| The rebel angel: mutant p53 as the driving oncogene in breast cancer D Walerych, M Napoli, L Collavin, G Del Sal Carcinogenesis 33 (11), 2007-2017, 2012 | 375 | 2012 |
| Proteasome machinery is instrumental in a common gain-of-function program of the p53 missense mutants in cancer D Walerych, K Lisek, R Sommaggio, S Piazza, Y Ciani, E Dalla, ... Nature cell biology 18 (8), 897-909, 2016 | 241 | 2016 |
| The diverse members of the mammalian HSP70 machine show distinct chaperone-like activities J Hageman, MAWH van Waarde, A Zylicz, D Walerych, HH Kampinga Biochemical Journal 435 (1), 127-142, 2011 | 216 | 2011 |
| Hsp90 regulates the activity of wild type p53 under physiological and elevated temperatures L Müller, A Schaupp, D Walerych, H Wegele, J Buchner Journal of Biological Chemistry 279 (47), 48846-48854, 2004 | 182 | 2004 |
| Hsp90 chaperones wild-type p53 tumor suppressor protein D Walerych, G Kudla, M Gutkowska, B Wawrzynow, L Muller, FW King, ... Journal of Biological Chemistry 279 (47), 48836-48845, 2004 | 181 | 2004 |
| Mutant p53 tunes the NRF2-dependent antioxidant response to support survival of cancer cells K Lisek, E Campaner, Y Ciani, D Walerych, G Del Sal Oncotarget 9 (29), 20508, 2018 | 101 | 2018 |
| Mutant p53: one, no one, and one hundred thousand D Walerych, K Lisek, G Del Sal Frontiers in oncology 5, 289, 2015 | 100 | 2015 |
| Hsp70 molecular chaperones are required to support p53 tumor suppressor activity under stress conditions D Walerych, MB Olszewski, M Gutkowska, A Helwak, M Zylicz, A Zylicz Oncogene 28 (48), 4284-4294, 2009 | 94 | 2009 |
| Targeting mutant p53 in cancer: a long road to precision therapy F Mantovani, D Walerych, GD Sal The FEBS journal 284 (6), 837-850, 2017 | 83 | 2017 |
| Mutant p53 inhibits miRNA biogenesis by interfering with the microprocessor complex F Garibaldi, E Falcone, D Trisciuoglio, T Colombo, K Lisek, D Walerych, ... Oncogene 35 (29), 3760-3770, 2016 | 54 | 2016 |
| ATP binding to Hsp90 is sufficient for effective chaperoning of p53 protein D Walerych, M Gutkowska, MP Klejman, B Wawrzynow, Z Tracz, M Wiech, ... Journal of biological chemistry 285 (42), 32020-32028, 2010 | 51 | 2010 |
| The new platinum (IV) derivative LA-12 shows stronger inhibitory effect on Hsp90 function compared to cisplatin V Kvardova, R Hrstka, D Walerych, P Muller, E Matoulkova, V Hruskova, ... Molecular cancer 9, 1-9, 2010 | 40 | 2010 |
| Mutant p53–Nrf2 axis regulates the proteasome machinery in cancer K Lisek, D Walerych, G Del Sal Molecular & Cellular Oncology 4 (1), e1217967, 2017 | 19 | 2017 |
| A driver never works alone—interplay networks of mutant p53, MYC, RAS, and other universal oncogenic drivers in human cancer M Grzes, M Oron, Z Staszczak, A Jaiswar, M Nowak-Niezgoda, ... Cancers 12 (6), 1532, 2020 | 17 | 2020 |
| Wild-type p53 oligomerizes more efficiently than p53 hot-spot mutants and overcomes mutant p53 gain-of-function via a “dominant-positive” mechanism D Walerych, M Pruszko, L Zyla, M Wezyk, K Gaweda-Walerych, A Zylicz Oncotarget 9 (62), 32063, 2018 | 15 | 2018 |
| Parkin levels decrease in fibroblasts with progranulin (PGRN) pathogenic variants and in a cellular model of PGRN deficiency K Gaweda-Walerych, D Walerych, M Berdyński, E Buratti, C Zekanowski Frontiers in Molecular Neuroscience 14, 676478, 2021 | 13 | 2021 |
| Cooperation of p53 mutations with other oncogenic alterations in cancer JE Girardini, D Walerych, G Del Sal Mutant p53 and MDM2 in Cancer, 41-70, 2014 | 13 | 2014 |
| Identification of a HLA-A* 0201-restricted immunogenic epitope from the universal tumor antigen DEPDC1 A Tosi, S Dalla Santa, E Cappuzzello, C Marotta, D Walerych, G Del Sal, ... OncoImmunology 6 (8), e1313371, 2017 | 11 | 2017 |
| The molecular network of the proteasome machinery inhibition response is orchestrated by HSP70, revealing vulnerabilities in cancer cells M Oroń, M Grochowski, A Jaiswar, J Legierska, K Jastrzębski, ... Cell Reports 40 (13), 2022 | 8 | 2022 |
| Multi-omics reveals global effects of mutant p53 gain-of-function D Walerych, K Lisek, G Del Sal Cell cycle 15 (22), 3009-3010, 2016 | 4 | 2016 |
Giannino Del SalUniversity of Trieste Department Life Sciences, ICGEB-Area Science Park Trieste, IFOM-Milan,ItalyVerified email at units.it
