ... Journal of Biological Chemistry 289 (48), 33245-33257, 2014 | 38 | 2014 |
| ARF6 activation by Gαq signaling: Gαq forms molecular complexes with ARNO and ARF6 P Giguère, MD Rochdi, G Laroche, É Dupré, MR Whorton, RK Sunahara, ... Cellular signalling 18 (11), 1988-1994, 2006 | 37 | 2006 |
| A non-canonical function of Gβ as a subunit of E3 ligase in targeting GRK2 ubiquitylation Z Zha, X Han, MD Smith, Y Liu, PM Giguère, D Kopanja, P Raychaudhuri, ... Molecular cell 58 (5), 794-803, 2015 | 36 | 2015 |
| High efficiency transient transfection of genes in human umbilical vein endothelial cells by electroporation T Ear, P Giguère, A Fleury, J Stankova, MD Payet, G Dupuis Journal of immunological methods 257 (1-2), 41-49, 2001 | 35 | 2001 |
| Design and Discovery of Functionally Selective Serotonin 2C (5-HT2C) Receptor Agonists J Cheng, JD McCorvy, PM Giguere, H Zhu, T Kenakin, BL Roth, ... Journal of medicinal chemistry 59 (21), 9866-9880, 2016 | 32 | 2016 |
| G-protein signaling modulator-3, a gene linked to autoimmune diseases, regulates monocyte function and its deficiency protects from inflammatory arthritis PM Giguère, MJ Billard, G Laroche, BK Buckley, RG Timoshchenko, ... Molecular immunology 54 (2), 193-198, 2013 | 32 | 2013 |
