Adam Lesner
Adam Lesner
Wydział Chemii, Uniwersytet Gdański
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Cited by
Cited by
Antimicrobial peptides (AMPs) as drug candidates: a patent review (2003–2015)
P Kosikowska, A Lesner
Expert opinion on therapeutic patents 26 (6), 689-702, 2016
Sunflower trypsin inhibitor 1 as a molecular scaffold for drug discovery
A Lesner, A Legowska, M Wysocka, K Rolka
Current pharmaceutical design 17 (38), 4308-4317, 2011
Introduction of non-natural amino acid residues into the substrate-specific P1 position of trypsin inhibitor SFTI-1 yields potent chymotrypsin and cathepsin G inhibitors
A Łęgowska, D Dębowski, A Lesner, M Wysocka, K Rolka
Bioorganic & medicinal chemistry 17 (9), 3302-3307, 2009
Neutrophil proteinase 3 and dipeptidyl peptidase I (cathepsin C) as pharmacological targets in granulomatosis with polyangiitis (Wegener granulomatosis)
B Korkmaz, A Lesner, S Letast, YK Mahdi, ML Jourdan, S Dallet-Choisy, ...
Seminars in immunopathology 35 (4), 411-421, 2013
Therapeutic targeting of cathepsin C: from pathophysiology to treatment
B Korkmaz, GH Caughey, I Chapple, F Gauthier, J Hirschfeld, DE Jenne, ...
Pharmacology & therapeutics 190, 202-236, 2018
Design of selective substrates of proteinase 3 using combinatorial chemistry methods
M Wysocka, A Lesner, K Guzow, L Mackiewicz, A Łęgowska, W Wiczk, ...
Analytical biochemistry 378 (2), 208-215, 2008
Substrate profiling of Zika virus NS 2B‐NS 3 protease
N Gruba, JI Rodriguez Martinez, R Grzywa, M Wysocka, M Skoreński, ...
FEBS letters 590 (20), 3459-3468, 2016
Identification of X-DING-CD4, a new member of human DING protein family that is secreted by HIV-1 resistant CD4+ T cells and has anti-viral activity
A Lesner, R Shilpi, A Ivanova, MA Gawinowicz, J Lesniak, D Nikolov, ...
Biochemical and biophysical research communications 389 (2), 284-289, 2009
Structural and functional analysis of human HtrA3 protease and its subdomains
P Glaza, J Osipiuk, T Wenta, D Zurawa-Janicka, M Jarzab, A Lesner, ...
PloS one 10 (6), e0131142, 2015
Design of serine proteinase inhibitors by combinatorial chemistry using trypsin inhibitor SFTI‐1 as a starting structure
E Zabłotna, A Ja¶kiewicz, A Łęgowska, H Miecznikowska, A Lesner, ...
Journal of Peptide Science: An Official Publication of the European Peptide …, 2007
Neutrophilic cathepsin C is maturated by a multistep proteolytic process and secreted by activated cells during inflammatory lung diseases
Y Hamon, M Legowska, V Hervé, S Dallet-Choisy, S Marchand-Adam, ...
Journal of Biological Chemistry 291 (16), 8486-8499, 2016
Surface plasmon resonance imaging biosensor for cathepsin G based on a potent inhibitor: development and applications
E Gorodkiewicz, M Sieńczyk, E Regulska, R Grzywa, E Pietrusewicz, ...
Analytical biochemistry 423 (2), 218-223, 2012
Trypsin inhibitors from the garden four o’clock (Mirabilis jalapa) and spinach (Spinacia oleracea) seeds: isolation, characterization and chemical synthesis
J Kowalska, K Pszczoła, A Wilimowska-Pelc, I Lorenc-Kubis, E Zuziak, ...
Phytochemistry 68 (11), 1487-1496, 2007
Aggregated neutrophil extracellular traps resolve inflammation by proteolysis of cytokines and chemokines and protection from antiproteases
J Hahn, C Schauer, C Czegley, L Kling, L Petru, B Schmid, D Weidner, ...
The FASEB Journal 33 (1), 1401-1414, 2019
New selective peptidyl di (chlorophenyl) phosphonate esters for visualizing and blocking neutrophil proteinase 3 in human diseases
C Guarino, M Legowska, C Epinette, C Kellenberger, S Dallet-Choisy, ...
Journal of Biological Chemistry 289 (46), 31777-31791, 2014
Cathepsin G activity lowers plasma LDL and reduces atherosclerosis
J Wang, S Sjöberg, TT Tang, K Öörni, W Wu, C Liu, B Secco, V Tia, ...
Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease 1842 (11 …, 2014
Selection of new chromogenic substrates of serine proteinases using combinatorial chemistry methods
M Wysocka, B Kwiatkowska, M Rzadkiewicz, A Lesner, K Rolka
Combinatorial chemistry & high throughput screening 10 (3), 171-180, 2007
Temperature-induced changes of HtrA2 (Omi) protease activity and structure
D Zurawa-Janicka, M Jarzab, A Polit, J Skorko-Glonek, A Lesner, A Gitlin, ...
Cell Stress and Chaperones 18 (1), 35-51, 2013
Substrate specificity and inhibitory study of human airway trypsin-like protease
M Wysocka, B Spichalska, A Lesner, M Jaros, K Brzozowski, A Łęgowska, ...
Bioorganic & medicinal chemistry 18 (15), 5504-5509, 2010
New chromogenic substrates of human neutrophil cathepsin G containing non-natural aromatic amino acid residues in position P1 selected by combinatorial …
M Wysocka, A Łȩgowska, E Bulak, A Ja¶kiewicz, H Miecznikowska, ...
Molecular diversity 11 (2), 93-99, 2007
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