| Remodeling of saccular cerebral artery aneurysm wall is associated with rupture: histological analysis of 24 unruptured and 42 ruptured cases J Frösen, A Piippo, A Paetau, M Kangasniemi, M Niemelä, ... Stroke 35 (10), 2287-2293, 2004 | 803 | 2004 |
| Saccular intracranial aneurysm: pathology and mechanisms J Frösen, R Tulamo, A Paetau, E Laaksamo, M Korja, A Laakso, ... Acta neuropathologica 123, 773-786, 2012 | 511 | 2012 |
| Somatic Activating KRAS Mutations in Arteriovenous Malformations of the Brain SI Nikolaev, S Vetiska, X Bonilla, E Boudreau, S Jauhiainen, ... New England Journal of Medicine 378 (3), 250-261, 2018 | 390 | 2018 |
| Inflammatory changes in the aneurysm wall: a review R Tulamo, J Frösen, J Hernesniemi, M Niemelä Journal of neurointerventional surgery 10 (Suppl 1), i58-i67, 2018 | 282 | 2018 |
| Flow-induced, inflammation-mediated arterial wall remodeling in the formation and progression of intracranial aneurysms J Frösen, J Cebral, AM Robertson, T Aoki Neurosurgical focus 47 (1), E21, 2019 | 212 | 2019 |
| Irregular shape of intracranial aneurysm indicates rupture risk irrespective of size in a population-based cohort AE Lindgren, T Koivisto, J Björkman, M von und zu Fraunberg, K Helin, ... Stroke 47 (5), 1219-1226, 2016 | 202 | 2016 |
| Complement activation associates with saccular cerebral artery aneurysm wall degeneration and rupture R Tulamo, J Frösen, S Junnikkala, A Paetau, J Pitkäniemi, ... Neurosurgery 59 (5), 1069-1077, 2006 | 184 | 2006 |
| Prostaglandin E2–EP2–NF-κB signaling in macrophages as a potential therapeutic target for intracranial aneurysms T Aoki, J Frȍsen, M Fukuda, K Bando, G Shioi, K Tsuji, E Ollikainen, ... Science signaling 10 (465), eaah6037, 2017 | 166 | 2017 |
| Flow conditions in the intracranial aneurysm lumen are associated with inflammation and degenerative changes of the aneurysm wall J Cebral, E Ollikainen, BJ Chung, F Mut, V Sippola, BR Jahromi, ... American Journal of Neuroradiology 38 (1), 119-126, 2017 | 164 | 2017 |
| Familial intracranial aneurysms: an analysis of 346 multiplex Finnish families S Wills, A Ronkainen, M van der Voet, H Kuivaniemi, K Helin, E Leinonen, ... Stroke 34 (6), 1370-1374, 2003 | 142 | 2003 |
| Upregulated signaling pathways in ruptured human saccular intracranial aneurysm wall: an emerging regulative role of Toll-like receptor signaling and nuclear factor-κB, hypoxia … MI Kurki, SK Häkkinen, J Frösen, R Tulamo, M von Und Zu Fraunberg, ... Neurosurgery 68 (6), 1667-1676, 2011 | 141 | 2011 |
| Smooth muscle cells and the formation, degeneration, and rupture of saccular intracranial aneurysm wall—a review of current pathophysiological knowledge J Frösen Translational stroke research 5 (3), 347-356, 2014 | 136 | 2014 |
| Some collected principles of microneurosurgery: simple and fast, while preserving normal anatomy: a review J Hernesniemi, M Niemelä, A Karatas, L Kivipelto, K Ishii, J Rinne, ... Surgical neurology 64 (3), 195-200, 2005 | 125 | 2005 |
| Growth factor receptor expression and remodeling of saccular cerebral artery aneurysm walls: implications for biological therapy preventing rupture J Frösen, A Piippo, A Paetau, M Kangasniemi, M Niemelä, J Hernesniemi, ... Neurosurgery 58 (3), 534-541, 2006 | 119 | 2006 |
| Saccular intracranial aneurysm disease: distribution of site, size, and age suggests different etiologies for aneurysm formation and rupture in 316 familial and 1454 sporadic … T Huttunen, M von und zu Fraunberg, J Frösen, M Lehecka, G Tromp, ... Neurosurgery 66 (4), 631-638, 2010 | 117 | 2010 |
| Selective tyrosine kinase inhibitor for the platelet-derived growth factor receptor in vitro inhibits smooth muscle cell proliferation after reinjury of arterial intima in vivo M Myllärniemi, J Frösen, LG Calderón Ramirez, E Buchdunger, ... Cardiovascular drugs and therapy 13, 159-168, 1999 | 95 | 1999 |
| Loss of mural cells leads to wall degeneration, aneurysm growth, and eventual rupture in a rat aneurysm model S Marbacher, J Marjamaa, K Bradacova, M Von Gunten, P Honkanen, ... Stroke 45 (1), 248-254, 2014 | 94 | 2014 |
| Lipid accumulation, lipid oxidation, and low plasma levels of acquired antibodies against oxidized lipids associate with degeneration and rupture of the intracranial aneurysm wall J Frösen, R Tulamo, T Heikura, S Sammalkorpi, M Niemelä, ... Acta neuropathologica communications 1, 1-13, 2013 | 88 | 2013 |
| Local hemodynamic conditions associated with focal changes in the intracranial aneurysm wall JR Cebral, F Detmer, BJ Chung, J Choque-Velasquez, B Rezai, H Lehto, ... American Journal of Neuroradiology 40 (3), 510-516, 2019 | 86 | 2019 |
| Complement system becomes activated by the classical pathway in intracranial aneurysm walls R Tulamo, J Frösen, S Junnikkala, A Paetau, M Kangasniemi, J Peláez, ... Laboratory Investigation 90 (2), 168-179, 2010 | 75 | 2010 |
