Jian Jin
Jian Jin
Professor, Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai
Verified email at
Cited by
Cited by
Dynamic reprogramming of the kinome in response to targeted MEK inhibition in triple-negative breast cancer
JS Duncan, MC Whittle, K Nakamura, AN Abell, AA Midland, ...
Cell 149 (2), 307-321, 2012
The promise and peril of chemical probes
CH Arrowsmith, JE Audia, C Austin, J Baell, J Bennett, J Blagg, C Bountra, ...
Nature chemical biology 11 (8), 536-541, 2015
A chemical probe selectively inhibits G9a and GLP methyltransferase activity in cells
M Vedadi, D Barsyte-Lovejoy, F Liu, S Rival-Gervier, A Allali-Hassani, ...
Nature chemical biology 7 (8), 566-574, 2011
An orally bioavailable chemical probe of the lysine methyltransferases EZH2 and EZH1
KD Konze, A Ma, F Li, D Barsyte-Lovejoy, T Parton, CJ MacNevin, F Liu, ...
ACS chemical biology 8 (6), 1324-1334, 2013
Topoisomerase inhibitors unsilence the dormant allele of Ube3a in neurons
HS Huang, JA Allen, AM Mabb, IF King, J Miriyala, B Taylor-Blake, ...
Nature 481 (7380), 185-189, 2012
Discovery of β-arrestin–biased dopamine D2 ligands for probing signal transduction pathways essential for antipsychotic efficacy
JA Allen, JM Yost, V Setola, X Chen, MF Sassano, M Chen, S Peterson, ...
Proceedings of the National Academy of Sciences 108 (45), 18488-18493, 2011
Inhibition of lapatinib-induced kinome reprogramming in ERBB2-positive breast cancer by targeting BET family bromodomains
TJ Stuhlmiller, SM Miller, JS Zawistowski, K Nakamura, AS Beltran, ...
Cell reports 11 (3), 390-404, 2015
Inhibitors of protein methyltransferases and demethylases
HU Kaniskan, ML Martini, J Jin
Chemical reviews 118 (3), 989-1068, 2018
Discovery of an in vivo chemical probe of the lysine methyltransferases G9a and GLP
F Liu, D Barsyte-Lovejoy, F Li, Y Xiong, V Korboukh, XP Huang, ...
Journal of medicinal chemistry 56 (21), 8931-8942, 2013
In silico design of novel probes for the atypical opioid receptor MRGPRX2
K Lansu, J Karpiak, J Liu, XP Huang, JD McCorvy, WK Kroeze, T Che, ...
Nature chemical biology 13 (5), 529-536, 2017
Advancing targeted protein degradation for cancer therapy
B Dale, M Cheng, KS Park, HÜ Kaniskan, Y Xiong, J Jin
Nature Reviews Cancer 21 (10), 638-654, 2021
Structure and inhibition of microbiome β-glucuronidases essential to the alleviation of cancer drug toxicity
BD Wallace, AB Roberts, RM Pollet, JD Ingle, KA Biernat, SJ Pellock, ...
Chemistry & biology 22 (9), 1238-1249, 2015
First Chelated Chiral N-Heterocyclic Bis-Carbene Complexes
DS Clyne, J Jin, E Genest, JC Gallucci, TV RajanBabu
Organic Letters 2 (8), 1125-1128, 2000
Allosteric ligands for the pharmacologically dark receptors GPR68 and GPR65
XP Huang, J Karpiak, WK Kroeze, H Zhu, X Chen, SS Moy, KA Saddoris, ...
Nature 527 (7579), 477-483, 2015
Discovery of a 2, 4-diamino-7-aminoalkoxyquinazoline as a potent and selective inhibitor of histone lysine methyltransferase G9a
F Liu, X Chen, A Allali-Hassani, AM Quinn, GA Wasney, A Dong, ...
Journal of medicinal chemistry 52 (24), 7950-7953, 2009
Selective inhibition of EZH2 and EZH1 enzymatic activity by a small molecule suppresses MLL-rearranged leukemia
B Xu, DM On, A Ma, T Parton, KD Konze, SG Pattenden, DF Allison, L Cai, ...
Blood, The Journal of the American Society of Hematology 125 (2), 346-357, 2015
A potent, selective, and cell-active inhibitor of human type I protein arginine methyltransferases
MS Eram, Y Shen, MM Szewczyk, H Wu, G Senisterra, F Li, KV Butler, ...
ACS chemical biology 11 (3), 772-781, 2016
Light-induced control of protein destruction by opto-PROTAC
J Liu, H Chen, L Ma, Z He, D Wang, Y Liu, Q Lin, T Zhang, N Gray, ...
Science advances 6 (8), eaay5154, 2020
Protein lysine methyltransferase G9a inhibitors: design, synthesis, and structure activity relationships of 2, 4-diamino-7-aminoalkoxy-quinazolines.
F Liu, X Chen, A Allali-Hassani, AM Quinn, TJ Wigle, GA Wasney, A Dong, ...
Journal of medicinal chemistry 53 (15), 5844-5857, 2010
Mitigation of hematologic radiation toxicity in mice through pharmacological quiescence induced by CDK4/6 inhibition
SM Johnson, CD Torrice, JF Bell, KB Monahan, Q Jiang, Y Wang, ...
The Journal of clinical investigation 120 (7), 2528-2536, 2010
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