| Antimicrobial peptides (AMPs) as drug candidates: a patent review (2003–2015) P Kosikowska, A Lesner Expert opinion on therapeutic patents 26 (6), 689-702, 2016 | 71 | 2016 |
| Sunflower trypsin inhibitor 1 as a molecular scaffold for drug discovery A Lesner, A Legowska, M Wysocka, K Rolka Current pharmaceutical design 17 (38), 4308-4317, 2011 | 38 | 2011 |
| Introduction of non-natural amino acid residues into the substrate-specific P1 position of trypsin inhibitor SFTI-1 yields potent chymotrypsin and cathepsin G inhibitors A Łęgowska, D Dębowski, A Lesner, M Wysocka, K Rolka Bioorganic & medicinal chemistry 17 (9), 3302-3307, 2009 | 37 | 2009 |
| Neutrophil proteinase 3 and dipeptidyl peptidase I (cathepsin C) as pharmacological targets in granulomatosis with polyangiitis (Wegener granulomatosis) B Korkmaz, A Lesner, S Letast, YK Mahdi, ML Jourdan, S Dallet-Choisy, ... Seminars in immunopathology 35 (4), 411-421, 2013 | 35 | 2013 |
| Design of selective substrates of proteinase 3 using combinatorial chemistry methods M Wysocka, A Lesner, K Guzow, L Mackiewicz, A Łęgowska, W Wiczk, ... Analytical biochemistry 378 (2), 208-215, 2008 | 35 | 2008 |
| Substrate profiling of Zika virus NS 2B‐NS 3 protease N Gruba, JI Rodriguez Martinez, R Grzywa, M Wysocka, M Skoreński, ... FEBS letters 590 (20), 3459-3468, 2016 | 29 | 2016 |
| Structural and functional analysis of human HtrA3 protease and its subdomains P Glaza, J Osipiuk, T Wenta, D Zurawa-Janicka, M Jarzab, A Lesner, ... PloS one 10 (6), e0131142, 2015 | 29 | 2015 |
| Design of serine proteinase inhibitors by combinatorial chemistry using trypsin inhibitor SFTI‐1 as a starting structure E Zabłotna, A Ja¶kiewicz, A Łęgowska, H Miecznikowska, A Lesner, ... Journal of peptide science: an official publication of the European Peptide …, 2007 | 29 | 2007 |
| Surface plasmon resonance imaging biosensor for cathepsin G based on a potent inhibitor: development and applications E Gorodkiewicz, M Sieńczyk, E Regulska, R Grzywa, E Pietrusewicz, ... Analytical biochemistry 423 (2), 218-223, 2012 | 28 | 2012 |
| Identification of X-DING-CD4, a new member of human DING protein family that is secreted by HIV-1 resistant CD4+ T cells and has anti-viral activity A Lesner, R Shilpi, A Ivanova, MA Gawinowicz, J Lesniak, D Nikolov, ... Biochemical and biophysical research communications 389 (2), 284-289, 2009 | 28 | 2009 |
| Temperature-induced changes of HtrA2 (Omi) protease activity and structure D Zurawa-Janicka, M Jarzab, A Polit, J Skorko-Glonek, A Lesner, A Gitlin, ... Cell Stress and Chaperones 18 (1), 35-51, 2013 | 27 | 2013 |
| Trypsin inhibitors from the garden four o’clock (Mirabilis jalapa) and spinach (Spinacia oleracea) seeds: isolation, characterization and chemical synthesis J Kowalska, K Pszczoła, A Wilimowska-Pelc, I Lorenc-Kubis, E Zuziak, ... Phytochemistry 68 (11), 1487-1496, 2007 | 27 | 2007 |
| New selective peptidyl di (chlorophenyl) phosphonate esters for visualizing and blocking neutrophil proteinase 3 in human diseases C Guarino, M Legowska, C Epinette, C Kellenberger, S Dallet-Choisy, ... Journal of Biological Chemistry 289 (46), 31777-31791, 2014 | 26 | 2014 |
| Selection of new chromogenic substrates of serine proteinases using combinatorial chemistry methods M Wysocka, B Kwiatkowska, M Rzadkiewicz, A Lesner, K Rolka Combinatorial chemistry & high throughput screening 10 (3), 171-180, 2007 | 26 | 2007 |
| Neutrophilic cathepsin C is maturated by a multistep proteolytic process and secreted by activated cells during inflammatory lung diseases Y Hamon, M Legowska, V Hervé, S Dallet-Choisy, S Marchand-Adam, ... Journal of Biological Chemistry 291 (16), 8486-8499, 2016 | 25 | 2016 |
| New chromogenic substrates of human neutrophil cathepsin G containing non-natural aromatic amino acid residues in position P1 selected by combinatorial … M Wysocka, A Łȩgowska, E Bulak, A Ja¶kiewicz, H Miecznikowska, ... Molecular diversity 11 (2), 93-99, 2007 | 25 | 2007 |
| Therapeutic targeting of cathepsin C: from pathophysiology to treatment B Korkmaz, GH Caughey, I Chapple, F Gauthier, J Hirschfeld, DE Jenne, ... Pharmacology & therapeutics 190, 202-236, 2018 | 23 | 2018 |
| Cathepsin G activity lowers plasma LDL and reduces atherosclerosis J Wang, S Sjöberg, TT Tang, K Öörni, W Wu, C Liu, B Secco, V Tia, ... Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease 1842 (11 …, 2014 | 23 | 2014 |
| Substrate specificity and inhibitory study of human airway trypsin-like protease M Wysocka, B Spichalska, A Lesner, M Jaros, K Brzozowski, A Łęgowska, ... Bioorganic & medicinal chemistry 18 (15), 5504-5509, 2010 | 23 | 2010 |
| Application of specific cell permeable cathepsin G inhibitors resulted in reduced antigen processing in primary dendritic cells M Reich, A Lesner, A Łęgowska, M Sieńczyk, J Oleksyszyn, BO Boehm, ... Molecular immunology 46 (15), 2994-2999, 2009 | 23 | 2009 |
Magdalena WysockaWydział Chemii Uniwersytet GdańskiVerified email at ug.edu.pl
