Follow
Nicholas M Pearce
Nicholas M Pearce
Assistant Professor, Linköping University
Verified email at liu.se - Homepage
Title
Cited by
Cited by
Year
The CCP4 suite: integrative software for macromolecular crystallography
J Agirre, M Atanasova, H Bagdonas, CB Ballard, A Baslé, ...
Acta Crystallographica Section D: Structural Biology 79 (6), 449-461, 2023
3142023
A multi-crystal method for extracting obscured crystallographic states from conventionally uninterpretable electron density
NM Pearce, T Krojer, AR Bradley, P Collins, RP Nowak, R Talon, ...
Nature communications 8 (1), 15123, 2017
2682017
An expanded allosteric network in PTP1B by multitemperature crystallography, fragment screening, and covalent tethering
DA Keedy, ZB Hill, JT Biel, E Kang, TJ Rettenmaier, J Brandao-Neto, ...
Elife 7, e36307, 2018
1612018
Gentle, fast and effective crystal soaking by acoustic dispensing
PM Collins, JT Ng, R Talon, K Nekrosiute, T Krojer, A Douangamath, ...
Acta Crystallographica Section D: Structural Biology 73 (3), 246-255, 2017
1102017
The XChemExplorer graphical workflow tool for routine or large-scale protein–ligand structure determination
T Krojer, R Talon, N Pearce, P Collins, A Douangamath, J Brandao-Neto, ...
Acta Crystallographica Section D: Structural Biology 73 (3), 267-278, 2017
1092017
Proper modelling of ligand binding requires an ensemble of bound and unbound states
NM Pearce, T Krojer, F Von Delft
Acta Crystallographica Section D: Structural Biology 73 (3), 256-266, 2017
722017
Bicyclic Β‐sheet mimetics that target the transcriptional coactivator Β‐catenin and inhibit Wnt signaling
M Wendt, R Bellavita, A Gerber, NL Efrém, T van Ramshorst, NM Pearce, ...
Angewandte Chemie International Edition 60 (25), 13937-13944, 2021
482021
Insights into enhanced complement activation by structures of properdin and its complex with the C-terminal domain of C3b
RM Van den Bos, NM Pearce, J Granneman, THC Brondijk, P Gros
Frontiers in immunology 10, 2097, 2019
462019
Achieving efficient fragment screening at XChem facility at diamond light source
A Douangamath, A Powell, D Fearon, PM Collins, R Talon, T Krojer, ...
JoVE (Journal of Visualized Experiments), e62414, 2021
412021
Partial-occupancy binders identified by the Pan-Dataset Density Analysis method offer new chemical opportunities and reveal cryptic binding sites
NM Pearce, AR Bradley, T Krojer, BD Marsden, CM Deane, F Von Delft
Structural Dynamics 4 (3), 2017
342017
A method for intuitively extracting macromolecular dynamics from structural disorder
NM Pearce, P Gros
Nature communications 12 (1), 5493, 2021
272021
Implications for tetraspanin-enriched microdomain assembly based on structures of CD9 with EWI-F
W Oosterheert, KT Xenaki, V Neviani, W Pos, S Doulkeridou, ...
Life Science Alliance 3 (11), 2020
272020
Improving sampling of crystallographic disorder in ensemble refinement
N Ploscariu, T Burnley, P Gros, NM Pearce
Acta Crystallographica Section D: Structural Biology 77 (11), 1357-1364, 2021
252021
Mechanistic insights into the C 55-P targeting lipopeptide antibiotics revealed by structure–activity studies and high-resolution crystal structures
TM Wood, MR Zeronian, N Buijs, K Bertheussen, HK Abedian, ...
Chemical Science 13 (10), 2985-2991, 2022
122022
Ten simple rules for surviving an interdisciplinary PhD
S Demharter, N Pearce, K Beattie, I Frost, J Leem, A Martin, ...
PLoS Computational Biology 13 (5), e1005512, 2017
112017
Of problems and opportunities—How to treat and how to not treat crystallographic fragment screening data
MS Weiss, J Wollenhaupt, GJ Correy, JS Fraser, A Heine, G Klebe, ...
Protein Science 31 (9), e4391, 2022
102022
Crystallography Made Crystal Clear: A Guide for Users of Macromolecular Models
AR Pearson, N Pearce, J Wierman
Academic Press, 2022
82022
Covalent bicyclization of protein complexes yields durable quaternary structures
GH Hutchins, S Kiehstaller, P Poc, AH Lewis, J Oh, R Sadighi, NM Pearce, ...
Chem 10 (2), 615-627, 2024
42024
Experiences from developing software for large X-ray crystallography-driven protein-ligand studies
NM Pearce, R Skyner, T Krojer
Frontiers in Molecular Biosciences 9, 861491, 2022
32022
Crystallographic approach to fragment-based hit discovery against Schistosoma mansoni purine nucleoside phosphorylase
M Faheem, N Fonseca Valadares, J Brandăo-Neto, D Bellini, P Collins, ...
Biochemical Journal 478 (19), 3655-3670, 2021
12021
The system can't perform the operation now. Try again later.
Articles 1–20