John C Gensel
Tytuł
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Identification of two distinct macrophage subsets with divergent effects causing either neurotoxicity or regeneration in the injured mouse spinal cord
KA Kigerl, JC Gensel, DP Ankeny, JK Alexander, DJ Donnelly, ...
Journal of Neuroscience 29 (43), 13435-13444, 2009
19082009
Macrophage activation and its role in repair and pathology after spinal cord injury
JC Gensel, B Zhang
Brain research 1619, 1-11, 2015
4372015
Topological data analysis for discovery in preclinical spinal cord injury and traumatic brain injury.
FAR Nielson JL, Paquette J, Liu AW, Guandique CF, Tovar CA, Inoue T, Irvine ...
Nat Commun 14 (6), 8581, 2015
259*2015
Behavioral and histological characterization of unilateral cervical spinal cord contusion injury in rats
JC Gensel, CA Tovar, FPT Hamers, RJ Deibert, MS Beattie, ...
Journal of neurotrauma 23 (1), 36-54, 2006
2482006
Cell death after spinal cord injury is exacerbated by rapid TNFα-induced trafficking of GluR2-lacking AMPARs to the plasma membrane
AR Ferguson, RN Christensen, JC Gensel, BA Miller, F Sun, EC Beattie, ...
Journal of Neuroscience 28 (44), 11391-11400, 2008
2372008
Immune activation promotes depression 1 month after diffuse brain injury: a role for primed microglia
AM Fenn, JC Gensel, Y Huang, PG Popovich, J Lifshitz, JP Godbout
Biological psychiatry 76 (7), 575-584, 2014
2212014
Macrophages promote axon regeneration with concurrent neurotoxicity
JC Gensel, S Nakamura, Z Guan, N van Rooijen, DP Ankeny, ...
Journal of Neuroscience 29 (12), 3956-3968, 2009
2102009
Spinal cord injury scarring and inflammation: therapies targeting glial and inflammatory responses
MB Orr, JC Gensel
Neurotherapeutics 15 (3), 541-553, 2018
1742018
IL-4 signaling drives a unique arginase+/IL-1β+ microglia phenotype and recruits macrophages to the inflammatory CNS: consequences of age-related deficits in IL-4Rα after …
AM Fenn, JCE Hall, JC Gensel, PG Popovich, JP Godbout
Journal of Neuroscience 34 (26), 8904-8917, 2014
1662014
Acute transplantation of glial-restricted precursor cells into spinal cord contusion injuries: survival, differentiation, and effects on lesion environment and axonal regeneration
CE Hill, C Proschel, M Noble, M Mayer-Proschel, JC Gensel, MS Beattie, ...
Experimental neurology 190 (2), 289-310, 2004
1532004
An efficient and reproducible method for quantifying macrophages in different experimental models of central nervous system pathology
DJ Donnelly, JC Gensel, DP Ankeny, N van Rooijen, PG Popovich
Journal of neuroscience methods 181 (1), 36-44, 2009
1352009
Predictive screening of M1 and M2 macrophages reveals the immunomodulatory effectiveness of post spinal cord injury azithromycin treatment
JC Gensel, TJ Kopper, B Zhang, MB Orr, WM Bailey
Scientific reports 7 (1), 1-10, 2017
1012017
Macrophages are necessary for epimorphic regeneration in African spiny mice
J Simkin, TR Gawriluk, JC Gensel, AW Seifert
Elife 6, e24623, 2017
932017
Age decreases macrophage IL-10 expression: Implications for functional recovery and tissue repair in spinal cord injury
B Zhang, WM Bailey, KJ Braun, JC Gensel
Experimental neurology 273, 83-91, 2015
792015
Large animal and primate models of spinal cord injury for the testing of novel therapies
BK Kwon, F Streijger, CE Hill, AJ Anderson, M Bacon, MS Beattie, ...
Experimental neurology 269, 154-168, 2015
792015
Spinal cord injury therapies in humans: an overview of current clinical trials and their potential effects on intrinsic CNS macrophages
JC Gensel, DJ Donnelly, PG Popovich
Expert opinion on therapeutic targets 15 (4), 505-518, 2011
772011
Is neuroinflammation in the injured spinal cord different than in the brain? Examining intrinsic differences between the brain and spinal cord
B Zhang, JC Gensel
Experimental neurology 258, 112-120, 2014
742014
Azithromycin drives alternative macrophage activation and improves recovery and tissue sparing in contusion spinal cord injury
B Zhang, WM Bailey, TJ Kopper, MB Orr, DJ Feola, JC Gensel
Journal of neuroinflammation 12 (1), 218, 2015
672015
Transforming growth factor α transforms astrocytes to a growth-supportive phenotype after spinal cord injury
RE White, M Rao, JC Gensel, DM McTigue, BK Kaspar, LB Jakeman
Journal of Neuroscience 31 (42), 15173-15187, 2011
662011
Age increases reactive oxygen species production in macrophages and potentiates oxidative damage after spinal cord injury
B Zhang, WM Bailey, AL McVicar, JC Gensel
Neurobiology of Aging 47, 157-167, 2016
642016
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