Karen Blyth
Karen Blyth
CRUK Beatson Institute
Zweryfikowany adres z beatson.gla.ac.uk - Strona główna
Cytowane przez
Cytowane przez
Serine starvation induces stress and p53-dependent metabolic remodelling in cancer cells
ODK Maddocks, CR Berkers, SM Mason, L Zheng, K Blyth, E Gottlieb, ...
Nature 493 (7433), 542-546, 2013
Acetyl-CoA synthetase 2 promotes acetate utilization and maintains cancer cell growth under metabolic stress
ZT Schug, B Peck, DT Jones, Q Zhang, S Grosskurth, IS Alam, ...
Cancer cell 27 (1), 57-71, 2015
The RUNX genes: gain or loss of function in cancer
K Blyth, ER Cameron, JC Neil
Nature Reviews Cancer 5 (5), 376-387, 2005
Modulating the therapeutic response of tumours to dietary serine and glycine starvation
ODK Maddocks, D Athineos, EC Cheung, P Lee, T Zhang, ...
Nature 544 (7650), 372-376, 2017
Limited mitochondrial permeabilization causes DNA damage and genomic instability in the absence of cell death
G Ichim, J Lopez, SU Ahmed, N Muthalagu, E Giampazolias, ME Delgado, ...
Molecular cell 57 (5), 860-872, 2015
Improving the metabolic fidelity of cancer models with a physiological cell culture medium
J Vande Voorde, T Ackermann, N Pfetzer, D Sumpton, G Mackay, G Kalna, ...
Science advances 5 (1), eaau7314, 2019
Pyruvate carboxylation enables growth of SDH-deficient cells by supporting aspartate biosynthesis
S Cardaci, L Zheng, G MacKay, NJF Van den Broek, ED MacKenzie, ...
Nature cell biology 17 (10), 1317-1326, 2015
Fumarate induces redox-dependent senescence by modifying glutathione metabolism
L Zheng, S Cardaci, L Jerby, ED MacKenzie, M Sciacovelli, TI Johnson, ...
Nature communications 6 (1), 6001, 2015
Proviral insertions induce the expression of bone-specific isoforms of PEBP2αA (CBFA1): Evidence for a new myc collaborating oncogene
M Stewart, A Terry, M Hu, M O’hara, K Blyth, E Baxter, E Cameron, ...
Proceedings of the National Academy of Sciences 94 (16), 8646-8651, 1997
Acetate recapturing by nuclear acetyl-CoA synthetase 2 prevents loss of histone acetylation during oxygen and serum limitation
V Bulusu, S Tumanov, E Michalopoulou, NJ van den Broek, G MacKay, ...
Cell reports 18 (3), 647-658, 2017
Mitochondrial permeabilization engages NF-κB-dependent anti-tumour activity under caspase deficiency
E Giampazolias, B Zunino, S Dhayade, F Bock, C Cloix, K Cao, A Roca, ...
Nature cell biology 19 (9), 1116-1129, 2017
In vivo models in breast cancer research: progress, challenges and future directions
I Holen, V Speirs, B Morrissey, K Blyth
Disease models & mechanisms 10 (4), 359-371, 2017
X-SCID transgene leukaemogenicity
AJ Thrasher, HB Gaspar, C Baum, U Modlich, A Schambach, F Candotti, ...
Nature 443 (7109), E5-E6, 2006
Tumor matrix stiffness promotes metastatic cancer cell interaction with the endothelium
SE Reid, EJ Kay, LJ Neilson, AT Henze, J Serneels, EJ McGhee, ...
The EMBO journal 36 (16), 2373-2389, 2017
TIGAR is required for efficient intestinal regeneration and tumorigenesis
EC Cheung, D Athineos, P Lee, RA Ridgway, W Lambie, C Nixon, ...
Developmental cell 25 (5), 463-477, 2013
CRISPR/Cas9-mediated Trp53 and Brca2 knockout to generate improved murine models of ovarian high-grade serous carcinoma
J Walton, J Blagih, D Ennis, E Leung, S Dowson, M Farquharson, ...
Cancer research 76 (20), 6118-6129, 2016
N-WASP coordinates the delivery and F-actin–mediated capture of MT1-MMP at invasive pseudopods
X Yu, T Zech, L McDonald, EG Gonzalez, A Li, I Macpherson, JP Schwarz, ...
Journal of cell biology 199 (3), 527-544, 2012
Dynamic ROS control by TIGAR regulates the initiation and progression of pancreatic cancer
EC Cheung, GM DeNicola, C Nixon, K Blyth, CF Labuschagne, ...
Cancer cell 37 (2), 168-182. e4, 2020
MCL-1 is a prognostic indicator and drug target in breast cancer
KJ Campbell, S Dhayade, N Ferrari, AH Sims, E Johnson, SM Mason, ...
Cell death & disease 9 (2), 19, 2018
Serine synthesis pathway inhibition cooperates with dietary serine and glycine limitation for cancer therapy
M Tajan, M Hennequart, EC Cheung, F Zani, AK Hock, N Legrave, ...
Nature communications 12 (1), 366, 2021
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