Patrick Giguere
Patrick Giguere
Assistant Professor at University of Ottawa
Verified email at - Homepage
Cited by
Cited by
Structure-based discovery of opioid analgesics with reduced side effects
A Manglik, H Lin, DK Aryal, JD McCorvy, D Dengler, G Corder, A Levit, ...
Nature 537 (7619), 185-190, 2016
PRESTO-Tango as an open-source resource for interrogation of the druggable human GPCRome
WK Kroeze, MF Sassano, XP Huang, K Lansu, JD McCorvy, PM Giguère, ...
Nature structural & molecular biology 22 (5), 362-369, 2015
Molecular control of δ-opioid receptor signalling
G Fenalti, PM Giguere, V Katritch, XP Huang, AA Thompson, V Cherezov, ...
Nature 506 (7487), 191-196, 2014
A new DREADD facilitates the multiplexed chemogenetic interrogation of behavior
E Vardy, JE Robinson, C Li, RHJ Olsen, JF DiBerto, PM Giguere, ...
Neuron 86 (4), 936-946, 2015
Regulators of G-protein signaling and their Gα substrates: promises and challenges in their use as drug discovery targets
AJ Kimple, DE Bosch, PM Giguère, DP Siderovski
Pharmacological reviews 63 (3), 728-749, 2011
The mitochondrial proteins NLRX1 and TUFM form a complex that regulates type I interferon and autophagy
Y Lei, H Wen, Y Yu, DJ Taxman, L Zhang, DG Widman, KV Swanson, ...
Immunity 36 (6), 933-946, 2012
Structural basis for bifunctional peptide recognition at human δ-opioid receptor
G Fenalti, NA Zatsepin, C Betti, P Giguere, GW Han, A Ishchenko, W Liu, ...
Nature structural & molecular biology 22 (3), 265-268, 2015
DREADDs: novel tools for drug discovery and development
HM Lee, PM Giguere, BL Roth
Drug discovery today 19 (4), 469-473, 2014
Nm23-H2 interacts with a G protein-coupled receptor to regulate its endocytosis through an Rac1-dependent mechanism
MD Rochdi, G Laroche, E Dupré, P Giguere, A Lebel, V Watier, E Hamelin, ...
Journal of Biological Chemistry 279 (18), 18981-18989, 2004
The RGS protein inhibitor CCG-4986 is a covalent modifier of the RGS4 Gα-interaction face
AJ Kimple, FS Willard, PM Giguère, CA Johnston, V Mocanu, ...
Biochimica et Biophysica Acta (BBA)-Proteins and Proteomics 1774 (9), 1213-1220, 2007
Oligomerization of the α and β isoforms of the thromboxane A2 receptor: relevance to receptor signaling and endocytosis
G Laroche, MC Lépine, C Thériault, P Giguère, V Giguère, MA Gallant, ...
Cellular signalling 17 (11), 1373-1383, 2005
Peroxiredoxin-4 interacts with and regulates the thromboxane A2 receptor
P Giguère, ME Turcotte, E Hamelin, A Parent, J Brisson, G Laroche, ...
FEBS letters 581 (20), 3863-3868, 2007
Relative ratios of human seasonal coronavirus antibodies predict the efficiency of cross-neutralization of SARS-CoV-2 spike binding to ACE2
Y Galipeau, V Siragam, G Laroche, E Marion, M Greig, M McGuinty, ...
EBioMedicine 74, 2021
Optimization of 2-phenylcyclopropylmethylamines as selective serotonin 2C receptor agonists and their evaluation as potential antipsychotic agents
J Cheng, PM Giguère, OK Onajole, W Lv, A Gaisin, H Gunosewoyo, ...
Journal of medicinal chemistry 58 (4), 1992-2002, 2015
G Protein signaling modulator-3 inhibits the inflammasome activity of NLRP3
PM Giguère, BJ Gall, EAD Ezekwe, G Laroche, BK Buckley, C Kebaier, ...
Journal of Biological Chemistry 289 (48), 33245-33257, 2014
ARF6 activation by Gαq signaling: Gαq forms molecular complexes with ARNO and ARF6
P Giguère, MD Rochdi, G Laroche, É Dupré, MR Whorton, RK Sunahara, ...
Cellular signalling 18 (11), 1988-1994, 2006
A non-canonical function of Gβ as a subunit of E3 ligase in targeting GRK2 ubiquitylation
Z Zha, X Han, MD Smith, Y Liu, PM Giguère, D Kopanja, P Raychaudhuri, ...
Molecular cell 58 (5), 794-803, 2015
High efficiency transient transfection of genes in human umbilical vein endothelial cells by electroporation
T Ear, P Giguère, A Fleury, J Stankova, MD Payet, G Dupuis
Journal of immunological methods 257 (1-2), 41-49, 2001
Design and Discovery of Functionally Selective Serotonin 2C (5-HT2C) Receptor Agonists
J Cheng, JD McCorvy, PM Giguere, H Zhu, T Kenakin, BL Roth, ...
Journal of medicinal chemistry 59 (21), 9866-9880, 2016
G-protein signaling modulator-3, a gene linked to autoimmune diseases, regulates monocyte function and its deficiency protects from inflammatory arthritis
PM Giguère, MJ Billard, G Laroche, BK Buckley, RG Timoshchenko, ...
Molecular immunology 54 (2), 193-198, 2013
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