| An orally bioavailable chemical probe of the lysine methyltransferases EZH2 and EZH1 KD Konze, A Ma, F Li, D Barsyte-Lovejoy, T Parton, CJ MacNevin, F Liu, ... ACS chemical biology 8 (6), 1324-1334, 2013 | 480 | 2013 |
| Discovery of a chemical probe for the L3MBTL3 methyllysine reader domain LI James, D Barsyte-Lovejoy, N Zhong, L Krichevsky, VK Korboukh, ... Nature chemical biology 9 (3), 184-191, 2013 | 188 | 2013 |
| Small-molecule ligands of methyl-lysine binding proteins JM Herold, TJ Wigle, JL Norris, R Lam, VK Korboukh, C Gao, ... Journal of medicinal chemistry 54 (7), 2504-2511, 2011 | 136 | 2011 |
| Exploiting an allosteric binding site of PRMT3 yields potent and selective inhibitors F Liu, F Li, A Ma, E Dobrovetsky, A Dong, C Gao, I Korboukh, J Liu, D Smil, ... Journal of medicinal chemistry 56 (5), 2110-2124, 2013 | 76 | 2013 |
| Suppl 1: Targets in Epigenetics: Inhibiting the Methyl Writers of the Histone Code JM Yost, I Korboukh, F Liu, C Gao, J Jin Current chemical genomics 5, 72, 2011 | 76 | 2011 |
| Accounting for ligand conformational restriction in calculations of protein-ligand binding affinities C Gao, MS Park, HA Stern Biophysical journal 98 (5), 901-910, 2010 | 63 | 2010 |
| Predicting the conformational variability of Abl tyrosine kinase using molecular dynamics simulations and Markov state models Y Meng, C Gao, DK Clawson, S Atwell, M Russell, M Vieth, B Roux Journal of chemical theory and computation 14 (5), 2721-2732, 2018 | 52 | 2018 |
| Estimating binding affinities by docking/scoring methods using variable protonation states MS Park, C Gao, HA Stern Proteins: Structure, Function, and Bioinformatics 79 (1), 304-314, 2011 | 52 | 2011 |
| Structure–activity relationships of methyl-lysine reader antagonists JM Herold, LI James, VK Korboukh, C Gao, KE Coil, DJ Bua, JL Norris, ... MedChemComm 3 (1), 45-51, 2012 | 44 | 2012 |
| Suppl 1: Drug Discovery Toward Antagonists of Methyl-Lysine Binding Proteins JM Herold, LA Ingerman, C Gao, SV Frye Current chemical genomics 5, 51, 2011 | 42 | 2011 |
| Biophysical probes reveal a “compromise” nature of the methyl-lysine binding pocket in L3MBTL1 C Gao, JM Herold, D Kireev, T Wigle, JL Norris, S Frye Journal of the American Chemical Society 133 (14), 5357-5362, 2011 | 39 | 2011 |
| What general conclusions can we draw from kinase profiling data sets? JJ Sutherland, C Gao, S Cahya, M Vieth Biochimica et Biophysica Acta (BBA)-Proteins and Proteomics 1834 (7), 1425-1433, 2013 | 34 | 2013 |
| Toward atomistic modeling of irreversible covalent inhibitor binding kinetics HS Yu, C Gao, D Lupyan, Y Wu, T Kimura, C Wu, L Jacobson, E Harder, ... Journal of Chemical Information and Modeling 59 (9), 3955-3967, 2019 | 29 | 2019 |
| Low-temperature SOFCs using biomass-produced gases as fuels Y Yin, W Zhu, C Xia, C Gao, G Meng Journal of applied electrochemistry 34, 1287-1291, 2004 | 19 | 2004 |
| Scoring function accuracy for membrane protein structure prediction C Gao, HA Stern Proteins: Structure, Function, and Bioinformatics 68 (1), 67-75, 2007 | 18 | 2007 |
| Knowledge-based strategy to improve ligand pose prediction accuracy for lead optimization C Gao, N Thorsteinson, I Watson, J Wang, M Vieth Journal of Chemical Information and Modeling 55 (7), 1460-1468, 2015 | 16 | 2015 |
| Are induced fit protein conformational changes caused by ligand‐binding predictable? A molecular dynamics investigation C Gao, J Desaphy, M Vieth Journal of computational chemistry 38 (15), 1229-1237, 2017 | 13 | 2017 |
| New organic semiconductors for thin-film transistors: Synthesis, characterization, and performance of 4H-indeno [1, 2-b] thiophene derivatives C Zhao, X Chen, C Gao, MK Ng, H Ding, K Park, Y Gao Synthetic metals 159 (11), 995-1001, 2009 | 12 | 2009 |
| Selectivity data: assessment, predictions, concordance, and implications C Gao, S Cahya, CA Nicolaou, J Wang, IA Watson, DJ Cummins, ... Journal of Medicinal Chemistry 56 (17), 6991-7002, 2013 | 11 | 2013 |
| Assessment of free energy predictors for ligand binding to a methyllysine histone code reader C Gao, JM Herold, D Kireev Journal of Computational Chemistry 33 (6), 659-665, 2012 | 8 | 2012 |
Martin HeroldAssociate Director, Medicinal ChemistryVerified email at treeline.bio
