| Novel butanehydrazide derivatives of purine-2, 6-dione as dual PDE4/7 inhibitors with potential anti-inflammatory activity: design, synthesis and biological evaluation G Chłoń-Rzepa, A Jankowska, M Ślusarczyk, A Świerczek, K Pociecha, ... European journal of medicinal chemistry 146, 381-394, 2018 | 44 | 2018 |
| Antidepressant-and anxiolytic-like activity of 7-phenylpiperazinylalkyl-1, 3-dimethyl-purine-2, 6-dione derivatives with diversified 5-HT1A receptor functional profile A Partyka, G Chłoń-Rzepa, A Wasik, M Jastrzębska-Więsek, A Bucki, ... Bioorganic & medicinal chemistry 23 (1), 212-221, 2015 | 38 | 2015 |
| A novel, pan-PDE inhibitor exerts anti-fibrotic effects in human lung fibroblasts via inhibition of TGF-β signaling and activation of cAMP/PKA signaling K Wójcik-Pszczoła, G Chłoń-Rzepa, A Jankowska, M Ślusarczyk, ... International journal of molecular sciences 21 (11), 4008, 2020 | 34 | 2020 |
| Novel amide derivatives of 1, 3-dimethyl-2, 6-dioxopurin-7-yl-alkylcarboxylic acids as multifunctional TRPA1 antagonists and PDE4/7 inhibitors: a new approach for the treatment … G Chłoń-Rzepa, M Ślusarczyk, A Jankowska, A Gawalska, A Bucki, ... European Journal of Medicinal Chemistry 158, 517-533, 2018 | 32 | 2018 |
| Advances in discovery of PDE10A inhibitors for CNS-related disorders. Part 1: overview of the chemical and biological research A Jankowska, A Świerczek, E Wyska, A Gawalska, A Bucki, M Pawłowski, ... Current Drug Targets 20 (1), 122-143, 2019 | 28 | 2019 |
| 7-Arylpiperazinylalkyl and 7-tetrahydroisoquinolinylalkyl derivatives of 8-alkoxy-purine-2, 6-dione and some of their purine-2, 6, 8-trione analogs as 5-HT1A, 5-HT2A, and 5-HT7 … G Chłoń-Rzepa, P Żmudzki, P Zajdel, AJ Bojarski, B Duszyńska, ... Bioorganic & medicinal chemistry 15 (15), 5239-5250, 2007 | 26 | 2007 |
| Novel anilide and benzylamide derivatives of arylpiperazinylalkanoic acids as 5-HT1A/5-HT7 receptor antagonists and phosphodiesterase 4/7 inhibitors with procognitive and … A Jankowska, G Satała, M Kołaczkowski, A Bucki, M Głuch-Lutwin, ... European Journal of Medicinal Chemistry 201, 112437, 2020 | 20 | 2020 |
| Preliminary study on application of impregnated synthetic peptide TLC stationary phases for the pre‐screening of 5‐HT1A ligands PŁ Zajdel, AJ Bojarski, H Byrtus, G ChŁoń‐Rzepa, J Obniska, P Chevallet, ... Biomedical Chromatography 17 (5), 312-317, 2003 | 19 | 2003 |
| New imidazopyridines with phosphodiesterase 4 and 7 inhibitory activity and their efficacy in animal models of inflammatory and autoimmune diseases V Ručilová, A Świerczek, D Vanda, P Funk, B Lemrová, A Gawalska, ... European Journal of Medicinal Chemistry 209, 112854, 2021 | 18 | 2021 |
| Analgesic activity of new 8-methoxy-1, 3-dimethyl-2, 6-dioxo-purin-7-yl derivatives with carboxylic, ester or amide moieties M Zygmunt, G Chłoń-Rzepa, J Sapa, M Pawłowski Pharmacological Reports 67, 9-16, 2015 | 18 | 2015 |
| Analgesic and anti-inflammatory activity of 7-substituted purine-2, 6-diones M Zygmunt, G Chłoń-Rzepa, J Sapa Pharmacological Reports 66, 996-1002, 2014 | 17 | 2014 |
| Arylpiperazinylalkyl derivatives of 8-amino-1, 3-dimethylpurine-2, 6-dione as novel multitarget 5-HT/D receptor agents with potential antipsychotic activity G Chłoń-Rzepa, A Bucki, M Kołaczkowski, A Partyka, ... Journal of Enzyme Inhibition and Medicinal Chemistry 31 (6), 1048-1062, 2016 | 16 | 2016 |
| Novel phosphodiesterases inhibitors from the group of purine-2, 6-dione derivatives as potent modulators of airway smooth muscle cell remodelling K Wójcik-Pszczoła, G Chłoń-Rzepa, A Jankowska, E Ellen, A Świerczek, ... European Journal of Pharmacology 865, 172779, 2019 | 15 | 2019 |
| Structure–5‐HT Receptor Affinity Relationship in a New Group of 7‐Arylpiperazynylalkyl and 7‐Tetrahydroisoquinolinylalkyl Derivatives of 8‐Amino‐1, 3‐dimethyl‐1H‐purine‐2, 6 … P Żmudzki, G Chłoń‐Rzepa, AJ Bojarski, M Zygmunt, G Kazek, B Mordyl, ... Archiv der Pharmazie 348 (4), 229-241, 2015 | 15 | 2015 |
| 7-3-Chlorophenypiperazinylalkyl derivatives of 8-alkoxy-purine-2, 6-dione as a serotonin receptor ligands with potential antidepressant activity M Zygmunt, J Sapa, G Chłoń-Rzepa, A Zagórska, A Siwek, M Pawłowski, ... Pharmacological Reports 66 (3), 505-510, 2014 | 15 | 2014 |
| New 8-aminoalkyl derivatives of purine-2, 6-dione with arylalkyl, allyl or propynyl substituents in position 7, their 5-HT1A, 5-HT2A, and 5-HT7 receptor affinity and … G Chłoń-Rzepa, P Żmudzki, G Satała, B Duszyńska, A Partyka, D Wróbel, ... Pharmacological Reports 65 (1), 15-29, 2013 | 15 | 2013 |
| Comparative assessment of the new PDE7 inhibitor–GRMS-55 and lisofylline in animal models of immune-related disorders: a PK/PD modeling approach A Świerczek, K Pociecha, M Ślusarczyk, G Chłoń-Rzepa, S Baś, ... Pharmaceutical Research 37, 1-21, 2020 | 14 | 2020 |
| Advances in the discovery of PDE10A inhibitors for CNS-related disorders. Part 2: Focus on schizophrenia A Świerczek, A Jankowska, G Chłoń-Rzepa, M Pawłowski, E Wyska Current Drug Targets 20 (16), 1652-1669, 2019 | 14 | 2019 |
| multifunctional ligands with glycogen synthase kinase 3 inhibitory activity as a new direction in drug research for Alzheimer’s disease A Jankowska, G Sataa, AJ Bojarski, M Pawowski, GŻ Choń-Rzepa Current Medicinal Chemistry 28 (9), 1731-1745, 2021 | 13 | 2021 |
| In vitro biotransformation, safety, and chemopreventive action of novel 8-methoxy-purine-2, 6-dione derivatives MA Marć, E Domínguez-Álvarez, K Słoczyńska, P Żmudzki, ... Applied biochemistry and biotechnology 184, 124-139, 2018 | 13 | 2018 |
