| Optimization of a Novel Binding Motif to (E)-3-(3,5-Difluoro-4-((1R,3R)-2-(2-fluoro-2-methylpropyl)-3-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)phenyl … C De Savi, RH Bradbury, AA Rabow, RA Norman, C de Almeida, ... Journal of medicinal chemistry 58 (20), 8128-8140, 2015 | 176 | 2015 |
| Progress towards a public chemogenomic set for protein kinases and a call for contributions Plos One, https://doi.org/10.1371/journal.pone.018, 2017 | 149* | 2017 |
| Solid‐phase synthesis of a range of O‐phosphorylated peptides by post‐assembly phosphitylation and oxidation DM Andrews, J Kitchin, PW Seale International Journal of Peptide and Protein Research 38 (5), 469-475, 1991 | 113 | 1991 |
| Optimization of novel acyl pyrrolidine inhibitors of hepatitis C virus RNA-dependent RNA polymerase leading to a development candidate MJ Slater, EM Amphlett, DM Andrews, G Bravi, G Burton, AG Cheasty, ... Journal of medicinal chemistry 50 (5), 897-900, 2007 | 105 | 2007 |
| Proposed roles for DNA polymerases alpha and delta at the replication fork KM Downey, CK Tan, DM Andrews, X Li, AG So Cancer cells 6, 403-410, 1988 | 97 | 1988 |
| The kinase chemogenomic set (KCGS): an open science resource for kinase vulnerability identification CI Wells, H Al-Ali, DM Andrews, CRM Asquith, AD Axtman, I Dikic, ... International journal of molecular sciences 22 (2), 566, 2021 | 78 | 2021 |
| Identification and characterization of dual inhibitors of the USP25/28 deubiquitinating enzyme subfamily JD Wrigley, G Gavory, I Simpson, M Preston, H Plant, J Bradley, ... ACS chemical biology 12 (12), 3113-3125, 2017 | 75 | 2017 |
| Small-molecule androgen receptor downregulators as an approach to treatment of advanced prostate cancer RH Bradbury, NJ Hales, AA Rabow, GE Walker, DG Acton, DM Andrews, ... Bioorganic & medicinal chemistry letters 21 (18), 5442-5445, 2011 | 57 | 2011 |
| Asymmetric sulfoxidation using [(3, 3-Dimethoxycamphoryl) sulfonyl] oxaziridine PCB Page, JP Heer, D Bethell, EW Collington, DM Andrews Tetrahedron: Asymmetry 6 (12), 2911-2914, 1995 | 57 | 1995 |
| Synthesis and influenza virus sialidase inhibitory activity of analogues of 4-guanidino-Neu5Ac2en (zanamivir) modified in the glycerol side-chain DM Andrews, PC Cherry, DC Humber, PS Jones, SP Keeling, PF Martin, ... European journal of medicinal chemistry 34 (7-8), 563-574, 1999 | 54 | 1999 |
| A new system for catalytic asymmetric oxidation of sulfides using a hydrogen peroxide based reagent PCB Page, JP Heer, D Bethell, EW Collington, DM Andrews Tetrahedron Letters 35 (51), 9629-9632, 1994 | 53 | 1994 |
| The discovery of AZD5597, a potent imidazole pyrimidine amide CDK inhibitor suitable for intravenous dosing CD Jones, DM Andrews, AJ Barker, K Blades, P Daunt, S East, C Geh, ... Bioorganic & medicinal chemistry letters 18 (24), 6369-6373, 2008 | 51 | 2008 |
| Design of a biased potent small molecule inhibitor of the bromodomain and PHD finger-containing (BRPF) proteins suitable for cellular and in vivo studies N Igoe, ED Bayle, O Fedorov, C Tallant, P Savitsky, C Rogers, DR Owen, ... Journal of medicinal chemistry 60 (2), 668-680, 2017 | 49 | 2017 |
| Short and versatile route to a key intermediate for lactacystin synthesis PC Bulman Page, AS Hamzah, DC Leach, SM Allin, DM Andrews, ... Organic letters 5 (3), 353-355, 2003 | 48 | 2003 |
| Solid‐phase synthesis of O‐mannosylated peptides: two strategies compared DM Andrews, PW Seale International Journal of Peptide and Protein Research 42 (2), 165-170, 1993 | 47 | 1993 |
| Imidazole piperazines: SAR and development of a potent class of cyclin-dependent kinase inhibitors with a novel binding mode MRV Finlay, DG Acton, DM Andrews, AJ Barker, M Dennis, E Fisher, ... Bioorganic & medicinal chemistry letters 18 (15), 4442-4446, 2008 | 46 | 2008 |
| Protein–ligand crystal structures can guide the design of selective inhibitors of the FGFR tyrosine kinase RA Norman, AK Schott, DM Andrews, J Breed, KM Foote, AP Garner, ... Journal of medicinal chemistry 55 (11), 5003-5012, 2012 | 41 | 2012 |
| Imidazole pyrimidine amides as potent, orally bioavailable cyclin-dependent kinase inhibitors CD Jones, DM Andrews, AJ Barker, K Blades, KF Byth, MRV Finlay, ... Bioorganic & medicinal chemistry letters 18 (24), 6486-6489, 2008 | 39 | 2008 |
| Design of a chemical probe for the bromodomain and plant homeodomain finger-containing (BRPF) family of proteins N Igoe, ED Bayle, C Tallant, O Fedorov, JC Meier, P Savitsky, C Rogers, ... Journal of medicinal chemistry 60 (16), 6998-7011, 2017 | 38 | 2017 |
| Imidazoles: SAR and development of a potent class of cyclin-dependent kinase inhibitors M Anderson, DM Andrews, AJ Barker, CA Brassington, J Breed, KF Byth, ... Bioorganic & medicinal chemistry letters 18 (20), 5487-5492, 2008 | 36 | 2008 |
