Laura E Edgington-Mitchell
Laura E Edgington-Mitchell
Grimwade Research Fellow, University of Melbourne
Zweryfikowany adres z unimelb.edu.au
TytułCytowane przezRok
Noninvasive optical imaging of apoptosis by caspase-targeted activity-based probes
LE Edgington, AB Berger, G Blum, VE Albrow, MG Paulick, N Lineberry, ...
Nature medicine 15 (8), 967, 2009
2512009
Cathepsin B inhibition limits bone metastasis in breast cancer
NP Withana, G Blum, M Sameni, C Slaney, A Anbalagan, MB Olive, ...
Cancer research 72 (5), 1199-1209, 2012
1522012
Functional imaging of proteases: recent advances in the design and application of substrate-based and activity-based probes
LE Edgington, M Verdoes, M Bogyo
Current opinion in chemical biology 15 (6), 798-805, 2011
1342011
Functional imaging of legumain in cancer using a new quenched activity-based probe
LE Edgington, M Verdoes, A Ortega, NP Withana, J Lee, S Syed, ...
Journal of the American Chemical Society 135 (1), 174-182, 2013
1122013
Comparative assessment of substrates and activity based probes as tools for non-invasive optical imaging of cysteine protease activity
G Blum, RM Weimer, LE Edgington, W Adams, M Bogyo
PLoS One 4 (7), 2009
912009
A nonpeptidic cathepsin S activity-based probe for noninvasive optical imaging of tumor-associated macrophages
M Verdoes, LE Edgington, FA Scheeren, M Leyva, G Blum, K Weiskopf, ...
Chemistry & biology 19 (5), 619-628, 2012
822012
Validation of the proteasome as a therapeutic target in Plasmodium using an epoxyketone inhibitor with parasite-specific toxicity
H Li, EL Ponder, M Verdoes, KH Asbjornsdottir, E Deu, LE Edgington, ...
Chemistry & biology 19 (12), 1535-1545, 2012
522012
An optimized activity-based probe for the study of caspase-6 activation
LE Edgington, BJ Van Raam, M Verdoes, C Wierschem, GS Salvesen, ...
Chemistry & biology 19 (3), 340-352, 2012
462012
Treatment of arthritis by macrophage depletion and immunomodulation: testing an apoptosis‐mediated therapy in a humanized death receptor mouse model
J Li, HC Hsu, PA Yang, Q Wu, H Li, LE Edgington, M Bogyo, RP Kimberly, ...
Arthritis & Rheumatism 64 (4), 1098-1109, 2012
442012
Non-invasive imaging of cysteine cathepsin activity in solid tumors using a 64Cu-labeled activity-based probe
G Ren, G Blum, M Verdoes, H Liu, S Syed, LE Edgington, O Gheysens, ...
PloS one 6 (11), 2011
382011
The apoptosis repressor with a CARD domain (ARC) gene is a direct hypoxia-inducible factor 1 target gene and promotes survival and proliferation of VHL-deficient renal cancer cells
OV Razorenova, L Castellini, R Colavitti, LE Edgington, M Nicolau, ...
Molecular and cellular biology 34 (4), 739-751, 2014
302014
Protease-activated receptor-2 in endosomes signals persistent pain of irritable bowel syndrome
NN Jimenez-Vargas, LA Pattison, P Zhao, TM Lieu, R Latorre, DD Jensen, ...
Proceedings of the National Academy of Sciences 115 (31), E7438-E7447, 2018
252018
PD-1 inhibitory receptor downregulates asparaginyl endopeptidase and maintains Foxp3 transcription factor stability in induced regulatory T cells
C Stathopoulou, A Gangaplara, G Mallett, FA Flomerfelt, LP Liniany, ...
Immunity 49 (2), 247-263. e7, 2018
222018
Myoepithelial cell‐specific expression of stefin A as a suppressor of early breast cancer invasion
HM Duivenvoorden, J Rautela, LE Edgington‐Mitchell, A Spurling, ...
The Journal of pathology 243 (4), 496-509, 2017
192017
Fluorescent diphenylphosphonate-based probes for detection of serine protease activity during inflammation
LE Edgington-Mitchell, N Barlow, L Aurelio, A Samha, M Szabo, ...
Bioorganic & medicinal chemistry letters 27 (2), 254-260, 2017
172017
Cysteine cathepsin activity suppresses osteoclastogenesis of myeloid-derived suppressor cells in breast cancer
LE Edgington-Mitchell, J Rautela, HM Duivenvoorden, KM Jayatilleke, ...
Oncotarget 6 (29), 27008, 2015
172015
Live cell imaging and profiling of cysteine cathepsin activity using a quenched activity-based probe
LE Edgington-Mitchell, M Bogyo, M Verdoes
Activity-Based Proteomics, 145-159, 2017
162017
Inhibition of cathepsin proteases attenuates migration and sensitizes aggressive N-Myc amplified human neuroblastoma cells to doxorubicin
L Gangoda, S Keerthikumar, P Fonseka, LE Edgington, CS Ang, C Ozcitti, ...
Oncotarget 6 (13), 11175, 2015
162015
Ferrous iron-dependent drug delivery enables controlled and selective release of therapeutic agents in vivo
E Deu, IT Chen, EMW Lauterwasser, J Valderramos, H Li, LE Edgington, ...
Proceedings of the National Academy of Sciences 110 (45), 18244-18249, 2013
162013
Probes to monitor activity of the paracaspase MALT1
J Hachmann, LE Edgington-Mitchell, M Poreba, LE Sanman, M Drag, ...
Chemistry & biology 22 (1), 139-147, 2015
152015
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