Hybrid modeling and intensified DoE: an approach to accelerate upstream process characterization B Bayer, G Striedner, M Duerkop Biotechnology journal 15 (9), 2000121, 2020 | 44 | 2020 |
Comparison of modeling methods for DoE‐based holistic upstream process characterization B Bayer, M von Stosch, G Striedner, M Duerkop Biotechnology journal 15 (5), 1900551, 2020 | 38 | 2020 |
Digital twin application for model-based doe to rapidly identify ideal process conditions for space-time yield optimization B Bayer, R Dalmau Diaz, M Melcher, G Striedner, M Duerkop Processes 9 (7), 1109, 2021 | 33 | 2021 |
The shortcomings of accurate rate estimations in cultivation processes and a solution for precise and robust process modeling B Bayer, B Sissolak, M Duerkop, M Von Stosch, G Striedner Bioprocess and biosystems engineering 43, 169-178, 2020 | 25 | 2020 |
Model transferability and reduced experimental burden in cell culture process development facilitated by hybrid modeling and intensified design of experiments B Bayer, M Duerkop, G Striedner, B Sissolak Frontiers in Bioengineering and Biotechnology 9, 740215, 2021 | 17 | 2021 |
Soft sensor based on 2D‐fluorescence and process data enabling real‐time estimation of biomass in Escherichia coli cultivations B Bayer, M von Stosch, M Melcher, M Duerkop, G Striedner Engineering in Life Sciences 20 (1-2), 26-35, 2020 | 17 | 2020 |
Comparison of mechanistic and hybrid modeling approaches for characterization of a CHO cultivation process: Requirements, pitfalls and solution paths B Bayer, M Duerkop, R Pörtner, J Möller Biotechnology journal 18 (1), 2200381, 2023 | 11 | 2023 |
Boost dynamic protocols for producing mammalian biopharmaceuticals with intensified DoE—A practical guide to analyses with OLS and hybrid modeling V Nold, L Junghans, B Bayer, L Bisgen, M Duerkop, R Drerup, B Presser, ... Frontiers in Chemical Engineering 4, 1044245, 2023 | 5 | 2023 |
Fundamental insights in early‐stage inclusion body formation J Kopp, B Bayer, C Slouka, G Striedner, M Dürkop, O Spadiut Microbial Biotechnology 16 (5), 893-900, 2023 | 4 | 2023 |
Proton-transfer-reaction mass spectrometry (PTR-MS) for online monitoring of glucose depletion and cell concentrations in HEK 293 gene therapy processes B Bayer, A Maccani, J Jahn, M Duerkop, E Kapeller, R Pletzenauer, ... Biotechnology Letters 44 (1), 77-88, 2022 | 4 | 2022 |
Irreversible and reversible impact on cellular behavior upon intra-experimental process parameter shifts in a CHO semi-continuous perfusion process M Pappenreiter, B Bayer, M Logarušić, B Sissolak, A Jungbauer Biochemical engineering journal 193, 108876, 2023 | 3 | 2023 |