Targeting HSP70: the second potentially druggable heat shock protein and molecular chaperone? MV Powers, K Jones, C Barillari, I Westwood, RLM Montfort, P Workman Cell cycle 9 (8), 1542-1550, 2010 | 220 | 2010 |
Arylamine N-acetyltransferases: Structural and functional implications of polymorphisms E Sim, N Lack, CJ Wang, H Long, I Westwood, E Fullam, A Kawamura Toxicology 254 (3), 170-183, 2008 | 155 | 2008 |
Prospective virtual screening with Ultrafast Shape Recognition: the identification of novel inhibitors of arylamine N-acetyltransferases PJ Ballester, I Westwood, N Laurieri, E Sim, WG Richards Journal of The Royal Society Interface 7 (43), 335-342, 2010 | 100 | 2010 |
8-Substituted Pyrido[3,4-d]pyrimidin-4(3H)-one Derivatives As Potent, Cell Permeable, KDM4 (JMJD2) and KDM5 (JARID1) Histone Lysine Demethylase Inhibitors V Bavetsias, RM Lanigan, GF Ruda, B Atrash, MG McLaughlin, A Tumber, ... Journal of medicinal chemistry 59 (4), 1388-1409, 2016 | 99 | 2016 |
Mutations in the PP2A regulatory subunit B family genes PPP2R5B, PPP2R5C and PPP2R5D cause human overgrowth C Loveday, K Tatton-Brown, M Clarke, I Westwood, A Renwick, E Ramsay, ... Human molecular genetics 24 (17), 4775-4779, 2015 | 98 | 2015 |
Selective small molecule inhibitors of the potential breast cancer marker, human arylamine N-acetyltransferase 1, and its murine homologue, mouse arylamine N-acetyltransferase 2 AJ Russell, IM Westwood, MHJ Crawford, J Robinson, A Kawamura, ... Bioorganic & medicinal chemistry 17 (2), 905-918, 2009 | 96 | 2009 |
Molecular cloning, characterisation and ligand-bound structure of an azoreductase from Pseudomonas aeruginosa CJ Wang, C Hagemeier, N Rahman, E Lowe, M Noble, M Coughtrie, ... Journal of molecular biology 373 (5), 1213-1228, 2007 | 91 | 2007 |
Arylamine N-acetyltransferases E Sim, I Westwood, E Fullam Expert opinion on drug metabolism & toxicology 3 (2), 169-184, 2007 | 90 | 2007 |
Structure-Based Design of Orally Bioavailable 1H-Pyrrolo[3,2-c]pyridine Inhibitors of Mitotic Kinase Monopolar Spindle 1 (MPS1) S Naud, IM Westwood, A Faisal, P Sheldrake, V Bavetsias, B Atrash, ... Journal of medicinal chemistry 56 (24), 10045-10065, 2013 | 84 | 2013 |
Expression, purification, characterization and structure of Pseudomonas aeruginosa arylamine N-acetyltransferase IM Westwood, SJ Holton, F Rodrigues-Lima, JM Dupret, S Bhakta, ... Biochemical Journal 385 (2), 605-612, 2005 | 83 | 2005 |
Synthesis and in vitro evaluation of novel small molecule inhibitors of bacterial arylamine N-acetyltransferases (NATs) EW Brooke, SG Davies, AW Mulvaney, M Okada, F Pompeo, E Sim, ... Bioorganic & medicinal chemistry letters 13 (15), 2527-2530, 2003 | 77 | 2003 |
Structure-guided evolution of potent and selective CHK1 inhibitors through scaffold morphing JC Reader, TP Matthews, S Klair, KMJ Cheung, J Scanlon, N Proisy, ... Journal of medicinal chemistry 54 (24), 8328-8342, 2011 | 75 | 2011 |
A novel mechanism for azoreduction A Ryan, N Laurieri, CJ Wang, I Westwood, E Lowe, E Sim Acta Crystallographica Section A: Foundations of Crystallography 66 (a1 …, 2010 | 65 | 2010 |
Structure and mechanism of arylamine N-acetyltransferases IM Westwood, A Kawamura, E Fullam, AJ Russell, SG Davies, E Sim Current topics in medicinal chemistry 6 (15), 1641-1654, 2006 | 65 | 2006 |
Identification of arylamine N-acetyltransferase inhibitors as an approach towards novel anti-tuberculars IM Westwood, S Bhakta, AJ Russell, E Fullam, MC Anderton, A Kawamura, ... Protein & Cell 1 (1), 82-95, 2010 | 63 | 2010 |
Insights into the conformational variability and regulation of human Nek2 kinase I Westwood, DM Cheary, JE Baxter, MW Richards, RLM van Montfort, ... Journal of molecular biology 386 (2), 476-485, 2009 | 63 | 2009 |
Reaction mechanism of azoreductases suggests convergent evolution with quinone oxidoreductases A Ryan, CJ Wang, N Laurieri, I Westwood, E Sim Protein & cell 1, 780-790, 2010 | 61 | 2010 |
Divergence of cofactor recognition across evolution: coenzyme A binding in a prokaryotic arylamine N-acetyltransferase E Fullam, IM Westwood, MC Anderton, ED Lowe, E Sim, MEM Noble Journal of molecular biology 375 (1), 178-191, 2008 | 60 | 2008 |
Mouse N-acetyltransferase type 2, the homologue of human N-acetyltransferase type 1 A Kawamura, I Westwood, L Wakefield, H Long, N Zhang, K Walters, ... Biochemical pharmacology 75 (7), 1550-1560, 2008 | 56 | 2008 |
Arylamine N-acetyltransferases in mycobacteria E Sim, J Sandy, D Evangelopoulos, E Fullam, S Bhakta, I Westwood, ... Current Drug Metabolism 9 (6), 510-519, 2008 | 52 | 2008 |